Pinghuang Liu, DVM, PhD

Education

• 01/2002-12/2005, PhD in Veterinary Medicine, North Carolina State University

• 09/1998-07/2001, MS in Preventive Veterinary Medicine, China Agricultural University

• 09/1994-07/1998, DVM, China Agricultural University

Training and Professional Experience

• 2020-now, Professor, China Agricultural University College of Veterinary Medicine

• 2014-2019, Professor, Harbin Veterinary Research Institute (HVRI) of the Chinese Academy of Agricultural Sciences (CAAS)

• 2009-2014, Senior Research Associate, Human Vaccine Institute, Duke University

• 2006-2009, Postdoctoral Fellow, Department of Surgery, Duke University

Research Interests

Liu 's Lab current research interest focuses on the pathogenesis and host immune responses of animal coronaviruses with an aim to promote animal and human health. 

Teaching

• 2022-now, Undergraduate course “Veterinary Microbiology” 

Reviewer for

• Journal of Virology

• Virology

• Viruses

• Frontiers in Immunology

Service

• 2019-Now, Editorial Board Member of Frontiers in Microbiology

Selected Publications

• Zhao L, Li L, Xue M, Liu X, Jiang C, Wang W, Tang L#, Feng L#, Liu Pinghuang#. Gasdermin D Inhibits Coronavirus Infection by Promoting the Noncanonical Secretion of Beta Interferon. mBio. 2022 Feb 1;13(1):e0360021. doi: 10.1128/mbio.03600-21.

• Yin L, Liu X, Hu D, Luo Y, Zhang G, Liu Pinghuang#. Swine Enteric Coronaviruses (PEDV, TGEV, and PDCoV) Induce Divergent Interferon-Stimulated Gene Responses and Antigen Presentation in Porcine Intestinal Enteroids. Front Immunol. 2022 Jan 20;12:826882. doi: 10.3389/fimmu.2021.826882.

• Li T, Kan Q, Ge J, Wan Z, Yuan M, Huang Y, Xie Q, Yang Y, Shao H, Li X, Ye L, Qin A#, Bu Z#, Liu Pinghuang#, Ye J#. A novel linear and broadly neutralizing peptide in the SARS-CoV-2 S2 protein for universal vaccine development. Cell Mol Immunol. 2021 Nov;18(11):2563-2565. doi: 10.1038/s41423-021-00778-6. Epub 2021 Oct 13.

• Li R*, Pan Z*, Wu J*, Yue S, Lin Y, Yang Y, Li Z, Hu L, Tang J, Shan L, Tian Q, Jiang P, Wei P, Ye L#, Liu Pinghuang#, Chen X#. The epigenetic regulator EZH2 instructs CD4 T cell response to acute viral infection via coupling of cell expansion and metabolic fitness. J Virol. 2020 Sep 30:JVI.01627-20. doi: 10.1128/JVI.01627-20. 

• Yin L*, Chen J*, Li L, Guo S, Xue M, Zhang J, Liu X, Feng L#, Liu Pinghuang#. Aminopeptidase N Expression, Not Interferon Responses, Determines the Intestinal Segmental Tropism of Porcine Deltacoronavirus. J Virol. 2020 Jul 1;94(14):e00480-20. doi: 10.1128/JVI.00480-20. 

• Liang Li*, Mei Xue, Fang Fu, Lingdan Yin, Li Feng#, Liu Pinghuang#. IFN-Lambda 3 Mediates Antiviral Protection Against Porcine Epidemic Diarrhea Virus by Inducing a Distinct Antiviral Transcript Profile in Porcine Intestinal Epithelia. Frontiers in Immunology. 2019 Oct. 

• Ren Li*, Fang Fu, Li Feng#, Liu Pinghuang. Next-generation sequencing and single-cell RT-PCR reveal a distinct variable gene usage of porcine antibody repertoire following PEDV vaccination. Sci. China Life Sci. 2019 Jul 17. doi: 10.1007/s11427-019-9576-2.

• Liang Li*, Fang Fu *, Shanshan Guo, Hongfeng Wang, Xijun He, Mei Xue, Lingdan Yin, Li Feng, Liu Pinghuang#. Porcine Intestinal Enteroids: a New Model To Study Enteric Coronavirus PEDV Infection and Host Innate Response. Journal of Virology. 2019 Feb 19;93(5). 

• Yanlong Ma*, Changlin Wang*, Mei Xue, Fang Fu, Xin Zhang, Liang Li, Lingdan Yin, Wanhai Xu, Li Feng#, Liu Pinghuang#. Coronavirus TGEV Evades Type I Interferon Response through IRE1 Mediated Manipulation of miR-30a-5p/SOCS1/3 Axis. Journal of Virology. 2018 Oct 29;92(22). 

• Mei Xue*, Fang Fu, Yanlong Ma, Xin Zhang, Liang Li, Li Feng#, Liu Pinghuang#. The PERK Arm of the Unfolded Protein Response Negatively Regulates Transmissible Gastroenteritis Virus Replication by Promoting Type I IFN Production. Journal of Virology. 2018 Jul 17;92(15).