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Preventive Veterinary Medicine

Jun Han, DVM, PhD

Professor of Virology
Associate Dean for Research and International Communications

hanx0158@cau.edu.cn

+8613261334608

Education

  • 09/2003-12/2008, PhD in Animal Virology, University of Minnesota-Twin Cities

  • 09/2000-07/2003, MS in Veterinary Microbiology, China Agricultural University

  • 09/1996-07/2000, DVM, China Agricultural University


Training and Professional Experience

  • 2015-now, Professor, China Agricultural University College of Veterinary Medicine

  • 2009-2015, Postdoctoral Fellow, Department of Microbiology and Immunology, Penn State University College of Medicine


Research Interests

Dr. Han's current research interest focuses on the replication and pathogenesis of nidoviruses (PRRSV and PEDV) and herpesviruses (PRV and HSV-1) with an aim to promote animal and human health through better understanding the viruses.


Awards and Honors

  • 2020, National Distinguished Young Investigator, China

  • 2016, “One-thousand Youth Talents” program, China

  • 2014, Postdoctoral Excellence Award, Penn State College of Medicine

  • 2014, NIH K99 award


Teaching

  • 2016-now, Undergraduate course “Veterinary Microbiology”

  • 2015-now, Graduate level course “Preventive Veterinary Medicine”

  • 2015-now, Graduate level course “Progress in Veterinary Science”

  • 2015-now, Graduate level course “Science of Virology”


Service

  • 2019-Now, Editorial Board Member of Frontiers in Microbiology

  • 2019-Now, Associate Editor of Journal of Veterinary Science

  • Reviewer for Journal of Virology

  • Reviewer for Virology

  • Reviewer for Virus Research

  • Reviewer for Emerging Infectious Diseases

  • Reviewer for Virology Journal

  • Reviewer for Veterinary Microbiology


Selected Publications

  • Zhang W, Gao P, Gui X, Zhou L, Ge X, Guo X, Wills JW, Jun Han*, Hanchun Yang. 2020. Induction of Rod-Shaped Structures by Herpes Simplex Virus Glycoprotein I. Journal of Virology. 2020 Aug 17; 94(17): e00231-20.

  • Peng Gao, Yue Chai, Jiangwei Song, Teng Liu, Peng Chen, Lei Zhou, Xinna Ge, Xin Guo, Jun Han*, Hanchun Yang. 2019. Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus. PLOS Pathogens. Nov 18. 15(11):e1008169.

  • Shao Chuanzhou, Xinna Ge, Can Kong, Lei Zhou, Xin Guo, Jun Han*, Hanchun Yang. 2019. Characterization of the PRRSV nsp2 deubiquitinase reveals dispensability of cis-activity for replication and a strong link of nsp2 to inflammation induction. Viruses. 11(10), 896.

  • Jiangwei Song, Peng Gao, Yunhao Hu, Yue Chai, Lei Zhou, Xinna Ge, Xin Guo, Jun Han*, Hanchun Yang. 2019. The nsp2 replicase protein of porcine reproductive and respiratory syndrome virus is associated with tissue tropism to primary porcine alveolar macrophages. Journal of Virology. pii: JVI.01436-19. doi: 10.1128/JVI.01436-19.

  • Jiangwei Song, Yuanyuan Liu, Peng Gao, Yunhao Hu, Yue Chai, Shaochuan Zhou, Can Kong, Lei Zhou, Xinna Ge, Xin Guo, Jun Han*, Hanchun Yang. 2018. Mapping the nonstructural protein interaction network of porcine reproductive and respiratory syndrome virus. Journal of Virology. Pii: JVI.01112-18. (JVI spotlight article)

  • Jillian Carmichael, Jason Starkey, Dan Zhang, Akua Sarfo, Pooja Chadha, John W Wills, and Jun Han*. 2018. Glycoprotein D of HSV-1 is dependent on tegument protein UL16 for packaging and contains a motif that is differentially required for syncytia formation. Virology. 527: 64-76.

