周磊， 男， 中国农业大学动物医学院教授/博士生导师，中国农业大学畜禽疫病诊断研究中心副主任。主要从事猪病毒性传染病研究，研究方向集中于猪繁殖与呼吸综合征病毒（PRRSV）病原学、分子流行病学、感染与免疫、致病机制和新型疫苗创制等方面。结合猪场临床生产，熟悉PRRSV、ASF和PEDV等重要病原的诊断和防控措施。在 PNAS、Cell Mol Life Sci、PLOS Pathogens、Emerging Infectious Diseases和Journal of Virology 等国外权威期刊发表SCI论文近 50篇。其中EID文章入选全球兽医学文章最高引用率top100目录。现为生猪产业体系疫病控制室研究人员、畜牧兽医学会养猪学分会副秘书长，中国动物疫控制中心疫病净化评估专家，《中国兽医杂志》和国外期刊《Intervirology》副主编,《One Health Advances 》科学编辑，《Virus Research》 编委。并开设有猪兽医科普公众号VETMOOC。

博士毕业后受国外知名药企研究项目资助赴美国佛吉尼亚理工大学从事博士后研究，导师为美国科学院院士Xiang-jin Meng教授。期间利用DNA shuffling技术和动物感染模型开发具异源保护性的新型广谱PRRS疫苗，其成果（本人为发明人之一）进入PPA程序（美国专利申请号61/700,912）。

主持“高等学校全国优秀博士学位论文作者专项资金资助项目”， 国家自然科学基金青年项目/面上项目”,十三五/ 十四五重点研发项目子课题，“大北农青年学者研究计划”，以及多项“企业横向合作项目“。参加973研究项目，国家自然科学基金重大和国家自然科学基金重点等多项PRRSV相关的基础研究项目。曾任2016年International PRRS Symposium学术委员会成员，第25 届国际猪病大会学术委员会秘书，并作为欧盟PRRSCon项目和美国NC229项目联系人之一，负责团队国际合作事宜。

承担《养殖场生物安全》、《兽医微生物学》《动物传染病学》《畜禽疫病防治》和《预防兽医学专业seminar》的教学工作。所撰写案例《猪繁殖与呼吸综合征》于2017年入选中国专业学位案例中心兽医专业学位案例库。

2005-2010  博士，中国农业大学动物医学院，预防兽医学系，动物分子病毒学与免疫学方向

2000-2005  本科，中国农业大学动物医学院，动物医学专业

2024-至今，中国农业大学动物医学院预防兽医系，教授

2020-2023，中国农业大学动物医学院预防兽医系，副教授/博士生导师

2015-2019，中国农业大学动物医学院预防兽医系，副教授/硕士生导师

2010-2014，中国农业大学动物医学院预防兽医系，讲师

2011-2013，美国弗吉尼亚理工大学兽医学院生物医学与病理系，博士后

2005-2010，农业部动物分子流行病学与人兽共患病重点实验室，研究助理

      猪繁殖与呼吸综合征病毒（PRRSV）的病原学、分子流行病学、感染与免疫、致病机制和新型疫苗创制研究

学术兼职：

-中国畜牧兽医学会养猪学分会副秘书长

-中国动物疫控制中心疫病净化评估专家

-《中国兽医杂志》副主编

- Intervirology, Associate Editor 

-Virus Research, Editor

- One Health Advances, Science Editor

2023年 首届兽医专业学位研究生创新创业大赛一等奖（冠军）指导教师

2023年 中国农业大学动物医学院2023届本科生“优秀毕业论文“指导教师奖

2021年 北京市普通高校优秀本科毕业设计（论文）优秀指导教师

2017年 中国农业大学2017届本科生“百篇优秀毕业论文（设计）优秀指导教师奖

2016年 大北农优秀青年研究者奖

2016年 勃林格殷格翰年度PRRS研究进展奖

2012年 全国百篇优秀博士论文奖

2011年 北京市优秀博士论文奖

2010年 中国农业大学十佳优秀博士论文奖

2010年 勃林格殷格翰动物医学院优秀毕业生奖学金

2010年 2010年度博士生科研成就奖

-《兽医微生物学》和《兽医微生物学实验》（本科生）

-《养殖场生物安全》、《动物传染病学》、《畜禽疫病防治》（硕士研究生）

- 《预防兽医学专业Seminar》(预防兽医系博士研究生)

