Guozhong Zhang, DVM, PhD

Education

• 09/2003-07/2006, PhD in Animal Infectious Diseases, College of Veterinary Medicine, China Agricultural University

• 09/1998-07/2001, MS in Animal Infectious Diseases, College of Veterinary Medicine, China Agricultural University

• 09/1994-07/1998, DVM, College of Veterinary Medicine, China Agricultural University

Training and Professional Experience

• 2012-now, Professor, College of Veterinary Medicine, China Agricultural University

• 2001-2012, Teaching Assistant/Lecturer/Associate Professor, College of Veterinary Medicine, China Agricultural University

Research Interests

• Diagnosis and Control of Animal Infectious Diseases; Animal Virology

Awards and Honors

• 2010, Program for New Century Excellent Talents in University, China

Teaching

• 2019-now, Undergraduate course "Animal Infectious Diseases"

• 2019-now, Undergraduate course "Introduction to Veterinary Medicine"

• 2018-now, Doctoral course "Advances in Veterinary Science"

Reviewer for

• Antiviral Research

• Virology

• Veterinary Microbiology

Service

• 2019-Now, Editor-in-Chief of Veterinary Science Research

• 2019-Now, Associate Editor of Chinese Journal of Veterinary Medicine

Selected Publications

• Zhao J, Sun L, Zhao Y, Feng DL, Cheng JL, Zhang GZ*. 2021. Coronavirus endoribonuclease ensures efficient viral replication and prevents protein kinase R activation. Journal of Virology 95(7): e02103-20.

• Yang YL, Xue J, Teng QY, Li X, Bu YW, Zhang GZ*. 2021. Mechanisms and consequences of Newcastle disease virus W protein subcellular localization in the nucleus or mitochondria. Journal of Virology 95(7):e02087-20.

• Cheng JL, Zhao Y, Hu YX, Zhao J, Xue J, Zhang GZ*. 2021. The furin-S2' site in avian coronavirus plays a key role in central nervous system damage progression. Journal of Virology 95(11):e02447-20.

• Qin YF, Tu KH, Teng QY, Feng DL, Zhao Y, Zhang GZ*. 2021. Identification of Novel T-Cell Epitopes on Infectious Bronchitis Virus N Protein and Development of a Multi-epitope Vaccine. Journal of Virology 95(17):e0066721.

• Wu YF, Wang Y, Yang HM, Li Q, Gong X, Zhang GZ*, Zhu K*. 2021. Resident bacteria contribute to opportunistic infections of the respiratory tract. PLoS Pathogens 17(3):e1009436.

• Gao L, Zhou J, Yang S, Wang L, Chen X, Yang Y, Li R, Pan Z, Zhao J, Li Z, Huang Q, Tang J, Hu L, Liu P, Zhang G*, Chen Y*, Ye L*. 2021. The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity. Signal Transduction and Targeted Therapy 6(1):113.

• Shao L, Zhao J, Li LH, Huang XY, Yang HM, Cheng JL, Liu CQ, Zhang GZ*. 2020. Pathogenic characteristics of a QX-like infectious bronchitis virus strain SD in chickens exposed at different ages and protective efficacy of combining live homologous and heterologous vaccination. Veterinary Research 51:86.

• Zhao J, Zhang KR, Cheng J, Jia WF, Zhao Y, Zhang GZ*. 2020. Replicase 1a gene plays a critical role in pathogenesis of avian coronavirus infectious bronchitis virus. Virology 550:1-7.

• Chen X, Pan Z, Yue S, Yu F, Zhang J, Yang Y, Li R, Liu B, Yang X, Gao L, Li Z, Lin Y, Huang Q, Xu L, Tang J, Hu L, Zhao J, Liu P, Zhang G*, Chen Y*, Deng K*, Ye L*. 2020. Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19. Signal Transduction and Targeted Therapy 5(1):180.

• Yang YL, Bu YW, Zhao J, Xue J, Xu G, Song Y, Zhao Y, Yang HM, Zhang GZ*. 2019. Appropriate amount of W protein of avian avulavirus 1 benefits viral replication and W shows strain-dependent subcellular localization. Virology 538:71-85.

• Cheng JL, Zhao Y, Xu G, Zhang KR, Jia WF, Sun YL, Zhao J, Xue J, Hu YX, Zhang GZ*. 2019. The S2 subunit of QX-type infectious bronchitis coronavirus spike protein is an essential determinant of neurotropism. Viruses 11:972.

• Zhao Y, Cheng JL, Yan SH, Jia WF, Zhang KR, Zhang GZ*. 2019. S gene and 5a accessory gene are responsible for the attenuation of virulent infectious bronchitis coronavirus. Virology 533:12-20.

• Song Y, Pei Y, Yang YL, Xue J, Zhang GZ*. 2019. The Ntail region of nucleocapsid protein is associated with the pathogenicity of pigeon paramyxovirus type 1 in chickens. Journal General Virology 100(6):950-957.

• Cheng JL, Huo CY, Zhao J, Liu T, Li X, Yan SH, Wang Z, Hu YX, Zhang GZ*. 2018. Pathogenicity differences between QX-like and Mass-type infectious bronchitis viruses. Veterinary Microbiology 213:129-135.

• Yan SH, Liu XY, Zhao J, Xu G, Zhao Y, Zhang GZ*. 2017. Analysis of antigenicity and pathogenicity reveals major differences among QX-like infectious bronchitis viruses and other serotypes. Veterinary Microbiology 203:167-173.

• Yu XH, Cheng JL, He ZR, Li C, Song Y, Xue J, Yang HM, Zhang R, Zhang GZ*. 2017. The glutamic residue at position 402 in the C-terminus of Newcastle disease virus nucleoprotein is critical for the virus. Scientific Reports 7(1):17471

• Yang HM, Zhao J, Xue J, Yang YL, Zhang GZ*. 2017. Antigenic variation of La Sota and genotype VII Newcastle disease virus (NDV) and their efficacy against challenge with velogenic NDV. Vaccine 35(1):27-32.

• Jin JH, Zhao J, Ren YC, Zhong Q, Zhang GZ*. 2016. Contribution of HN protein length diversity to Newcastle disease virus virulence, replication and biological activities. Scientific Reports 6:36890.

• Zhao Y, Zhang H, Zhao J, Zhong Q, Jin JH, Zhang GZ*. 2016. Evolution of infectious bronchitis virus in China over the past two decades. Journal General Virology 97:1566-74.

• Feng JL, Hu YX, Ma ZJ, Yu Q, Zhao JX, Liu XD, Zhang GZ*. 2012. Virulent avian infectious bronchitis virus, People's Republic of China. Emerging Infectious Diseases 18(12):1994-2001.