报告题目：逆转录病毒与天然限制因子的相互作用
报告人：王晓钧博士哈尔滨兽医研究所研究员
时间：2012年11月20日 14:00
地点：西区动医动科大楼B110室
联系人：王晓佳（wangxj@cau.edu.cn）
欢迎各位老师同学参加!
王晓钧博士，男，汉族。1974年出生于内蒙古。1996年在内蒙古民族大学获兽医学学士；1999年在中国农业科学院研究生院获预防兽医学硕士并到哈尔滨兽医研究所工作；2003年在中国农业科学院研究生院获预防兽医学博士学位。2005年－2010年留学美国密西根州立大学, 开展博士后研究；相关工作发表在Journal of Virology，Journal of Biological Chemistry, Plos Pathogen等杂志。2010年10月作为引进人才，受聘马病学科首席专家岗位，回到哈尔滨兽医研究所工作。现任大动物传染病研究室副主任和马病基础免疫研究组负责人，承担国家自然科学基金项目和OIE马流感参考实验室twinning项目等课题多项，是2012年首届国家优秀青年基金获得者。王晓钧实验室主要研究方向为病毒与感染细胞的相互作用和宿主抵抗病毒感染的天然免疫机制的研究。
近年发表论文：
1.Xiaojun Wang, Aierken Abudu, SungMo Son, Ying Dang, Patrick J. Venta, and Yong-Hui Zheng, Analysis of Human APOBEC3H Haplotypes and Anti-Human Immunodeficiency Virus Type-1 Activity. J Virol. 2011 Jan 26. [Epub ahead of print] doi:10.1128/JVI.02049-10
2.Xiaojun Wang *, Ying Dang*, IA York, Yong-Hui Zheng. Identification of a critical T(Q/D/E)x5ADx2(I/L) motif from primate lentivirus Vif proteins that regulate APOBEC3G and APOBEC3F neutralizing activity，J Virol. 2010 Sep;84(17):8561-70. Epub 2010 Jun 30
3.Xiaojun Wang, Yanxing Han, Ying Dang, William Fu, Tao Zhou, Roger G. Ptak, and Yong-Hui Zheng, Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication. J. Biol. Chem. Mar. 9, 2010 doi: 10.1074/ jbc .M110.109314.
4.Xiaojun Wang, Patrick T. Dolan, Ying Dang and Yong-Hui Zheng, Biochemical differentiation of APOBEC3F and APOBEC3G proteins associated with HIV-1 life cycle. J Biol Chem. 2007 Jan 19; 282(3):1585-94.
5.Lili Wei,Xiujuan Fan, Xiaoling Lu, Liping Zhao, Wenhua Xiang, Xiaoyan Zhang, Fei Xue, Yiming Shao, and Rongxian Shen, Xiaojun Wang **. Genetic Variation in the Long Terminal Repeat Associated with the Transition of Chinese Equine Infectious Anemia Virus from Virulence to Avirulence. Virus Gene, 2008, Jan 7.（**通讯作者）
6.Aierken Abudu, Xiaojun Wang, Ying Dang, Tao Zhou, Shi-Hua Xiang, and Yong-Hui Zheng, Identification of molecular determinants from moloney Leukemia virus 10 homolog (MOV10) protein for virion packaging and anti-human immunodeficiency virus type 1 (HIV-1) activity, J Biol Chem. 2011, First Published on November 21, 2011, doi: 10.1074/jbc.M111.309831
7.Tao Zhou, Xiufang Yuan, Shaohua Hou, Yabin Tu, Jinmei Peng, Jianxin Wen, Huaji Qiu, Donglai Wu, Huanchun Chen, Xiaojun Wang **, Guangzhi Tong **. Long terminal repeat sequences from virulent and attenuated equine infectious anemia virus demonstrate distinct promoter activities. Virus Res. 2007 Sep; 128(1-2):58-64.（**通讯作者）
8.Ying Dang, Xiaojun Wang, Tao Zhou, IA York, Yong-Hui Zheng. Identification of a novel WxSLVK motif in the N terminus of human immunodeficiency virus and simian immunodeficiency virus Vif that is critical for APOBEC3G and APOBEC3F neutralization J Virol. 2009 Sep; 83(17):8544-52. Epub 2009 Jun 17.
9.Yanxing Han, Xiaojun Wang, Ying Dang, Yong-Hui Zheng. Demonstration of a novel HIV-1 restriction phenotype from a human T cell line. PLoS ONE. 2008 Jul 30; 3(7):e2796.
10.Yanxing Han, Xiaojun Wang, Ying Dang, Yong-Hui Zheng. APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication. PLoS Pathog. 2008 Jul 4; 4(7):e1000095.
11.Ying Dang, Xiaojun Wang, WJ Esselman, Yong-hui Zheng. Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family. J Virol. 2006 Nov; 80(21):10522-33.
12. YingDang, LMSiew, XiaojunWang, YanxingHan, RLampen, Yong-hui Zheng. Human cytidine deaminase APOBEC3H restricts HIV-1 replication. J Biol Chem. 2008 Feb 25
13.Tao Zhou, Yanxing Han, Ying Dang, Xiaojun Wang, Yong-hui Zheng, A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR, Retrovirology 2009, 6:31doi:10.1186/1742-4690-6-31