1. Sun Weifeng, Wu Weixin, Fang Xinyu, Ge Xinna, Zhang Yongning, Han Jun, Guo Xin, Zhou Lei* ^co, Yang Hanchun* ^co. Disruption of pulmonary microvascular endothelial barrier by dysregulated claudin-8 and claudin-4: uncovered mechanisms in porcine reproductive and respiratory syndrome virus infection. Cell Mol Life Sci. 2024 May 28;81(1):240.

2. Gao, Xiang, Bian Ting, Gao Peng, Ge Xinna, Zhang Yongning, Han Jun, Guo Xin, Zhou Lei* ^co, Yang Hanchun* ^co. 2024. Fidelity Characterization of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and NADC30-like Strain. Viruses 16, no. 5: 797.

3. Gao Peng^co, Zhou Lei^co, Wu Jiajun^co, Weng Wenlian, Wang Hua, Ye Miaomiao, Qu Yajin, Hao Yuxin, Zhang Yongning, Ge Xinna, Guo Xin, Han Jun, and Yang Hanchun. Riding apoptotic bodies for cell–cell transmission by African swine fever virus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2023, Vol. 120 | No. 48, November 28.

4. Cao Xiaoyu, Ge Xinna, Zhang Yongning, Guo Xin, Han Jun, Zhou Lei* ^co, Yang Hanchun* ^co. Genetic Characteristics of Three Single-Farm-Isolated Porcine Reproductive and Respiratory Syndrome Viruses with Novel Recombination among NADC30-Like, JXA1-Like, and QYYZ-Like Strains. Transboundary and Emerging Diseases, vol. 2023, Article ID 8871321.

5. Xingzhen Tang, Cong Wang, Weifeng Sun, Weixin Wu, Shaohui Sun, Jin Wan, Guangshan Zhu, Nini Ma, Xiaoping Ma, Ruihua Xu, Qiushi Yang, Yindi Dai, Lei Zhou. Evaluating anti-viral effect of Tylvalosin tartrate on porcine reproductive and respiratory syndrome virus and analyzing the related gene regulation by transcriptomics. Virol J. 2023 Apr 26;20(1):79.

6. Tan, Shaoyuan , Wu, Weixin, Ge, Xinna, Zhang, Yongning, Han, Jun, Guo, Xin, Zhou Lei* ^co, Yang Hanchun* ^co. A novel strategy to attenuate porcine reproductive and respiratory syndrome virus by inhibiting viral replication in the target pulmonary alveolar macrophages via hematopoietic-specific miR-142. One Health Advances, 2023.Apirl 1(1), 3.

7. Wang Jingjing, Zhang Mengsi, Cui Xiaocun, Gao Xiang, Sun Weifeng, Ge Xinna, Zhang Yongning, Guo Xin, Han Jun, Zhou Lei* ^co, Yang Hanchun* ^co. Attenuated Porcine Reproductive and Respiratory Syndrome Virus Regains Its Fatal Virulence by Serial Passaging in Pigs or Porcine Alveolar Macrophages To Increase Its Adaptation to Target Cells. Microbiol Spectr. 2022 Oct 11:e0308422. doi: 10.1128/spectrum.03084-22.

8. Wang Yang, Ge Xinna; Zhang Yongning, Han Jun, Guo Xin, Zhou Lei* , Yang Hanchun. Construction of a Porcine Reproductive and Respiratory Syndrome Virus with Nanoluc Luciferase Reporter: a Stable and Highly Efficient Tool for Viral Quantification Both In Vitro and In Vivo. Microbiol Spectr. 2022 Aug 31;10(4):e0027622.  

9. Sun Weifeng, Wu Weixin, Jiang Nan, Ge Xinna,  Zhang Yongning, Han Jun, Guo Xin* ^co, Zhou Lei* ^co, Yang Hanchun. Highly Pathogenic PRRSV-Infected Alveolar Macrophages Impair the Function of Pulmonary Microvascular Endothelial Cells. Viruses 2022, 14, 452.

