Faculty

Home> Faculty> Preventive Veterinary Medicine

Preventive Veterinary Medicine

Xin Li, PhD

Professor of Comparative Immunology

xinli2021@cau.edu.cn

Education

  • 09/2009-07/2012, PhD in Preventive Veterinary Medicine, China Agricultural University

  • 09/2006-07/2009, MS in Preventive Veterinary Medicine, Harbin Veterinary Research Institute, Chinese Academy of  Agricultural Sciences

  • 09/2001-07/2006, BS in Veterinary Medicine, Northeast Agricultural University


Training and Professional Experience

  • 2021-now, Professor, College of Veterinary Medicine, China Agricultural University

  • 2018-2020, Research Associate, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill

  • 2014-2018, Postdoctoral Fellow, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill

  • 2012-2014, Postdoctoral Fellow, Department of Biochemistry &Biophysics, College of Agriculture & Life Sciences, Texas A&M University


Research Interests

  • Mechanistic basis of how cGAS-STING signaling activates the immune response to cytosolic DNA released during pathogen replication

  • Molecular mechanism of nucleic acid sensing by NOD-like receptors (NLRs) during viral infection


Awards and Honors

  • 2012, Distinguished Graduate Student, China Agricultural University

  • 2011, Scientific Research Achievement Award, China Agricultural University

  • 2011, Best Academic Achievement Award, Doctoral Students Forum on Veterinary Medicine Program in China, Huazhong Agricultural University


Reviewer for

  • Frontiers In Immunology

  • Virology Journal

  • Scientific Reports

  • Molecular Immunology

  • PLOS ONE

  • Virologica Sinica

  • Cancer Medicine


Service

  • Member of the American Association of Immunologists, AAI

  • Member of World Society for Virology


Selected Publications

  • Li X, Deng M, Petrucelli AS, Zhu C, Mo J, Zhang L, Tam JW, Ariel P, Zhao B, Zhang S, Ke H, Li P, Dokholyan NV, Duncan JA, Ting JP. 2019. Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon. Immunity 50:591-599 e6.

  • Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P. 2013. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity 39:1019-31.

  • Li X, Liu J, Qi J, Gao F, Li Q, Li X, Zhang N, Xia C, Gao GF. 2011. Two distinct conformations of a rinderpest virus epitope presented by bovine major histocompatibility complex class I N*01801: a host strategy to present featured peptides. J Virol 85:6038-48.

  • Shu C, Li X, Li P. 2014. The mechanism of double-stranded DNA sensing through the cGAS-STING pathway. Cytokine Growth Factor Rev 25:641-8.

  • Guo H, Chou WC, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gomes ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tan X, Sartor RB, Lu K, Ting JPY. 2020. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science 370.

  • Liu Y, Li X, Qi J, Zhang N, Xia C. 2016. The structural basis of chicken, swine and bovine CD8alphaalpha dimers provides insight into the co-evolution with MHC I in endotherm species. Sci Rep 6:24788.

  • Chang JT, Li X, Liu HJ, Yu L. 2010. Ovine rotavirus strain LLR-85-based bovine rotavirus candidate vaccines: construction, characterization and immunogenicity evaluation. Vet Microbiol 146:35-43.

  • Chen W, Jia Z, Zhang T, Zhang N, Lin C, Gao F, Wang L, Li X, Jiang Y, Li X, Gao GF, Xia C. 2010. MHC class I presentation and regulation by IFN in bony fish determined by molecular analysis of the class I locus in grass carp. J Immunol 185:2209-21.

  • Zhang N, Qi J, Pan X, Chen Z, Li X, Gao F, Xia C. 2011. Crystallization and preliminary X-ray crystallographic studies of swine CD8alpha. Acta Crystallogr Sect F Struct Biol Cryst Commun 67:888-91.