Faculty

Home> Faculty> Preventive Veterinary Medicine

Preventive Veterinary Medicine

Shijun J. Zheng, DVM, PhD

Professor of Microbiology and Immunology

sjzheng@cau.edu.cn

010-62734681

Education

  • 08/1996-11/2000, Ph.D. University of Massachusetts Amherst, Professors Douglas Freeman/ Samuel Black/Cynthia Baldwin

  • 09/1987-07/1990, MS in Preventive Veterinary Medicine, Beijing Agricultural University, Professor Menghou Gan, Beijing

  • 09/1982-07/1987, DVM, Beijing Agricultural University, Beijing


Training and Professional Experience

  • 2005-present, Professor, China Agricultural University College of Veterinary Medicine.

  • 2010-2015, Professor and Associate Dean of China Agricultural University College of Veterinary Medicine.

  • 2000-2005, Postdoctoral Fellow in Molecular Immunology, University of Pennsylvania School of Medicine. 

  • 1993-1996, Senior Lecturer of Immunology, China Agricultural University College of Veterinary Medicine.

  • 1990-1993, Lecturer of Immunology, China Agricultural University College of Veterinary Medicine.


Research Interests

His research interest is primarily focused on the mechanisms of interaction between pathogens and hosts. Currently he is working on: 1) the mechanisms underlying host response against pathogens; 2) the mechanisms of persistent infection and immune escape by pathogens; and 3) development of novel vaccines using molecular biological approaches.


Awards and Honors

  • 2020, "New Century Hundreds and Thousands Talent Program of National Candidate", China

  • 2017, National Distinguished Young Investigator, China

  • 2018, National Distinguished Individual of Returned Oversee Chinese-Awarded by Dept. of the State Oversee Chinese Council

  • 2010-now, Distinguished and Outstanding Teaching Award by Chinese Academy of Agricultural Science. 


Teaching

  • 2016-now, Undergraduate course "Microbiology of Animal Science-Immunology section"

  • 2006-now, Graduate level course "Veterinary Molecular Immunology"

  • 2020-now, Graduate level course "Immunological Control and Therapy"

  • 2006-2017, Graduate level course "Veterinary Special English"


Reviewer for

  • J Immunology, J Virology, mBio, J Biol Chem, Virus Research, Vet Microbiology, F Microbiology, F Immunology, poultry Sci, etc.


Service

  • 2010-present, Associate Editor-in-Chief for the Chinese Journal of Veterinary Medicine

  • 2013-present, Editor-in-Chief for the journal Asian Case Reports in Veterinary Medicine

  • 2019-present, Editor-in-Chief for the journal Enliven: Immunology and Immunobiotechniques

  • 2014-present, Editorial board member for the journal Enliven: Immunology and Immunobiotechniques

  • 2014-present, Editorial board member for the journal Frontier in Agri Sci and Engineering

  • 2012-present, Reviewer editorial board member for the journal Frontier in Microbiology


Selected Publications

Periodical Papers

  • Li J, Hayrat A, Zhou L, Gao L, Chen J, Wang Y, Gao L, Cao H, Li XQ*, and Zheng SJ*. GATA3 inhibits viral infection by promoting the expression of MicroRNA-155. J Virology 2022, (in press)

  • Zhou L, Li J, Hayrat A, Li XQ, Gao L, Cao H, Wang Y*, and Zheng SJ*. Gga-miR-29a-3p Suppresses Avian Reovirus-Induced Apoptosis and Viral Replication via Targeting Caspase-3. Vet Microbiology 2022 (in press)

  • Zhao D, Li J, Wang Y, Li X, Gao L, Cao H, and Zheng SJ*. Critical role for G3BP1 in infectious bursal disease virus (IBDV)-induced stress granule formation and viral replication. Vet Microbiology 2020, 248: 108806. doi.org/10.1016/j.vetmic.2020.108806.