10. Wu Weixin, Ge Xinna; Zhang Yongning, Han Jun, Guo Xin, Zhou Lei* ^co, Yang Hanchun* ^co. Evolutionary Patterns of Codon Usage in Major Lineages of Porcine Reproductive and Respiratory Syndrome Virus in China, Viruses. 2021. 13, no. 6: 1044.

11. Zhou Lei, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety. Vaccines. 2021;9:362.

12. Zhou X, Ge X, Zhang Y, Han J, Guo X, Chen Y, Zhou Lei* ^co，Yang H* ^co. Attenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model. Virulence. 2021;12:1011-21.

13. Zhou, X^co, Zhou Lei^co, Zhang, P, Guo, X., Han, J. and Yang, H. A strain of porcine deltacoronavirus: Genomic characterization, pathogenicity and its full‐length cDNA infectious clone. Transbound Emerg Dis. 2020; 00: 1-17. https://doi.org/10.1111/tbed.13862

14. Su, J., Zhang, X., He, B., Ge, X., Han, J., Zhou Lei* ^co, Guo, X* ^co. and Yang, H., Identification of three site mutations in nonstructural protein 1β, glycoprotein 3 and glycoprotein 5 that correlate with increased interferon α resistance of porcine reproductive and respiratory syndrome virus. Veterinary Microbiology, 2019. p.108395.

15. Zhang, Z^co., Zhou Lei^co ，Ge, X., Guo, X., Han, J. and Yang, H., 2018. Evolutionary analysis of six isolates of porcine reproductive and respiratory syndrome virus from a single pig farm: MLV-evolved and recombinant viruses. Infection, Genetics and Evolution, 66, pp.111-119.

16. Jiang Nan; Jin Huan; Li Yi; Ge Xinna; Han Jun; Guo Xin; Zhou Lei *; Yang Hanchun, 2017. Identification of a novel linear B-cell epitope in nonstructural protein 11 of porcine reproductive and respiratory syndrome virus that are conserved in both genotypes , PLos One, 12(11): 0~e0188946

17. Cui Zhengzhi; Niu Shuaishuai; Liu Jingjing; Xu Lei; Dai Yunping; Li Ning; Kang Youmin; Zhang Linlin *^co; Zhou Lei* ^co ; Yu Shuyang*^co ,2017. Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice , Science Bulletin, 62(24): 1634~1636

18. Gao, Xiang, Dongliang Li, Jingyi Zhao, Farong Xu, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang, and Zhou Lei*, 2016. Complete genome sequence of porcine epidemic diarrhea virus from an outbreak in a vaccinated farm in Shandong, China. Genome announcements 4, no. 4 (2016): e00619-16.

19. Zhou Lei^co, Yang Beina^co, Xu Lei., Jin, H., Ge, X., Guo, X.,  Yang, H. 2017. Efficacy evaluation of three modified-live virus vaccines against a strain of porcine reproductive and respiratory syndrome virus NADC30-like. Veterinary Microbiology.

20. Han Jun^co, Zhou Lei^co , Yang Hanchun, 2017.Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus." Veterinary Microbiology (2017).

21. Zhou Lei^co, Zichun Wang^co, Yuping Ding, Xinna Ge, Xin Guo, Hanchun Yang， 2015. NADC30-like Strain of Porcine Reproductive and Respiratory Syndrome Virus, China. Emerging infectious diseases 21.12 (2015): 2256.

22.  Li Y^co, Zhou Lei^co, Zhang JL, Ge XN, Zhou R, Zheng HG, Geng G, Guo X, Yang HC. 2014. NSP9 and NSP10 Contribute to the Fatal Virulence of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Emerging in China. PLoS pathogens. 10, e1004216.

