Chongshan Dai, PhD

Education

• 09/2013-07/2017, PhD, Basic Veterinary Medicine, China Agricultural University

• 09/2010-07/2013, Master, Basic Veterinary Medicine, Northeast Agricultural University

• 09/2006-07/2010, Bachelor, and Plant Quarantine, Henan University of Science and Technology

Training and Professional Experience

• 2021-now, Associated Professor, China Agricultural University College of Veterinary Medicine

• 2017-2020, Postdoctoral Fellow, Department of Internal Medicine, University of Texas Southwestern Medicine Center

Research Interests

• Cell Death and Metabolic Diseases

• Molecular Toxicology of Antibacterial Drugs

• Risk Assessment of Environmental Hazard Factor (e.g., Heavy Metals, Toxins, etc.)

Awards and Honors

• 2014, 2015, 2016, Postgraduate (PhD) National Scholarship, China (3 Times)

• 2014, Outstanding Paper Award of the Chinese Society of Environmental Mutagens

Teaching

• 2021-now, Undergraduate Course "Animal Toxicology"

• 2021-now, Postgraduate Course "Topics in Veterinary Pharmacology and Toxicology"

Reviewer for

• British of Pharmacology

• Journal of Antimicrobial Chemotherapy

• Antimicrobial Agents and Chemotherapy

Service

• 2020-Now, Editorial Board Member of Evidence-based Complementary and Alternative Medicine

• 2019-Now, Editorial Board Member of International Journal of Functional Nutrition

Selected Publications

• Chongshan Dai#, Qinfeng Li, Herman I May, Chao Li, Guangyu Zhang, Gaurav Sharma, A Dean Sherry, Craig R Malloy, Chalermchai Khemtong, Yuannyu Zhang, Yingfeng Deng, Thomas G Gillette, Jian Xu, David T Scadden, Zhao V Wang*; Lactate dehydrogenase A governs cardiac hypertrophic growth in response to hemodynamic stress. Cell Reports, 2020, 32: 108087.

• Chongshan Dai#, Xilong Xiao, Daowen Li, Sun Tun, Ying Wang, Tony Velkov*, Shusheng Tan*; Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis. Cell Death & Disease, 2018, 26: 1164.

• Tony Velkov#*, Chongshan Dai#, Giuseppe D Ciccotosto, Roberto Cappai, Daniel Hoyer, Jian Li; Polymyxins for CNS infections: pharmacology and neurotoxicity. Pharmacology & Therapeutics, 2018, 181: 85-90.

• Chongshan Dai#, Giuseppe D Ciccotosto, Roberto Cappai, Shusheng Tang, Daowen Li, Sanlei Xie, Xilong Xiao*, Tony Velkov*; Curcumin attenuates colistin-induced neurotoxicity in N2a cells via anti-inflammatory activity, suppression of oxidative stress, and apoptosis. Molecular Neurobiology, 2018, 55: 421-434.

• Chongshan Dai#, Shusheng Tang, Tony Velkov*, Xilong Xiao*. Colistin-induced apoptosis of neuroblastoma-2a cells involves the generation of reactive oxygen species, mitochondrial dysfunction, and autophagy. Molecular Neurobiology, 2016, 53: 4685-700.

• Chongshan Dai#*, Hui Li, Yang Wang, Shusheng Tang, Tony Velkov*, Jianzhong Shen. Inhibition of oxidative stress and alox12 and nf-κb pathways contribute to the protective effect of baicalein on carbon tetrachloride-induced acute liver injury. Antioxidants, 2021,10:976.

• Chongshan Dai#*, Yang Wang, Gaurav Sharma, Jianzhong Shen, Tony Velkov, Xilong Xiao*. Polymyxins-curcumin combination antimicrobial therapy: safety implications and efficacy for infection treatment. Antioxidants, 2020, 9: 506.

• Chongshan Dai#, Xin Chen, Jingbo Li, Paul Comish, Rui Kang*, Daolin Tang*. Transcription factors in ferroptotic cell death. Cancer Gene Therapy, 2020, 27: 645-656. ESI High citation

• Chongshan Dai#, Shusheng Tang, Yang Wang, Tony Velkov, Xilong Xiao*; Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response. Journal of Antimicrobial Chemotherapy, 2017, 72: 2562-2569.

• Chongshan Dai#, Xilong Xiao, Yuan Zhang, Biao Xiang, Daniel Hoyer, Jianzhong Shen, Tony Velkov*, Shusheng Tang*. Curcumin attenuates colistin - induced peripheral neurotoxicity in mice. ACS Infectious Diseases, 2020, 6(4): 715-724. F1000 Prime recommended.