Lei Zhou, PhD

Education

• 09/2005-07/2010, Ph.D. in Veterinary Molecular Virology & Immunology, College of Veterinary Medicine, China Agricultural University

• 09/2000-07/2005, D.V.M., Veterinary Medicine, College of Veterinary Medicine, China Agricultural University

Training and Professional Experience

• 2019-now, Associate Director of Veterinary Diagnosis and Research Center of China Agricultural University

• 2015-now, Associate Professor of Veterinary Molecular Virology & Immunology, College of Veterinary Medicine, China Agricultural University

• 2011-2014, Assistant Professor of Veterinary Molecular Virology & Immunology, 
College of Veterinary Medicine, China Agricultural University

• 2011-2013, Postdoctoral Associate, Molecular Virology
Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine Virginia Polytechnic Institute and State University

• 2010-2011, Research Specialist, Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University

• 2005-2010, Graduate Research Assistant
, Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University

Research Interests

• Pathogenicity, replication fidelity, molecular epidemiology and immune protection mechanism of porcine reproductive and respiratory syndrome virus (PRRSV)

Awards and Honors

• 2021, Outstanding Supervisor Award for "100 Excellent Graduation Thesis" of Undergraduates of China Agricultural University

• 2017, Outstanding Supervisor Award for "100 Excellent Graduation Thesis" of Undergraduates of China Agricultural University

• 2016, Outstanding Young Researcher Award of Dabeinong

• 2016, Boehringer Ingelheim's Awards for Advancing Research in PRRS

• 2012, National Top100 Excellent Doctoral Dissertation Award, China

• 2011, Excellent Doctoral Dissertation Award in Beijing

• 2010, Top10 Excellent Doctoral Dissertation Award in China Agriculture University

• 2010, Boehringer Ingelheim Scholarship for Excellent Graduated Students in Collage of Veterinary Medicine

Teaching

• 2013-now, Undergraduate course "Veterinary Microbiology"

• 2013-now, Ph.D. course "Prevent Veterinary Medicine Seminar"

Reviewer for

• Transboundary and Emerging Diseases

• Virology Journal

• Frontier of Veterinary Medicine

• Veterinary Microbiology

Service

• Vice chairman and secretary-general of the Youth Committee of the Veterinary Microbiology Committee of the Chinese Society of Microbiology

• Vice secretary-general of the Branch of Pig Science, Chinese Association of Animal Science and Veterinary Medicine

• Assessment expert of National Animal Disease Eradication Program of China Animal Disease Control Center

Selected Publications

• Wu Weixin, Ge Xinna; Zhang Yongning, Han Jun, Guo Xin, Zhou Lei* ^co, Yang Hanchun* ^co. Evolutionary Patterns of Codon Usage in Major Lineages of Porcine Reproductive and Respiratory Syndrome Virus in China, Viruses. 2021. 13, no. 6: 1044.

• Zhou Lei, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A "Leaky" Vaccine with Debatable Efficacy and Safety. Vaccines. 2021;9:362.

• Zhou X, Ge X, Zhang Y, Han J, Guo X, Chen Y, Zhou Lei* ^co, Yang, H* ^co. Attenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model. Virulence. 2021; 12:1011-21.

• Zhou, X^co, Zhou Lei^co, Zhang, P, Guo, X., Han, J. and Yang, H.A strain of porcine deltacoronavirus: Genomic characterization, pathogenicity and its full‐length cDNA infectious clone. Transbound Emerg Dis.2020; 00:1– 17. https://doi.org/10.1111/tbed.13862

• Su, J., Zhang, X., He, B., Ge, X., Han, J., Zhou Lei* ^co, Guo, X* ^co. and Yang, H., 2019. Identification of three site mutations in nonstructural protein 1β, glycoprotein 3 and glycoprotein 5 that correlate with increased interferon α resistance of porcine reproductive and respiratory syndrome virus. Veterinary Microbiology, p.108395.

• Zhang, Z^co, Zhou Lei^co, Ge, X., Guo, X., Han, J. and Yang, H., 2018. Evolutionary analysis of six isolates of porcine reproductive and respiratory syndrome virus from a single pig farm: MLV-evolved and recombinant viruses. Infection, Genetics and Evolution, 66, pp.111-119.

