杨利峰,女,1980年出生,中共党员,博士,任职于中国农业大学动物医学院,教授,博导兼硕导。主要从事兽医病理学的教学与研究工作,研究方向为传染性海绵状脑病的致病机制及诊断新技术的研究。现任中国畜牧兽医学会兽医病理学分会第九届理事会副理事长兼秘书长、中国兽医协会兽医病理师分会第一届理事会副会长兼秘书长、中国药学会毒性病理学专业委员会委员、中国兽医协会标准化技术委员会委员、中国兽医协会实验动物兽医分会委员、中国兽医病理师、国家科技专家库专家、北京市科委专家等;担任《实验动物科学》期刊第七届编委、《中国比较医学杂志》第四届编委、Aging Cell、Cellular and Molecular Life Sciences、Neurobiology of Diseases、Journal of Alzheimer diseases等杂志评审。作为项目主持人,已承担国家及省部级科研课题等20余项;获批国家发明专利6项(均为第一完成人);获得教育部成果鉴定2项(第三完成人);在国内外期刊上发表学术论文150余篇,其中国际会议论文5篇,以第一作者及通讯作者在Aging Cell,Molecular Neurobiology, Ageing Research Reviews, Cellular and Molecular Life Science, Neurobiology of Disease等SCI收录期刊发表论文40余篇;主编及参编教材、著(译)作17部。 【代表性论文】 1.Xixi Zhang, Deming Zhao, Wei Wu, Syed Zahid Ali Shah, Mengyu Lai, Dongming Yang, Jie Li, Zhiling Guan, Wen Li, Hongli Gao, Huafen Zhao, Xiangmei Zhou, Lifeng Yang*. Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases. Aging-US. 2020 Jun 10;12(11): 11139-11151. IF:5.397(通讯作者) 2.Dongming Yang, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Mengyu Lai1,Xixi Zhang, Jie Li , Zhiling Guan, Huafen Zhao, Wen Li , Hongli Gao, Xiangmei Zhou, Lifeng Yang*. Implications of gut microbiota dysbiosis and metabolic changes in prion disease. Neurobiology of Diseases. 2020 Feb;135:104704. IF:5.304(通讯作者) 3.Dongming Yang, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Mengyu Lai, Xixi Zhang, Jie Li, Zhiling Guan, Huafeng Zhao, Wen Li1, Hongli Gao, Xiangmei Zhou, Lifeng Yang*. The role of gut microbiota in pathogenesis of Parkinson’s disease . Frontiers in Neurology. 2019 Nov 6;10:1155. IF:3.233(通讯作者) 4.Wei Wu, Deming Zhao, Syed Zahid Ali Shah, Xixi Zhang, Mengyu Lai, Dongming Yang, Xiaoqian Wu, Zhiling Guan, Jie Li , Huafen Zhao, Wen Li, Hongli Gao, Xiangmei Zhou, Jian Qiao*, Lifeng Yang*. OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction and neuronal apoptosis in prion diseases.Cell death&Disease. 2019,Sep 24; 10 (10):710. IF:6.211(共同通讯作者) 5.Jie Li#, Yuhan Duan#, Deming Zhao, Syed Zahid Ali Shah, Wei Wu, Xixi Zhang, Mengyu Lai, Zhiling Guan, Dongming Yang, Xiaoqian Wu, Hongli Gao, Huafen Zhao, Qi shi*, Lifeng Yang*. Detection of cell-free mitochondrial DNA in cerebrospinal fluid of Creutzfeldt-Jakob patients, Frontiers in Neurology. 2019,Jun 21;10: 645. IF:3.233(共同通讯作者) 6.Mengyu Lai#,Hao Yao#, Syed Zahid Ali Shah, Wei Wu, Di Wang, Ying Zhao, Lu Wang, Xiangmei Zhou, Deming Zhao, Lifeng Yang*. The NLRP3-Caspase 1 inflammasome negatively regulates autophagy via TLR4-TRIF in Prion peptide-infected microglia. Frontiers in Aging Neuroscience. 2018 Apr 18;10:116.IF:4.55 (通讯作者) 7.Syed Zahid Ali Shah, Zhao De Ming, Tariq Hussain, Naveed Sabir and Lifeng Yang*. Regulation of MicroRNAs-Mediated Autophagic Flux: A New Regulatory Avenue for Neurodegenerative Diseases with Focus on Prion Diseases. Frontiers in Aging Neuroscience. 2018 May 15;10:139..IF:4.55(通讯作者) 8.Chaosi Li, Di Wang, Wei Wu, Wei Yang, Syed Zahid Ali Shah,Ying Zhao, Yuhan Duan, Wang Lu, Xiangmei Zhou, Deming Zhao, Lifeng Yang*. DLP1-dependent mitochondrial fragmentation and redistribution mediate prion-associated mitochondrial dysfunction and neuronal death. Aging Cell, 2018 Feb;17(1). IF: 7.627(通讯作者) 9.Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain and Lifeng Yang*. Role of the AMPK Pathway in Promoting Autophagic Flux via Modulating Mitochondrial Dynamics in Neurodegenerative Diseases: Insight into Prion Diseases. Ageing Research Reviews . 