Latest Research
Academician Jianzhong Shen’s team has published “Adaptive evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae in the urinary tract of a single patient” in PNAS.
The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) is a growing concern due to its high mortality and limited treatme...
Academician Jianzhong Shen’s team has published “VirBR, a transcription regulator, promotes IncX3 plasmid transmission, and persistence of blaNDM-5 in zoonotic bacteria” in Nature Communications.
IncX3 plasmids carrying the New Delhi metallo-β-lactamase-encoding gene, blaNDM-5, are rapidly spreading globally in both humans and animals. Given th...
Professor Hanchun Yang’s team has published “Disruption of pulmonary microvascular endothelial barrier by dysregulated claudin-8 and claudin-4: uncovered mechanisms in porcine reproductive and respiratory syndrome virus infection” in Cellular and Molecular Life Sciences.
The pulmonary endothelium is a dynamic and metabolically active monolayer of endothelial cells. Dysfunction of the pulmonary endothelial barrier plays...
Professor Yaoxing Chen’s team has published “Allosteric strand displacement isothermal amplification for the visual detection of Toxoplasma gondii in 30 minutes” in Biosensors and Bioelectronics.
Early detection of Toxoplasma gondii (T. gondii) is critical due to a lack of effective treatment for toxoplasmosis.This study established a simple, c...
Professor Hanchun Yang’s team has published “Senecavirus a induces mitophagy to promote self-replication through direct interaction of 2C protein with K27-linked ubiquitinated TUFM catalyzed by RNF185” in Autophagy.
Senecavirus A (SVA) is a newly emerging picornavirus associated with swine vesicular lesions and neonatal mortality, threatening the global pig indust...
Professor Hanchun Yang’s team has published “Riding apoptotic bodies for cell-cell transmission by African swine fever virus” in PNAS.
African swine fever virus (ASFV), a devastating pathogen to the worldwide swine industry, mainly targets macrophage/monocyte lineage, but how the viru...
Associate Professor Tianlong Liu’s team has published “Vital role of autophagy flux inhibition of placental trophoblast cells in pregnancy disorders induced by HEV infection” in Emerging Microbes & Infections.
Hepatitis E virus (HEV) has become one of the important pathogens that threaten the global public health. Type 3 and 4 HEV are zoonotic, which can spr...
Professor Xin Li’s team has published “Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing” in PLoS Pathogens.
RNA viruses cause numerous infectious diseases in humans and animals. The crosstalk between RNA viruses and the innate DNA sensing pathways attracts i...
Professor Jinhua Liu’s team has published “Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets” in Cell.
H3N8 avian influenza viruses (AIVs) in China caused two confirmed human infections in 2022, followed by a fatal case reported in 2023. H3N8 viruses ar...
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