  • Li J and Zheng SJ*. Role of microRNAs in host defense against infectious bursal disease virus (IBDV) infection: a hidden front line. Viruses 2020, May 14, 12(543): 1-18. doi: 10.3390/v12050543. (Invited review)

  • Duan X, Zhao M, Li X, Gao L, Cao H, Wang Y*, and Zheng SJ*. gga-miR-27b-3p Enhances Type I Interferon Expression and Suppresses Infectious Bursal Disease Virus Replication via Targeting Cellular Suppressors of Cytokine Signaling 3 and 6 (SOCS3 and 6). Virus Research 2020, Feb 29: 197910. doi: 10.1016/j.virusres.2020.197910. PMID: 32126296

  • Duan X, Zhao M, Wang Y, Li X, Cao H, and Zheng SJ*. Epigenetic upregulation of chicken microRNA-16-5p expression in DF-1 cells following infection with Infectious Bursal Disease Virus (IBDV) enhances IBDV-induced apoptosis and viral replication. J Virology 2020, 94(2). pii: e01724-19. doi: 10.1128/JVI.01724-19. 

  • Zhao M, Duan X, Wang Y, Gao L, Cao H, Li X*, and Zheng SJ*. A novel role for PX, a structural Protein of Fowl Adenovirus Serotype 4 (FAdV4), as an Apoptosis-inducer in Leghorn Male Hepatocellular Cells. Viruses 2020, Feb 18;12(2). pii: E228. doi: 10.3390/v12020228.

  • Zhou L and Zheng SJ* The roles of microRNAs(miRNAs) in avian response to viral infection and pathogenesis of avian immunosuppressive diseases. IJMS 2019, Nov 1;20(21). pii: E5454. doi: 10.3390/ijms20215454. (Invited review)

  • Gao J, Zhao M, Duan X, Wang Y, Cao H, Li X* and Zheng SJ* Requirement of cellular protein CCT7 for the replication of fowl adenovirus serotype 4 (FAdV-4) in leghorn male hepatocellular cells via interaction with the viral hexon protein. Viruses 2019, 11, 107; doi: 10.3390/v11020107.

  • He Z, Chen X, Fu M, Tang J, Li X, Cao H, Wang Y*, and Zheng SJ*.Inhibition of fowl adenovirus serotype 4 replication in Leghorn male hepatoma cells by SP600125 via blocking JNK MAPK pathway. Vet Microbiology 2019, 228: 45-52.

  • Gao J, Duan X, Li XQ, Cao H, Wang Y* and Zheng SJ* Emerging of A Highly Pathogenic and Multi-drug resistant Strain of Escherichia Coli Causing an outbreak of Colibacillosis in Chickens, Infection, Genetics and Evolution 2018, 65: 392-398.

  • Fu M, Wang B, Chen X, He Z, Wang Y, Li X, Cao H, Zheng SJ*. gga-miR-454 suppresses infectious bursal disease virus (IBDV) replication via directly targeting IBDV genomic segment B and cellular Suppressors of Cytokine Signaling 6 (SOCS6). Virus Research 2018, July 2, 252: 29-40. doi: 10.1016/j.virusres.2018.05.015. [Epub ahead of print]

  • Wang B, Fu M, Liu Y, Wang Y, Li X, Cao H, and Zheng SJ* gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK. Front Cell Infect Microbiol 2018, March 7, 8(55); 1-13, doi: 10.3389/fcimb.2018.00055

  • Chen X, He Z, Fu M, Wang Y, Wu H, Li X, Cao H, and Zheng SJ* The E3 ubiquitin ligase Siah-1 suppresses avian reovirus infection by targeting p10 for degradation, J Virology 2018, Jan 10. 92(6). pii: e02101-17. doi: 10.1128/JVI.02101-17.

  • Wang B, Duan X, Fu M, Liu Y, Wang Y, Li X, Cao H, and Zheng SJ* The Association of Ribosomal Protein L18 (RPL18) with IBDV VP3 Enhances Viral Replication, Virus Research 2018, Feb 2;245: 69-79.

  • He Z, Chen X, Fu M, Tang J, Li X, Cao H, Wang Y*, and Zheng SJ*. Infectious bursal disease virus protein VP4 suppresses, type I interferon expression via inhibiting K48-linked ubiquitylation of glucocorticoid-induced leucine zipper (GILZ), Immunobiology 2018, Apr – May, 223(4-5):374-382.

