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Preventive Veterinary Medicine

Kang Ning, PhD

Professor of Virology

kning@cau.edu.cn

010-62733348

Education

  • 09/2008–07/2012   B.S. in Animal Science, Shandong Agricultural University, China

  • 09/2013–07/2018   Ph.D. in Preventative Veterinary Medicine, China Agricultural University, China


Training and Professional Experience

  • 07/2018–05/2024, Postdoctoral Fellow, Department of Microbiology, Molecular Genetics & Immunology, The University of Kansas Medical Center

  • 2024-now, Professor, China Agricultural University College of Veterinary Medicine


Research Interests

Dr. Ning's current researches have been focusing on 1) Etiology, molecular epidemiology, and pathogenesis of waterfowl diseases. 2) Replication, pathogenesis and host immune responses of viruses in waterfowl (e.g. TMUV, DHV, GPV and DRV). 3) Fundamental investigation of parvoviruses, including infection, viral-host interaction and pathogenicity mechanism. These researches aim to promote animal and human health.


Reviewer for 

  • Avian Pathology

  • Veterinary Sciences

  • Frontiers in Immunology

  • Frontiers in Microbiology

  • International Journal of Molecular Sciences

  • Viruses

  • Animals

  • Cells


Selected Publications

1. Ning, K., Zhao, J., Feng, Z., Park, S.Y., McFarlin, S., Cheng, F., Yan, Z., Wang, J., Qiu, J. (2024). N6-methyladenosine modification of a parvovirus-encoded small noncoding RNA facilitates viral DNA replication through recruiting Y-family DNA polymerases. Proc Natl Acad Sci U S A (PNAS). 2024, Jun 18;121(25):e2320782121. 

2. Ning, K., Zou, W., Xu, P., Cheng, F., Zhang, E. Y., Zhang-Chen, A., Kleiboeker, S., & Qiu, J. (2023). Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors. Science Advances, 2023, 9(2): eade0869. 

3. Ning, K., Kuz, C.A., Cheng, F., Feng, Z., Yan, Z. & Qiu, J., (2023). Adeno-Associated Virus monoinfection induces a DNA damage response and DNA repair that contributes to viral DNA replication. mBio, pp.e03528-22.

4. Ning, K., Wang, Z., Cheng, F., Yan, Z., & Qiu, J. (2022). The small nonstructural protein NP1 of human bocavirus 1 directly interacts with Ku70 and RPA70 and facilitates viral DNA replication. PLoS Pathogens, 18(6): e1010578. 

5. Ning, K., Roy, A., Cheng, F., Kleiboeker, S., & Qiu, J. (2021). High throughput screening identifies inhibitors for parvovirus B19 infection of human erythroid progenitor cells. Journal of Virology, 96(2), e01326-21.

6. Ning, K., Zhang, X., Feng, Z., Hao, S., Kuz, C.A., Cheng, F., Park, S.Y., McFarlin, S., Engelhardt, J.F., Yan, Z. and Qiu, J., (2023). Inhibition of DNA-dependent protein kinase catalytic subunit boosts rAAV transduction of polarized human airway epithelium. Molecular therapy. Methods & clinical development, 31. 

7. Zou, W., Ning, K., Xu, P., Deng, X., Cheng, F., Kleiboeker, S., & Qiu, J. (2021). The N-terminal 5-68 amino acids domain of the minor capsid protein VP1 of human parvovirus B19 enters human erythroid progenitors and inhibits B19 infection. Journal of Virology, 95(14), e00466-21.（contributed equally）

8. Ning, K., Liang, T., Wang, M., Dong, Y., Qu, S., & Zhang, D. (2018). Pathogenicity of a variant goose parvovirus, from short beak and dwarfism syndrome of Pekin ducks, in goose embryos and goslings. Avian Pathology, 47(4), 391-399. 

9. Ning, K., Wang, M., Qu, S., Lv, J., Yang, L., & Zhang, D. (2017). Pathogenicity of Pekin duck-and goose-origin parvoviruses in Pekin ducklings. Veterinary Microbiology, 210, 17-23.

10. Ning, K., Liang, T., Wang, M., Dong, Y., Qu, S., & Zhang, D. (2017). Genetic detection and characterization of goose parvovirus: Implications for epidemiology and pathogenicity in Cherry Valley Pekin ducks. Infection, Genetics and Evolution, 51, 101-103.