• Jiang Nan; Jin Huan; Li Yi; Ge Xinna; Han Jun; Guo Xin; Zhou Lei*; Yang Hanchun, 2017. Identification of a novel linear B-cell epitope in nonstructural protein 11 of porcine reproductive and respiratory syndrome virus that are conserved in both genotypes, PLos One, 12(11): 0~e0188946

• Cui Zhengzhi; Niu Shuaishuai; Liu Jingjing; Xu Lei; Dai Yunping; Li Ning; Kang Youmin; Zhang Linlin* ^co; Zhou Lei* ^co; Yu Shuyang*co ,2017. Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice, Science Bulletin, 62(24): 1634~1636

• Gao, Xiang, Dongliang Li, Jingyi Zhao, Farong Xu, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang, and Zhou Lei*, 2016. Complete genome sequence of porcine epidemic diarrhea virus from an outbreak in a vaccinated farm in Shandong, China. Genome announcements 4, no. 4 (2016): e00619-16.

• Zhou Lei^co, Yang Beina^co, Xu Lei., Jin, H., Ge, X., Guo, X., Yang, H. 2017. Efficacy evaluation of three modified-live virus vaccines against a strain of porcine reproductive and respiratory syndrome virus NADC30-like. Veterinary Microbiology.

• Han Jun^co, Zhou Lei^co , Yang Hanchun, 2017. Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus. Veterinary Microbiology (2017).

• Zhou Lei^co, Zichun Wang^co, Yuping Ding, Xinna Ge, Xin Guo, Hanchun Yang, 2015. NADC30-like Strain of Porcine Reproductive and Respiratory Syndrome Virus, China. Emerging infectious diseases 21.12 (2015): 2256.

• Li Y^co, Zhou Lei^co, Zhang JL, Ge XN, Zhou R, Zheng HG, Geng G, Guo X, Yang HC. 2014. NSP9 and NSP10 Contribute to the Fatal Virulence of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Emerging in China. PLoS pathogens. 10, e1004216.

• Li Wang^co, Zhou Lei^co, Han Zhang, Yan Li, Xinna Ge, Xin Guo, Kangzhen Yu, Hanchun Yang,2014 Interactome Profile of the Host Cellular Proteins and the Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus. PLoS ONE 9(6): e99176. doi:10.1371/journal.pone.0099176

• Zhou Lei, Xiaorong Yang, Yuan Tian, Xinna Ge, Xin Guo, Hanchun Yang, 2014 Genetic Diversity Analysis of Genotype 2 Porcine Reproductive and Respiratory Syndrome Viruses Emerging in Recent Years in China. BioMed Research International, vol. 2014, Article ID 748068, 13 pages, 2014. doi:10.1155/2014/748068

• Zhou Lei, Ni Y-Y, Piñeyro P, Cossaboom CM, Subramaniam S, Dryman, B., Huang, Y.-W., Cao, D.-J., Meng, X.-J. 2013.Broadening the Heterologous Cross-Neutralizing Antibody Inducing Ability of Porcine Reproductive and Respiratory Syndrome Virus by Breeding the GP4 or M genes. PLoS ONE 8(6): e66645. doi:10.1371/journal.pone.0066645

• Zhou Lei, Ni, Y.-Y., Piñeyro, P., Sanford, B., Cossaboom, C., Dryman, B., Huang, Y.-W., Cao, D.-J., Meng, X.-J., 2012. DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain. Virology 434, 96-109.

• Zhou, Lei, Yang, H., 2010. Porcine reproductive and respiratory syndrome in China. Virus research 154, 31-37.

• Zhou, Lei^co, Chen, S^co., Zhang, J., Zeng, J., Guo, X., Ge, X., Zhang, D., Yang, H., 2009a. Molecular variation analysis of porcine reproductive and respiratory syndrome virus in China. Virus research 145, 97-105.

• Zhou, Lei^co, Zhang, J. ^co, Zeng, J., Yin, S., Li, Y., Zheng, L., Guo, X., Ge, X., Yang, H., 2009b. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. Journal of virology 83, 5156-5167.