个人简介: 朱奎 中国农业大学领军教授、博士生导师。德国墨卡托学者(Mercator Fellow,2021)、国家优秀青年科学基金获得者(2019)、北京市优秀青年人才(2020)、入选北京青年人才托举工程(2019)、北京食品营养与健康高精尖创新中心岗位科学家(2016),美国杜克大学博士后、德国慕尼黑大学博士。目前担任Microbial Cell、Frontiers in Microbiology等期刊编委,中国工程院院刊Engineering客座编辑,中国畜牧兽医学会兽医药理与毒理学分会常务理事、中国微生物学会兽医微生物学专业委员会常务委员(青年组)、中国化学会会员等。主要围绕兽医公共卫生领域耐药病原菌控制的核心问题开展科学研究,通过发现抗菌新靶点,研发新型抗菌药物,提高宿主导向的抗菌药物疗效,开发益生菌类抗菌替代物,保障人类健康和动物源性食品安全。近5年来正主持“十三五”国家重点研发计划课题、国家自然科学基金等项目多项,相关研究成果在以通讯作者(含并列)在Nature Microbiology、Advanced Science、Lancet Infectious Diseases、Natural Product Reports、Angewandte Chemie、PLoS Pathogen、科学通报和微生物学报等国内外顶级学术期刊以封面文章等形式发表论文40余篇;申请专利5项,授权4项,为我国耐药性病原菌防控和新型抗菌药物创制提供了理论依据和技术支持。 代表性文章 (更新至2021.6): 1, Liu X#, Wu Y#, Mao C, Shen J, Zhu K*. Host-acting antibacterial drugs combat internalized bacteria, Trends in Microbiology, (Invited, in preparation, IF=13.537) 2, Song M#, Liu Y#, Li T#, Liu X, Hao Z, Ding S, Panichayupakaranant P, Zhu K*, Shen J*. Plant natural flavonoids against multidrug resistant pathogens, Advanced Science, 2021, 8, 2100749. (IF=15.627) 3, Wu Y#, Wang Y#, Yang H, Li Q, Gong X, Zhang G*, Zhu K*. Resident bacteria contribute to the opportunistic infection of the respiratory tract. PLoS Pathogens, 2021, 17, e1009436. (IF=6.218) 4, Li Y#, Liu F#, Zhang J, Liu X, Xiao P, Bai H, Chen S, Wang D, Sung SHP, Kwok RTK, Shen J, Zhu K*, Tang BZ*. Efficient killing of multidrug-resistant internalized bacteria by AIEgens in vivo. Advanced Science, 2021, 8, 2001750. (Back cover, IF=15.627) 5, Chen S, Liu D, Zhang Q, Guo P, Ding S, Shen J, Zhu K*, Lin W*. A marine antibiotic kills multidrug-resistant bacteria without high-level resistance development. ACS Infectious Diseases, 2021, 7, 884-893. (Cover, IF=4.970) 6, Liu X#, Liu F#, Ding S, Shen J*, Zhu K*. Sublethal levels of antibiotics promote bacterial persistence in epithelial cells. Advanced Science, 2020, 7, 1900840. (Back cover, IF=15.627) 7, Song M#, Liu Y#, Huang X, Chen S, Liu F, Ding S, Wang Y, Shen J*, Zhu K*. A broad-spectrum antibiotic adjuvant reverses multidrug resistant Gram-negative pathogens. Nature Microbiology, 2020, 5, 1040-1050. (IF=16.293) 8, Liu Y, Jia Y, Yang K, Li R, Xiao X, Zhu K*, Wang Z*. Metformin restores tetracyclines susceptibility against multi-drug resistant bacteria. Advanced Science, 2020, 7: 1902227. (IF=15.627) 9, Cui Y#, Wang S#, Ding S, Shao B, Shen J, Zhu K*. Toxins and mobile antimicrobial resistance genes in Bacillus probiotics constitute a potential risk for one health. Journal of Hazardous Materials, 2020, 382: 121266. (IF=8.512) 10, Qu S, Liu Y, Hu Q, Han Y, Hao Z, Shen J*, Zhu K*. Programmable antibiotic delivery to combat methicillin-resistant Staphylococcus aureus through precision therapy. Journal of Controlled Release, 2020, 321: 710-717. (IF=8.626) 11, Zhu K, Chen S, Sysoeva T, You L*. Universal antibiotic tolerance arising from antibiotic-triggered accumulation of pyocyanin in Pseudomonas aeruginosa. PLoS Biology, 2019, 17: e3000573. (IF=8.878) 12, Liu Y, Ding S, Shen J, Zhu K*. Nonribosomal antibacterial peptides that target multidrug-resistant bacteria, Natural Product Reports, 2019, 36, 573-592. (Cover, IF=11.666) 13, Xie Y, Liu Y, Yang J, Liu Y, Hu F*, Zhu K*, Jiang X*, Gold nanoclusters for targeting methicillin-resistant Staphylococcus aureus in vivo. Angewandte Chemie International Edition, 2018, 57:3958-3962. (IF=12.659) 14, Yang Z, Huang Y, Zhou H, Zhang R, Zhu K*, Persistent carbapenem-resistant Klebsiella pneumoniae: a Trojan horse. The Lancet Infectious Diseases, 2018, 18: 22-23. (IF=22.945) 15, Liu Y, Ding S, Dietrich R, Märtlbauer E, Zhu K*. A biosurfactant inspired heptapeptide with improved specificity to kill MRSA. Angewandte Chemie International Edition, 2017, 56:1486-1490. (Frontispiece, IF=12.659)
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