  • Di Wang, Xinna Ge, Dongjie Chen, Jie Li, Yueqi Cai, Jin Deng, Lei Zhou, Xin Guo, Jun Han*, Hanchun Yang*. 2018. The S Gene Is Necessary but Not Sufficient for the Virulence of Porcine Epidemic Diarrhea Virus Novel Variant Strain BJ2011C. Journal of Virology. 92 (13): e00603-18.

  • Yuanyuan Liu, Yuhao Hu, Yue Chai, Liping Liu, Jiangwei Song, Shaochuan Zhou, Jia Su, Lei Zhou, Xinna Ge, Xin Guo, Jun Han* and Hanchun Yang*. 2018. Identification of Nonstructural Protein 8 as the N-Terminus of the RNA-Dependent RNA Polymerase of Porcine Reproductive and Respiratory Syndrome Virus. Virol Sin. 3(5):429-439.

  • Jie Li，Zhonghui Jin，Yueyi Gao，Lei Zhou，Xinna Ge，Xin Guo，Jun Han* and Hanchun Yang*. 2017. Development of the full-length cDNA clones of two porcine epidemic diarrhea disease virus isolates with different virulence. PLos One.  Mar 16;12(3):e0173998. doi: 10.1371/journal.pone.0173998.

  • Jun Han#, Lei Zhou#, Xinna Ge, Xin Guo and Hanchun Yang. 2017. Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus. Veterinary Microbiology. pii: S0378-1135(16) 30512-0. doi: 10.1016/j.vetmic.2017.02.0202017.03.02

  • Jige Du., Xinna Ge, Ying Liu，Ping Jiang, Zhe Wang, Ruimin Zhang, Lei  Zhou, Xin Guo, Jun Han* and Hanchun Yang*. 2016. Targeting Swine Leukocyte Antigen Class I Molecules for Proteasomal Degradation by the nsp1α Replicase Protein of the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Strain JXwn06. Journal of Virology. 90(2):682-693.

  • Jun Han, Pooja Chadha, Jason L. Starkey and John Wills. 2012. Function of glycoprotein E of herpes simplex virus requires coordinated assembly of three tegument proteins on its cytoplasmic tail. Proc Natl Acad Sci USA. 109 (48): 19798-803.

  • Pei-Jun Yeh#, Jun Han#, Pooja Chadha#, David G. Meckes, Jr., Michael D. Ward, O. John Semmes, and John W. Wills. 2011. Direct and Specific Binding of the UL16 Tegument Protein of Herpes Simplex Virus to the Cytoplasmic Tail of Glycoprotein E. Journal of Virology. 85: 9425-36.

  • Jun Han, Pooja Chadha, David Meckes. Jr., Nicholas Baird, and John W. Wills. 2011. Interaction and Inter-Dependent Packaging of the Herpes Simplex Virus Tegument Protein UL11 and Glycoprotein E. Journal of Virology. 85: 9437-46.

  • Jun Han, Mark S. Rutherford, and Kay S. Faaberg. 2010. Proteolytic Products of the Porcine Reproductive and Respiratory Syndrome Virus Nsp2 Replicase Protein. Journal of Virology. 84: 10102-12.

  • Jun Han, Mark S. Rutherford, and Kay S. Faaberg. 2009. Porcine Reproductive and Respiratory Syndrome Virus Nsp2 Cysteine Protease Domain Possesses Both Trans and Cis-cleavage activities. Journal of Virology. 83: 9449-63

  • Jun Han, Gongping Liu, Yue Wang, and Kay S. Faaberg. 2007. Identification of Nonessential Regions in the Nsp2 Replicase Protein of Porcine Reproductive and Respiratory Syndrome Virus for Replication in Cell Culture. Journal of Virology. 81: 9878-90.

  • Jun Han, Yue Wang, and Kay S. Faaberg. 2006. Complete Genome Analysis of RFLP 184 Isolates of Porcine Reproductive and Respiratory Syndrome Virus. Virus Research. 122:175-82.