  • Fu M, Wang B, Chen X, He Z, Wang Y, Li X, Cao H, Zheng SJ*. gga-miR-454 suppresses infectious bursal disease virus (IBDV) replication via directly targeting IBDV genomic segment B and cellular Suppressors of Cytokine Signaling 6 (SOCS6). Virus Research 2018, July 2, 252: 29-40. 

  • Wang B, Fu M, Liu Y, Wang Y, Li X, Cao H, and Zheng SJ* gga-miR-155 Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease Virus Replication via Targeting SOCS1 and TANK. Front Cell Infect Microbiol 2018, March 7, 8(55); 1-13.

  • Chen X, He Z, Fu M, Wang Y, Wu H, Li X, Cao H, and Zheng SJ* The E3 ubiquitin ligase Siah-1 suppresses avian reovirus infection by targeting p10 for degradation, J Virology 2018, Jan 10. 92(6). pii: e02101-17. 

  • Wang B, Duan X, Fu M, Liu Y, Wang Y, Li X, Cao H, and Zheng SJ* The Association of Ribosomal Protein L18 (RPL18) with IBDV VP3 Enhances Viral Replication, Virus Research 2018, Feb 2;245:69-79.

  • He Z, Chen X, Fu M, Tang J, Li X, Cao H, Wang Y, and Zheng SJ*. Infectious bursal disease virus protein VP4 suppresses, type I interferon expression via inhibiting K48-linked ubiquitylation of glucocorticoid-induced leucine zipper (GILZ), Immunobiology 2018, 223(4-5):374-382.

  • Fu M, Wang B, Chen X, He Z, Wang Y, Li X, Cao H, and Zheng SJ*, gga-miR-130b suppresses infectious bursal disease virus replication via targeting the viral genome and cellular SOCS5, J Virology 2017 Dec 14;92(1). pii: e01646-17. doi: 10.1128/JVI.01646-17. 

  • Qin Y, Xu Z, Wang Y, Li X, Cao H, and Zheng SJ*, VP2 of Infectious Bursal Disease Virus induces apoptosis via triggering Oral Cancer Overexpressed 1 (ORAOV1) protein degradation. Frontiers in Microbiology 2017, July, 8(1): doi: 10.3389/fmicb.2017.01351

  • Li X, Liu Y, Wang Y, Liu J, Li XQ, Cao H, Gao X and Zheng SJ*, Negative regulation of hepatic inflammation by the Soluble Resistance-Related Calcium Binding Protein via STAT3. Frontier in Immunology 2017, June 29, 8: 1-14 

  • Qin Y and Zheng SJ* .Infectious Bursal Disease Virus-Host Interactions: Multifunctional Viral Proteins that Perform Multiple and Differing Jobs. International J of Molecular Sciences 2017, 18, 161; doi:10.3390/ijms18010161

  • Xu Z, Qin Y, Wang Y, Li X, Cao H, and Zheng SJ*,  A Critical role of bacterioferritin in Salmonella pullorum-induced IFN-β expression in DF-1 cells, Frontiers in Microbiology 2016, 7(1): doi: 10.3389/fmicb.2016.00020

  • Wu H, H Z, Tang J, Li X, Cao H, Wang Y*, and Zheng SJ* A critical role of LAMP-1 in avian reovirus P10 degradation associated with inhibition of apoptosis and virus release. Arch Virol 2016, 161: 899–911

  • Lin W, Zhang Z, Xu Z, Wang B, Li XQ, Cao H, Wang Y*, and Zheng SJ*. The Association of Receptor of Activated Protein Kinase C 1（RACK1）with Infectious Bursal Disease Virus Protein VP5 and VDAC2 Inhibits Apoptosis and Enhances Viral Replication. J Biol Chem. 2015, 290(13): 8500-10.

  • Li X, Wang J, Liu J, Li Z, Wang Y, Xue Y, Li XQ, Cao H, and Zheng SJ*. Engagement of Soluble Resistance-Related Calcium Binding Protein (sorcin) with foot-and-mouth disease virus (FMDV) VP1 inhibits type I interferon response in cells, Vet Microbiology 2013, 166: 35–46. 

  • Li Z, Wang Y, Li X, Li XQ, Cao H, and Zheng SJ*. Critical Roles of Glucocorticoid-Induced Leucine Zipper in Infectious Bursal Disease Virus (IBDV)-induced Suppression of Type I Interferon Expression and Enhancement of IBDV Growth in Host Cells via Interaction with VP4. Journal of Virology 2013, 87(2): 1221-1231. 

