Latest Research
Professor Chen Peng’s team has published “A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability” in PLOS Pathogens.
Poxviruses are large DNA viruses with an arsenal of immune-modulatory genes, many of which remain uncharacterized. Proteins with ankyrin repeats are d...
Academician Jianzhong Shen’s team has published “VirBR counter-silences HppX3 to promote conjugation of blaNDM-IncX3 plasmids” in Nucleic Acids Research.
New Delhi metallo-β-lactamases (NDM), encoded by the blaNDM gene, mediate carbapenem resistance, posing serious threats to public health due to their ...
Professor Xiangmei Zhou’s team has published “Mycobacterium bovis Mb3523c protein regulates host ferroptosis via chaperone-mediated autophagy” in Autophagy.
The occurrence of necrosis during Mycobacterium bovis (M. bovis) infection is regarded as harmful to the host because it promotes the spread of M. bov...
Academician Jianzhong Shen’s team has published “Adipose tissue targeted sequential delivery system regulating glycolipid metabolism for systemic obesity and its comorbidities” in Nano Today.
Obesity has emerged as a chronic, relapsing, progressive disease globally. Available methods including pharmacotherapy, surgery, and limotherapy, may ...
Academician Jianzhong Shen’s team has published “Development of Recombinant High-Density Lipoprotein Platform with Innate Adipose Tissue-Targeting Abilities for Regional Fat Reduction” in ACS Nano.
As an escalating public health issue, obesity and overweight conditions are predispositions to various diseases and are exacerbated by concurrent chro...
Academician Jianzhong Shen’s team has published “Adaptive evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae in the urinary tract of a single patient” in PNAS.
The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) is a growing concern due to its high mortality and limited treatme...
Academician Jianzhong Shen’s team has published “VirBR, a transcription regulator, promotes IncX3 plasmid transmission, and persistence of blaNDM-5 in zoonotic bacteria” in Nature Communications.
IncX3 plasmids carrying the New Delhi metallo-β-lactamase-encoding gene, blaNDM-5, are rapidly spreading globally in both humans and animals. Given th...
Professor Hanchun Yang’s team has published “Disruption of pulmonary microvascular endothelial barrier by dysregulated claudin-8 and claudin-4: uncovered mechanisms in porcine reproductive and respiratory syndrome virus infection” in Cellular and Molecular Life Sciences.
The pulmonary endothelium is a dynamic and metabolically active monolayer of endothelial cells. Dysfunction of the pulmonary endothelial barrier plays...
Professor Yaoxing Chen’s team has published “Allosteric strand displacement isothermal amplification for the visual detection of Toxoplasma gondii in 30 minutes” in Biosensors and Bioelectronics.
Early detection of Toxoplasma gondii (T. gondii) is critical due to a lack of effective treatment for toxoplasmosis.This study established a simple, c...
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