目前主要从事药理基因组, 毒理基因组，微生物相关宏基因组和生物信息学方面的研究；发表SCI论文70余篇，主要研究成果论文引用1500次以上，第一作者及通讯作者文章20余篇，受邀在国际动植物基因组会议(PAG)上做学术报告4次，目前担任Frontiers in Microbiology和Frontiers in Livestock Genomics等杂志编委；参与出版著作3章节，主持国家重点研发计划课题1项，共主持参与项自然科学基金5项，2018年获得北京市科技新星。

学习经历

博士  2004-2009 美国奥本大学农学院分子生物学

本科  1999-2003 中国农业大学生物学院

工作经历

2015-至今 中国农业大学动物医学院  副教授

2010-2014 弗吉尼亚大学医学院神经遗传学和药理基因组学实验室 研究员

2009-2010 奥本大学水产系鱼类分子生物学实验室  助理研究员

研究生课程

兽医基因组学和生物信息学（课程编码74055716）

生物信息学的概念和发展历史、生物信息学的基础；分子生物学数据库，包括生物学数据库，核苷酸序列与基因组数据库，蛋白质序列与模式等，及数据库中存在的问题及使用注意事项；序列比对与数据库检索，包括序列比对，比对的统计学显著性，数据库搜索；核酸序列的信号和功能识别，包括DNA序列的统计学与信息学分析，核酸和蛋白质序列的进化分析；基因组测序与分析，包括DNA 测序与序列片段的拼接，编码蛋白质基因区域的预测，基因组的比较；功能基因组信息学，包括功能基因组信息学及基因表达数据分析等。

负责主持和参与研究项目

2016-2019 科技部：国家重点研发计划-畜禽重要病原耐药性检测与控制技术研究，畜禽病原菌耐药性检测技术研究（批准号：2016YFD0501301，520万）主持

2016-2019 中国国家自然科学基金：通过宏基因组研究猪场养殖环境中的β-内酰胺酶基因流行和传播机制 （批准号：NSF31572568，76万）主持

2016-2019 中国国家自然科学基金：鸡源碳青霉烯类抗生素耐药大肠杆菌的产生机制和适应性研究 （批准号：NSF31530076，328万）参与

中国国家自然科学基金：泛耐药肠杆菌细菌在动物、食品/环境、人之间的传播及其影响研究 （批准号：NSF81661138002，252万）参与

代表性文章

Wang X, Wang Y, Wang Y, Zhang S, Shen Z, Wang S*. Emergence of the colistin resistance gene mcr-1 and its variant in several uncommon species of Enterobacteriaceae from commercial poultry farm surrounding environments. Vet Microbiol. 2018 Jun;219:161-164. doi: 10.1016/j.vetmic.2018.04.002. Epub 2018 Apr 14.

Wu C, Wang Y, Shi X, Wang S, Ren H, Shen Z, Wang Y, Lin J, Wang S*. Rapid rise of the ESBL and mcr-1 genes in Escherichia coli of chicken origin in China, 2008-2014. Emerg Microbes Infect. 2018 Mar 14;7(1):30.

Li Y, Sun QL, Shen Y, Zhang Y, Yang JW, Shu LB, Zhou HW, Wang Y, Wang B, Zhang R, Wang S, Shen Z. Rapid Increase in Prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) and Emergence of Colistin Resistance Gene mcr-1 in CRE in a Hospital in Henan, China. J Clin Microbiol. 2018 Mar 26;56(4). pii:e01932-17.

Yang Q, Li M, Spiller OB, Andrey DO, Hinchliffe P, Li H, MacLean C, Niumsup P, Powell L, Pritchard M, Papkou A, Shen Y, Portal E, Sands K, Spencer J, Tansawai U, Thomas D, Wang S, Wang Y, Shen J, Walsh T. Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms. Nat Commun. 2017 Dec 12;8(1):2054.

Wang X, Zhai W, Li J, Liu D, Zhang Q, Shen Z, Wang S*, Wang Y. Presence of mcr-3 variant in Aeromonas caviae, Proteus mirabilis, and Escherichia coli from one domestic duck. Antimicrob Agents Chemother. 2017 Dec 4. pii: AAC.02106-17.