  • Li X, Li XQ, Cao H, Wang Y, and Zheng SJ*. Engagement of new castle disease virus (NDV) matrix (M) protein with charged multivesicular body protein (CHMP) 4 facilitates viral replication. Virus Research 2013, 171: 80-88. 

  • Wang J, Wang Y, Liu J, Ding L, Zhang Q, Li X, Cao H, Tang J, and Zheng SJ*. A critical role of N-myc and STAT interactor (Nmi) in foot-and-mouth disease virus (FMDV) 2C-induced apoptosis. Virus Research 2012, 170(2012) 59– 65.

  • Luo Z, Li Z, Chen K, Liu R, Li X, Cao H, and Zheng SJ*. Engagement of Heterogeneous Nuclear Ribonucleoprotein M with Listeriolysin O Induces Type I Interferon Expression and Restricts Listeria Monocytogenes Growth in Host Cells. Immunobiology 2012, 217(10): 972-981. 

  • Li Z, Wang Y, Xue Y, Li X, Cao H, and Zheng SJ*. A critical role for voltage-dependent anion channel (VDAC) 2 in infectious bursal disease virus (IBDV)-induced apoptosis in host cells via interacting with VP5. Journal of Virology 2012, 86(3): 1328-1338.

  • Li H, Wang Y, Ding L, and Zheng SJ*. Staphylococcus sciuri exfoliative toxin C (ExhC) is a necrosis-inducer for mammalian cells. PLoS ONE 2011, 6(7): e23145: 1-9. 

  • Chen K, Luo Z, Tang J*, Zheng SJ*. A critical role of heat shock cognate protein 70 in Apoptin-induced phosphorylation of Akt. Biochem Biophys Res Commun. 2011 Jun 3; 409(2): 200-4.

  • Wang Y, Lu Y, Duo Y, Wang Y,Chen F,Yang H*, Zheng SJ*. Enhanced resistance of restraint stressed mice to sepsis. Journal of Immunology 2008, 181: 3441-3448.

  • Chen S, Wang Y, Chen F, Yang H, Menghou Gan and Zheng SJ*. A highly pathogenic strain of Staphylococcus sciuri caused fatal exudative epidermitis in piglets. PLoS ONE 2007, 2(1)e147: 1-6. 

  • Zheng SJ, L-Cherradi S, Wang P, Xu LY and Chen YH. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes 2005, 54: 1423-1428.

  • Zheng SJ, Jiang J., Shen H., and Chen YH. Reduced apoptosis and listeriosis in TRAIL-null mice. Journal of Immunology 2004, 173: 5652-5658.

  • Zheng SJ, Wang P., Tsabary G. and Chen YH. Critical role of TRAIL in hepatic cell death and hepatic inflammation. Journal of Clinical Investigation 2004, 113(1): 58-64.

  • L-Cherridi S*, Zheng SJ*(*Co-first author), Maguaschak, KA and Chen YH. Defective thymocyte apoptosis and accelerated autoimmunune diseases in TRAIL-Null mice. Nature Immunology 2003, 4(3): 255-260.  *Note: The first two authors contributed equally to this study.

  • Zheng SJ and Chen YH. TRAIL, Bim and thymic negative selection. Immunological Research 2003, 28/3: 293-299.

Books and Chapters

  • Zheng SJ, Author for the Text book《Veterinary Molecular Immunology》-second edition in Chinese, 55.5 thousand words in total. September 2021，China Agricultural Press.

  • Zheng SJ, Chapter 7: Infectious Bursal Disease Virus, in the book《Avian Virology-Current Research and Future Trends》, 2019, eds (SK. Samal, Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD, USA), published by Caister Academic Press, UK. https://doi.org/10.21775/9781912530106.07

  • Zheng SJ, Author for the Text book《Veterinary Molecular Immunology》in Chinese, 33.5 thousand words in total. September 2015 for the first press and 2018 for the second press, China Agricultural Press.

  • Zheng SJ and Song QM, Editor-in-chief for the book《Current Infectious Diseases》in Chinese,1.44million words in total. December 2013. China Agricultural Press.