23. Li Wang^co, Zhou Lei^co, Han Zhang, Yan Li, Xinna Ge, Xin Guo, Kangzhen Yu, Hanchun Yang,2014 Interactome Profile of the Host Cellular Proteins and the Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus. PLoS ONE 9(6): e99176. doi:10.1371/journal.pone.0099176  

24. Zhou Lei, Xiaorong Yang, Yuan Tian, Xinna Ge, Xin Guo, Hanchun Yang, 2014 Genetic Diversity Analysis of Genotype 2 Porcine Reproductive and Respiratory Syndrome Viruses Emerging in Recent Years in China. BioMed Research International, vol. 2014, Article ID 748068, 13 pages, 2014. doi:10.1155/2014/748068

25. Zhou Lei, Ni Y-Y, Piñeyro P, Cossaboom CM, Subramaniam S, Dryman, B., Huang, Y.-W., Cao, D.-J., Meng, X.-J. 2013.Broadening the Heterologous Cross-Neutralizing Antibody Inducing Ability of Porcine Reproductive and Respiratory Syndrome Virus by Breeding the GP4 or M genes. PLoS ONE 8(6): e66645. doi:10.1371/journal.pone.0066645

26. Zhou Lei, Ni, Y.-Y., Piñeyro, P., Sanford, B., Cossaboom, C., Dryman, B., Huang, Y.-W., Cao, D.-J., Meng, X.-J., 2012. DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain. Virology434, 96-109.

27. Zhou, Lei, Yang, H., 2010. Porcine reproductive and respiratory syndrome in China. Virus research154, 31-37.

28. Zhou, Lei^co, Chen, S^co., Zhang, J., Zeng, J., Guo, X., Ge, X., Zhang, D., Yang, H., 2009a. Molecular variation analysis of porcine reproductive and respiratory syndrome virus in China. Virus research145, 97-105.

29. Zhou, Lei^co, Zhang, J. ^co, Zeng, J., Yin, S., Li, Y., Zheng, L., Guo, X., Ge, X., Yang, H., 2009b. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. Journal of virology83, 5156-5167.

国际会议报告:

1. Lei Zhou, “Challenges in PRRSV Vaccine Design”. Second Research Coordination Meeting
Coordinated Research Project D3.20.37, IAEA, Vienna Austria. June 12, 2024.

2. Lei Zhou, Hanchun Yang. “Present Status of PRRSV Diversity in China”. PRRSCon Meeting, Ghent Belgium. 15-16 May,2014.

3. Lei Zhou, Xingchen Wang, Hanchun Yang. “Nsp9 and Nsp10 contribute to the pathogenicity of genotype 1 PRRSV Isolated in China” PRRSCon Meeting, Ghent Belgium. May 15-16,2014.

4. Lei Zhou, Yan-Yan Ni, Pablo Pineyro, Caitlin M. Cossaboom, Sakthivel Subramaniam, Brenton J. Sanford, Barbara A. Dryman, Yao-Wei Huang, Xiang-Jin Meng Broadening the Heterologous Cross-Neutralizing Antibody Inducing Ability of Porcine Reproductive and Respiratory Syndrome Virus by Breeding the GP4 or M genes Confference of  Reseachers Work on Animal Diseases， Chicago IL, United States. December 8-10, 2013.  

5. Lei Zhou, Xingchen Wang, Hanchun Yang. “Genomic characterization and pathogenicity of a genotype 1 PRRSV Isolated in China” PRRSCon Meeting, Loti, Italy.  November 21-22, 2013.

6. Lei Zhou, Ni, Y.-Y., Piñeyro, P., Sanford, B., Cossaboom, C., Dryman, B., Huang, Y.-W., Cao, D.-J., Meng, X.-J.. DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain. No .157. Confference of  Reseachers Work on Animal Diseases， Chicago IL, United States. December 3-4, 2012.  

7. Dan Liu, Rong Zhou, Lei Zhou*, XinGuo, XinnaGe, Hanchun Yang. The recombination between two strains of PRRSV in vivo results in the generation of recombinant virus with higher pathogenicity. P67, International PRRS Symposium, Chicago IL, United States. December 2-3, 2011.  

8. Zhou Lei, Zhang, J., Zeng, J., Yin, S., Li, Y., Zheng, L., Guo, X., Ge, X., Yang, H., 2009b. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. New generation researchers in pig viral diseases: building bridges from labs to policy and the farm, Madrid, Spain July, 2011.