Li J, Shi X, Yin W, Wang Y, Shen Z, Ding S, Wang S*. A Multiplex SYBR Green Real-Time PCR Assay for the Detection of Three Colistin Resistance Genes from Cultured Bacteria, Feces, and Environment Samples. Front Microbiol. 2017 Oct 27;8:2078.

Yin W, Li H, Shen Y, Liu Z, Wang S, Shen Z, Zhang R, Walsh TR, Shen J, Wang Y. Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli. MBio. 2017 Jun 27;8(3). pii: e00543-17.

Zhang R, Liu Z, Li J, Lei L, Yin W, Li M, Wu C, Walsh TR, Wang Y, Wang S*, Wu Y. Presence of VIM-Positive Pseudomonas Species in Chickens and Their Surrounding Environment. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00167-17.

Wang Y, Tian GB, Zhang R, Shen Y, Tyrrell JM, Huang X, Zhou H, Lei L, Li HY, Doi Y, Fang Y, Ren H, Zhong LL, Shen Z, Zeng KJ, Wang S, Liu JH, Wu C, Walsh TR, Shen J. Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1-positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study. Lancet Infect Dis. 2017 Apr;17(4):390-399.

Wang Y, Zhang R, Li J, Wu Z, Yin W, Schwarz S, Tyrrell JM, Zheng Y, Wang S, Shen Z, Liu Z, Liu J, Lei L, Li M, Zhang Q, Wu C, Zhang Q, Wu Y, Walsh TR, Shen J. Comprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry production. Nat Microbiol. 2017 Feb 6;2:16260.

Yao H, Shen Z, Wang Y, Deng F, Liu D, Naren G, Dai L, Su CC, Wang B, Wang S, Wu C, Yu EW, Zhang Q, Shen J. Emergence of a Potent Multidrug Efflux Pump Variant That Enhances Campylobacter Resistance to Multiple Antibiotics. MBio. 2016 Sep 20;7(5). pii: e01543-16.

Zhou B, Wang C, Zhao Q, Wang Y, Huo M, Wang J, Wang S* (2016) Prevalence and dissemination of antibiotic resistance genes and coselection of heavy metals in Chinese dairy farms. J Hazard Mater. 2016 Aug 4;320:10-17.

Huo M, Han H, Sun Z, Lu Z, Yao X, Wang S*, Wang J. (2016) Role of IL-17 Pathways in Immune Privilege: A RNA Deep Sequencing Analysis of the Mice Testis Exposure to Fluoride. Sci Rep. 2016 Aug 30;6:32173.

Zhao Q, Wang Y, Wang S, Wang Z, Du XD, Jiang H, Xia X, Shen Z, Ding S, Wu C, Zhou B, Wu Y, Shen J. (2016) Prevalence and Abundance of Florfenicol and Linezolid Resistance Genes in Soils Adjacent to Swine Feedlots. Sci Rep. 2016 Aug 30;6:32192.

Cao J, Nesil T, Wang S, Chang SL, Li MD. (2016) Expression profile of nicotinic acetylcholine receptor subunits in the brain of HIV-1 transgenic rats given chronic nicotine treatment. J Neurovirol. 2016 Oct;22(5):626-633.

Yang J,  Wang S, Yang ZL, Hodgkinson CA, Iarikova P, Ma JZ, Payne TJ, Goldman D, Li MD. (2014) The Contribution of Rare and Common Variants in 30 Genes to Risk Nicotine Dependence. Mol Psychiatry. 2015 Nov;20(11):1467-78.