11. Hao, S., Zhang, X., Ning, K., Feng, Z., Park, S.Y., Kuz, C., McFarlin, S., Richart, D., Cheng, F., Zhang, E., Chen, A., Yan, Z., & Qiu, J. (2023). Identification of host essential factors for recombinant AAV transduction of the polarized human airway epithelium. Journal of Virology, e01330-23.

12. Hao, S., Ning, K., Kuz, C., Xiong, M., Zou, W., Park, SY., McFarlin, S., Yan, Z., Qiu, J. (2023). "SARS-CoV-2 infection of polarized human airway epithelium induces necroptosis that causes airway epithelial barrier dysfunction." Journal of Medical Virology. 95(9): e29076.

13. Hao, S., Ning, K., Kuz, C., McFarlin, S., Cheng, F., & Qiu, J. (2022). Eight years of research advances in Bourbon virus, a tick-borne Thogotovirus of the Orthomyxovirus family. Zoonoses. Vol. 2(1). DOI: 10.15212/ZOONOSES-2022-0012.

14. Shao, L., Ning, K., Wang, J., Cheng, F., Wang, S., & Qiu, J. (2022). The large nonstructural protein (NS1) of the human bocavirus 1 (HBoV1) directly interacts with Ku70, which plays an important role in virus replication in human airway epithelia. Journal of Virology, 96(4), e01840-21.

15. Shen, W., Wang, Z., Ning, K., Cheng, F., Engelhardt, J. F., Yan, Z., & Qiu, J. (2021). Hairpin transfer-independent parvovirus DNA replication produces infectious virus. Journal of Virology, 95(20), e01108-21.

16. Hao, S., Ning, K., Kuz, C. A., Vorhies, K., Yan, Z., & Qiu, J. (2020). Long-term modeling of SARS-CoV-2 infection of in vitro cultured polarized human airway epithelium. mBio, 11(6), e02852-20.

17. Hao, S., Ning, K., Wang, X., Wang, J., Cheng, F., Ganaie, S. S., Tavis, JE., & Qiu, J. (2020). Establishment of a replicon reporter of the emerging tick-borne Bourbon virus and use it for evaluation of antivirals. Frontiers in Microbiology, 11, 572631.

18. Wang, J., Ganaie, S. S., Cheng, F., Xu, P., Ning, K., Wang, X., Kleiboeker, S., Cheng, S., & Qiu, J. (2020). RNA binding motif protein RBM45 regulates expression of the 11-kilodalton protein of parvovirus B19 through binding to novel intron splicing enhancers. mBio, 11(2), e00192-20.

19. Wang, X., Xu, P., Cheng, F., Li, Y., Wang, Z., Hao, S., Wang, J., Ning, K., Ganaie, S., Engelhardt, J., Yan, Z., & Qiu, J. (2020). Cellular cleavage and polyadenylation specificity factor 6 (CPSF6) mediates nuclear import of human bocavirus 1 NP1 protein and modulates viral capsid protein expression. Journal of Virology, 94(2), e01444-19.

20. Jin, M., Wang, X., Ning, K., Liu, N., & Zhang, D. (2018). Genetic characterization of a new astrovirus in goslings suffering from gout. Archives of Virology, 163(10), 2865-2869.

21. Wang, F., Liang, T., Liu, N., Ning, K., Yu, K., & Zhang, D. (2017). Genetic characterization of two novel megriviruses in geese. Journal of General Virology, 98(4), 607-611.

22. Zheng, X., Wang, D., Ning, K., Liang, T., Wang, M., Jiang, M., & Zhang, D. (2016). A duck reovirus variant with a unique deletion in the sigma C gene exhibiting high pathogenicity in Pekin ducklings. Virus Research, 215, 37-41.

23. Liang, T., Liu, X., Cui, S., Qu, S., Wang, D., Liu, N., Wang, F., Ning, K., Zhang, B., & Zhang, D. (2016). Generation of a reliable full-length cDNA of infectious Tembusu virus using a PCR-based protocol. Virus Research, 213, 255-259.

24. Wang, X., Liu, N., Wang, F., Ning, K., Li, Y., & Zhang, D. (2014). Genetic characterization of a novel duck-origin picornavirus with six 2A proteins. Journal of General Virology, 95(6), 1289-1296.