2017 Nov;40:51-63. IF: 8.974(通讯作者) 10.Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain, Lifeng Yang*.The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases. Frontiers in aging neuroscience. 2017 May 1;9:120. IF: 4.504(通讯作者) 11.Wei Yang#, Li-feng Yang#, Zhi-qi Song, Syed Zahid Ali Shah, Yong-yong Cui, Chao-si Li, Hua-fen Zhao, Hong-li gao, Xiang-mei Zhou, and De-ming Zhao*. PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling, CNS Neuroscience & Therapeutics. 2017 May;23(5):416-427. IF: 4.063(共同第一作者) 12.Chunyu Wang#, Deming Zhao#, Syed Zahid Ali Shah, Wei Yang, Chaosi Li, and Lifeng Yang* . Proteome Analysis of Potential Synaptic Vesicle Cycle Biomarkers. Molecular Neurobiology. 2017 Sep;54(7):5177-5191. IF:6.190(通讯作者) 13.Syed Zahid Ali Shah, Tariq Hussain, Deming Zhao, and Lifeng Yang*. A Central Role for Calcineurin in Protein Misfolding Neurodegenerative Diseases, Cellular and Molecular life Science. 2017 Mar;74(6):1061-1074. IF:6.721(通讯作者) 14.Khan SH#, Zhao D#, Shah SZ, Hassan MF, Zhu T, Song Z, Zhou X, Yang L*. Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells .Cellular and Molecular Neurobiology. 2017 May, 37:717–728. IF:3.895(通讯作者) 15.Li Chaosi, Syed Zahid Ali Shah, Zhao Deming, Lifeng Yang*. Role of Retromer Complex in Neurodegenerative Diseases. Frontiers in Aging Neuroscience. 2016 Mar 1;8:42. IF:4.725(通讯作者) 16.Ting Zhu#, Deming Zhao#, Zhiqi Song, Zhen Yuan, Chaosi Li, Yunsheng Wang, Xiangmei Zhou, Xiaomin Yin, Muhammad Farooque Hassan, Lifeng Yang*. HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway. Neurobiology of Aging. 2016 Jan;37:91-102.IF: 5.22 (通讯作者) 17.Yongyao Fu#, Deming Zhao#, Bo Pan, Jihong Wang, Yongyong Cui, Fushan Shi, Chunyu Wang, Xiaoming Yin, Xiangmei Zhou, Lifeng Yang*. Proteomic analysis of protein expression throughout disease progression in a mouse model of Alzheimer’s disease. J Alzheimers Dis. 2015 Aug 11;47(4):915-26.IF:4.365(通讯作者) 18.Zhu Lin#, Deming Zhao #, Yunsheng Wang, Wei Zhao, Xiaomin Yin, Xiangmei Zhou, Zhongqiu Zhang, Lifeng Yang *. Downregulation of Beta-soluble NSF Attachment Protein (β-SNAP): Proteomics-based Identification in Early-stage Prion Disease. Neurodegenerative Diseases. 2015;15(4):193-201. IF:3.454(通讯作者) 19.Zhen Yuan#, Lifeng Yang#, Baian Chen, Ting Zhu, Mohammad Farooque Hassan, Xiaomin Yin, Xiangmei Zhou, Deming Zhao*. Protein misfolding cyclic amplification (PMCA) induces the conversion of recombinant prion protein to PrP oligomers causing neuronal apoptosis. Journal of Neurochemistry. 2015 Jun;133(5):722-9. IF:4.244(共同第一作者) 20.Yongyao Fu, Deming Zhao, Lifeng Yang*. Protein-based biomarkers in cerebrospinal fluid and blood for Alzheimer's disease. Journal of molecular neuroscience. 2014 Dec;54(4):739-47. IF:2.891(通讯作者) 【编(译)著、教材】 1.《大鼠和小鼠病理变化术语及诊断标准的规范》,中国农业出版社,2019年11月,主译。 2.《动物组织病理学彩色图谱》,中国农业大学出版社,2015年12月,主编。 3.《兽医病理学》第五版,中国农业出版社,2015年12月,主译。 4.《猪病学》第十版,中国农业出版社,2014年8月,主译。 5.《绵羊疾病学》第四版,中国农业出版社,2012年9月,主译。 6.《传染性海绵状脑病》,中国农业大学出版社,2012年2月,副主编。 7.《长爪沙鼠组织学图谱》,浙江工商大学出版社,2017年9月,副主编。 8.《实验室生物安全教程》,中国农业大学出版社,2010年8月,副主编。 9.《人类疾病动物模型》第2版,人民卫生出版社,2014年6月,参编。 10.《兽医临床病理解剖学》第二版,中国农业大学出版社,2015年2月,参编。 11.《动物病理学彩色图谱》,中国农业大学出版社,2012年10月,参编。 12.《动物传染性海绵状脑病》,中国农业出版社,2015年12月,参编。 13.《实验动物疫病学》,中国农业出版社,2015年1月,参编。 14.《奶牛疾病学》第二版,中国农业大学出版社,2009年12月,参译。 15.《猪病学》第九版,中国农业大学出版社,2008年2月,参译。 16.《动物传染性海绵状脑病》,中国农业出版社,2005年9月,参编。 17.《兽医病理解剖学》第四版,中国农业出版社,2018年2月,参编。 |