Cui WY, Wang S, Yang J, Yi SG, Yoon D, Kim YJ, Payne TJ, Ma JZ, Park T, Li MD. (2013) Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations. Mol Psychiatry. 2013 Nov;18(11):1149-51. (IF=15.147)

Xu P, Zhang X, Wang X, Li J, Liu G, Kuang Y, Xu J, Zheng X, Ren L, Wang G, Zhang Y, Huo L, Zhao Z, Cao D, Lu C, Li C, Zhou Y, Liu Z, Fan Z, Shan G, Li X, Wu S, Song L, Hou G, Jiang Y, Jeney Z, Yu D, Wang L, Shao C, Song L, Sun J, Ji P, Wang J, Li Q, Xu L, Sun F, Feng J, Wang C, Wang S, Wang B, Li Y, Zhu Y, Xue W, Zhao L, Wang J, Gu Y, Lv W, Wu K, Xiao J, Wu J, Zhang Z, Yu J, Sun X. Genome sequence and genetic diversity of the common carp, Cyprinus carpio. Nat Genet.

2014 Nov;46(11):1212-9. (IF=29.648)

Wang S, Abernathy J, Waldbieser G, Lindquist E, Richardson, Liu Z and the Catfish Genome Consortium (2010) Assembly of 500,000 inter-specific catfish expressed sequence tags and large scale gene-associated marker development for whole genome association studies. Genome Biology 22; 11(1):R8. (IF=10.5)

Lu J, Peatman E, Yang Q, Wang S, Hu Z, Reecy J, Kucuktas H, Liu Z (2011) The catfish genome database cBARBEL: an informatic platform for genome biology of ictalurid catfish. Nucleic Acids Research 2011 Jan;39:D815-21 (IF=8.808)

Wang S, Yang Z, Ma JZ, Payne TJ, Li MD. (2014) Introduction to Deep Sequencing and Its Application to Drug Addiction Research with a Focus on Rare Variants. Mol Neurobiol. 2014 Feb;49(1):601-14. (IF=5.286)

Liu Y, Wang Y, Schwarz S, Wang S, Chen L, Wu C, Shen JZ. (2014) Investigation of a multi-resistance gene cfr that fails to mediate resistance to phenicols and oxazolidinones in Enterococcus faecalis. J Antimicrob Chemother. 2014 Apr; 69(4):892-8. (IF=5.439)

Lu Z, Wang S, Sun Z, Niu R, Wang J. (2014) In vivo influence of sodium fluoride onsperm chemotaxis in male mice. Arch Toxicol. 2014 Feb;88(2):533-9. (IF=5.078)

Wang S, van der Vaart A, Seneviratne C, Xu Q, Pomerleau OF, Pomerleau CS, Payne TJ, Ma JZ, Li MD. (2014) Significant Associations of CHRNA2 and CHRNA6 with Nicotine Dependence in European-American and African-American Populations. Human Genetics. 2014 May;133(5):575-86. (IF=4.633)

Luo GY, Wang S, Li ZG, Wang JD. (2014) Maternal BisphenolA Diet Induces Anxiety-like Behavior in Female Adolescents with Neuroimmune Activation. Toxical Science, in press (IF=4.478)

Wang S, Liu H, Wang Y, Kucuktas H, Bushek D, Wang L, Shi Y, Quilang J, Li P, Wallace R, Guo X, Liu Z (2010) Microarray analysis of gene expression in eastern Oyster (Crassostrea virginica) reveals oxidative stress and apoptosis host responses after dermo (Perkinsus marinus) challenge. Fish & Shellfish Immunology 2010 Dec;29(6):921-9 (IF=3.034)

Cao J, Wang S, Wang J, Cui W, Nesil T, Vigorito M, Chang SL, Li MD. (2013) RNA Deep Sequencing Analysis Reveals that Nicotine Restores Impaired Gene Expression by Viral Proteins in the Brains of HIV-1 Transgenic Rats. PloS One 2013 Jul 16;8(7):e68517. (IF=3.534，)

Li MD, Cao J, Wang S, Wang J, Sarkar S, Vigorito M, and Chang SL (2013) Transcriptome sequencing analysis of gene expression in the brains of HIV-1 transgenic rats. Plos One 2013;8(3):e59582 (IF=3.534)

Li EC, Wang S, Li C, Wang XD, Chen K, Chen LQ. (2014) Transcriptome Sequencing Revealed the Genes and Pathways Involved in Salinity Stress of Chinese Mitten Crab, Eriocheir sinensis. Physiological Genome 2014 Mar 1; 46(5):177-90. (IF=2.812)

*通讯作者