长期从事兽医病理学的教学与研究工作，现任中国畜牧兽医学会兽医病理学分会第十届理事会秘书长、中国兽医协会兽医病理师分会第一届理事会副会长兼秘书长、北京实验动物学学会第十一届理事会副理事长、北京实验动物行业协会第五届理事会副理事长、北京实验动物学学会第一届实验动物兽医师专业委员会主任委员、北京实验动物学学会生物安全委员会第一届理事会副主任委员、中国畜牧兽医学会兽医病理学分会第十五届理事会理事、中国合格评定国家认可委员会（CNAS）评审员、兽医病理师（中国）、北京市实验动物专家委员会委员等。以第一作者或通讯作者在Ageing Research Reviews, Cell death＆Disease,Aging Cell，Neurobiology of Disease等SCI收录期刊发表论文53篇；获批国家发明专利6项（均为第一完成人）；以第一完成人制定北京市地方标准—实验动物病理学诊断规范；作为主编（译）出版《兽医病理学》第五版，《大鼠和小鼠病理变化术语及诊断标准的规范》《实验动物病理学—啮齿类动物和兔》，《动物疾病组织病理学诊断图谱》等。

1998.9 – 2002.7 山西农业大学 动物医学院（学士）

2002.9 – 2005.7 山西农业大学 动物医学院（硕士）

2005.9 – 2008.6 中国农业大学 动物医学院（博士）

2008.06-2010.05   中国农业大学生物学院    博士后

2010.05-2012.12   中国农业大学动物医学院  讲  师

2012.12-2019.12   中国农业大学动物医学院  副教授

2019.12-至今         中国农业大学动物医学院  教  授

动物神经退行性疾病致病机制及诊断技术研究

1. 国家自然科学基金，Retromer-VPS35在Prion疾病引起神经元线粒体动力学失衡中的调控机制，2020.1-2023.12. 

2. 国家自然科学基金，Prion疾病中PINK1-Parkin介导神经元线粒体自噬受损及PINK1失稳机制的研究，2023.1-2026.12. 

3. 国家重点研发计划，重大外来动物疫病阻断与防控技术研发项目，2022.11-2025.12. 

4. 国家重点研发计划，重大动物源性病原体传入风险评估和预警技术研究，2017.1-2019.12。

5. 校级研究生教学改革项目，主编《动物疾病组织病理学诊断图谱》。

1. Pei Wen, Zhixin Sun, Fengting Gou, Jingjing Wang, Qing Fan, Deming Zhao, Lifeng Yang*. Oxidative Stress and Mitochondrial Impairment: Key Drivers in Neurodegenerative Disorders . Ageing Research Reviews, 2025 Jan 21;104: 102667. (通讯作者)

2. Pei wen, Zhixin sun, Dongming Yang, Zhiping Li, Jie Li, Mengyang Zhao, DongDong Wang, Fengting Gou, Jingjing Wang, Yuexin Dai, and Deming Zhao, Lifeng Yang*. Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases. Cell Death Dis. 2025 Feb 3;16(1):66.  (通讯作者)

3. Mengyang Zhao, Jie Li, Zhiping Li, Dongming Yang, Dongdong Wang, Zhixin Sun, Pei Wen, Fengting Gou, Yuexin Dai, Yilan Ji, Wen Li, Deming Zhao, Lifeng Yang *.SIRT1 regulates mitochondrial damage in N2a cells treated with the prion protein fragment 106–126 via PGC-1α -TFAM—mediated mitochondrial biogenesis. International Journal of Molecular Sciences. 2024 Sep 7;25(17):9707. (通讯作者)

4. Sun, Zhixin; Chen, Linlin; Lai, Mengyu; Zhang, Xixi; Li, Jie; Li, Zhiping; Yang, Dongming; Zhao, Mengyang; Wang, Dongdong; Wen, Pei; Gou, Fengting; Dai, Yuexin; Ji, Yilan; Li, Wen; Zhao, Deming ; Liu, Xianyong; Yang, Lifeng*. Histopathological observations in a coccidiosis model of Eimeria tenellab. Animal Models and Experimental Medicine. 2024 Dec;7(6):893-903 (通讯作者)

5. Dongming Yang, Jie Li, Zhiping Li, Mengyang Zhao, Dongdong Wang, Zhixin Sun, Pei Wen, Fengting Gou, Yuexin Dai, Yilan Ji, Wen Li, Lifeng Yang*, Zhao De Ming. Cardiolipin externalization mediates prion protein (PrP) peptide 106-126-associated mitophagy and mitochondrial dysfunction . Frontiers in Molecular Neuroscience, 2023 Jun 2;16:1163981.  (通讯作者)

