姓名：张大丙
性别：男
职称：教授
学位：硕士
所在系：预防兽医系
导师类型：博导兼硕导
出生年月：1965.12
电子邮件：zdb@cau.edu.cn
办公电话：62733348
个人简介
国家水禽产业技术体系疾病防控研究室主任、生物安全与综合防控岗位专家，国家水禽遗传改良计划专家组成员，中国畜牧兽医学会禽病学分会第10届理事会副理事长，中国畜牧业协会白羽肉鸭工作委员会和鹅业工作委员会专家委员会委员。
工作经历
1988年至今，在动医工作。
研究领域
水禽主要疫病病原学、分子流行病学、诊断与防控技术、致病机理和免疫保护机制
获奖及荣誉
上海市科学技术奖二等奖1项
浙江省科学技术进步奖三等奖1项
山东省科技进步一等奖
教学工作
本科生《兽医生物制品学》，硕士生《畜禽疫病防治实践》
在研项目
现代农业产业技术体系-水禽，国家自然科学基金面上项目坦布苏病毒毒力相关分子基础研究
代表性文章
[1]Yang L, Liang T, Lv J, Qu S, Meng R, Yang B, Feng C, Dai W, Wang X, Zhang B, Zhang D. Substantial Attenuation of Virulence of Tembusu Virus Strain PS Is Determined by an Arginine at Residue 304 of the Envelope Protein. J Virol, 2021, 95(6):e02331-20.
[2]Feng C, Jin M, Yang L, Lv J, Qu S, Meng R, Yang B, Wang X, Zhang D. Pathogenicity of a Jinding duck-origin cluster 2.1 isolate of Tembusu virus in 3-week-old Pekin ducklings. Vet Microbiol, 2020, 251:108870.
[3]Lv J, Liu X, Cui S, Yang L, Qu S, Meng R, Yang B, Feng C, Wang X, Zhang D. The Neutralizing Antibody Response Elicited by Tembusu Virus Is Affected Dramatically by a Single Mutation in the Stem Region of the Envelope Protein. Front Microbiol, 2020, 11:585194.
[4]Liang S, Tang J, Wang X, Wen Z, Xie M, Wu Y, Hou S, Zhang D. Effect of duck hepatitis A virus genotype 3 infection on glucose metabolism of Pekin ducklings and underlying mechanism. Gene, 2020, 748:144710.
[5]Qu S, Wang X, Yang L, Lv J, Meng R, Dai W, Li Q, Liu H, Zhang B, Zhang D. Identification of a Neutralizing Monoclonal Antibody That Recognizes a Unique Epitope on Domain III of the Envelope Protein of Tembusu Virus. Viruses, 2020,12(6):647.
[6]Wang M, Chai L, Liang S, Lv J, Yang L, Qu S, Jin M, Li Q, Wang X, Zhang D. Fetal Calf Serum Exerts an Inhibitory Effect on Replication of Duck Hepatitis A Virus Genotype 1 in Duck Embryo Fibroblast Cells. Viruses, 2020,12(1):80.
[7]Jin M, Feng C, Wang X, Zhang D. Molecular evidence of goose-parvovirus-related abnormal molting in Pekin ducks. Arch Virol, 2019,164(11):2837-2841.
[8]Lv J, Yang L, Qu S, Meng R, Li Q, Liu H, Wang X, Zhang D. Detection of Neutralizing Antibodies to Tembusu Virus: Implications for Infection and Immunity. Front Vet Sci, 2019, 6:442.
[9]Liang T, Liu X, Qu S, Lv J, Yang L, Zhang D. Pathogenicity of egg-type duck-origin isolate of Tembusu virus in Pekin ducklings. BMC Vet Res, 2019,15(1):362.
[10]Chu L, Jin M, Feng C, Wang X, Zhang D. A highly divergent hepacivirus-like flavivirus in domestic ducks. J Gen Virol, 2019, 100(8):1234-1240.
[11]Wang M, Li Z, Liu H, Wang X, Zhang D. Effect of fetal calf serum on propagation of duck hepatitis A virus genotype 3 in duck embryo fibroblast cells. BMC Vet Res. 2019, 15(1):153.
[12]Ning K, Liang T, Wang M, Dong Y, Qu S, Zhang D. Pathogenicity of a variant goose parvovirus, from short beak and dwarfism syndrome of Pekin ducks, in goose embryos and goslings. Avian Pathol, 2018, 47(4):391-399.
[13]Liu N, Jiang M, Dong Y, Wang X, Zhang D. Genetic characterization of a novel group of avastroviruses in geese. Transbound Emerg Dis, 2018, 65(4):927-932.
[14]Jin M, Wang X, Ning K, Liu N, Zhang D. Genetic characterization of a new astrovirus in goslings suffering from gout. Arch Virol, 2018, 163(10):2865-2869.