6. Jie Li, Dongming Yang, Zhiping Li, Mengyang Zhao, Dongdong Wang, Zhixin Sun, Pei Wen, Yuexin Dai, Fengting Gou, Yilan Ji, Deming Zhao, Lifeng Yang*. PINK1/Parkin-mediated mitophagy in neurodegenerative diseases . Ageing Research Reviews. 2023 Feb;84:101817. (通讯作者) 

7. Zhiping Li, Mengyu Lai, Jie Li, Dongming Yang, Mengyang Zhao, Dongdong Wang, Zhixin Sun, Pei Wen, Fengting Gou, Yuexin Dai, Yilan Ji, Deming Zhao, Jian Qiao* and Lifeng Yang*. RAB7A GTPase is involved in mitophagosome formation and autophagosome–lysosome fusion in N2a cells treated with the prion protein fragment 106–126. Molecular Neurobiology. 2023 Mar; 60(3): 1391-1407.  （共同通讯作者）

8. Meng Yu Lai, Jie Li, Xi Xi Zhang, Wei Wu, Zhi Ping Li, Zhi Xin Sun, Meng Yang Zhao, Dong Ming Yang, Dong Dong Wang, Wen Li, De Ming Zhao, Xiang Mei Zhou*, Li Feng Yang*. SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease. Neural Regen Res. 2022 Oct;17(10):2293-2299. （共同通讯作者）

9. Jie Li , Mengyu Lai , Xixi Zhang , Zhiping Li , Dongming Yang , Mengyang Zhao , Dongdong Wang , Zhixin Sun , Sharjeel Ehsan , Wen Li , Hongli Gao , Deming Zhao , Lifeng Yang *. PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease. Cell death＆Disease. 2022 Feb 18;13(2):162. （通讯作者）

10. Xixi Zhang, Deming Zhao, Wei Wu, Syed Zahid Ali Shah, Mengyu Lai, Dongming Yang, Jie Li, Zhiling Guan, Wen Li, Hongli Gao, Huafen Zhao, Xiangmei Zhou, Lifeng Yang*. Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases. Aging-US. 2020 Jun 10;12(11): 11139-11151.（通讯作者）

11. Wei Wu, Deming Zhao, Syed Zahid Ali Shah, Xixi Zhang, Mengyu Lai, Dongming Yang, Xiaoqian Wu, Zhiling Guan, Jie Li , Huafen Zhao, Wen Li, Hongli Gao, Xiangmei Zhou, Jian Qiao*, Lifeng Yang*. OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction and neuronal apoptosis in prion diseases. Cell death＆Disease. 2019,Sep24;10 (10):710. （共同通讯作者）

12. Mengyu Lai#，Hao Yao#, Syed Zahid Ali Shah, Wei Wu, Di Wang, Ying Zhao, Lu Wang, Xiangmei Zhou, Deming Zhao, Lifeng Yang*. The NLRP3-Caspase 1 inflammasome negatively regulates autophagy via TLR4-TRIF in Prion peptide-infected microglia. Frontiers in Aging Neuroscience. 2018 Apr 18;10:116.IF:4.55 (通讯作者)

13. Chaosi Li, Di Wang, Wei Wu, Wei Yang, Syed Zahid Ali Shah,Ying Zhao, Yuhan Duan, Wang Lu, Xiangmei Zhou, Deming Zhao, Lifeng Yang*. DLP1-dependent mitochondrial fragmentation and redistribution mediate prion-associated mitochondrial dysfunction and neuronal death. Aging Cell, 2018 Feb; 17(1): e12693.（通讯作者）

14. Chunyu Wang#, Deming Zhao#, Syed Zahid Ali Shah, Wei Yang, Chaosi Li, and Lifeng Yang* . Proteome Analysis of Potential Synaptic Vesicle Cycle Biomarkers in the Cerebrospinal Fluid of Patients with Sporadic Creutzfeldt–Jakob Disease. Molecular Neurobiology. 2017 Sep;54(7):5177-5191.（通讯作者）

15. Yongyao Fu#, Deming Zhao#, Bo Pan, Jihong Wang, Yongyong Cui, Fushan Shi, Chunyu Wang, Xiaoming Yin, Xiangmei Zhou, Lifeng Yang*. Proteomic analysis of protein expression throughout disease progression in a mouse model of Alzheimer’s disease. J Alzheimers Dis. 2015 Aug 11;47(4):915-26.（通讯作者）