吴聪明，男，1968年2月出生，兽医药理学与毒理学博士，中国农业大学教授，博士生导师，动物医学院基础兽医学系主任，国家兽药安全评价中心副主任。1988.9-1992.7，在四川农业大学兽医系学习获学士学位（兽医公共卫生专业）；1992.9-1995.7，在四川农业大学动物科技学院学习获硕士学位（预防兽医学专业）；1995.7-2000.8，在广东海洋大学从事兽医教学科研工作；2000.9-2003.7，在华南农业大学兽医学院学习获博士学位（基础兽医学专业）；2003.8-2005.8，在中国农业大学兽医学博士后流动站工作；2005.9至今在中国农业大学动物医学院从事兽医药理学与毒理学科研教学工作。主研方向为兽药有效性和安全性评价、动物源耐药病原菌产生机制及风险评估。近5年来先后主持承担国家自然科学基金项目、国家科技支撑计划项目、公益性行业（农业）科研专项、973项目、863项目/课题/子课题等10余项；承担辉瑞、礼来、勃林格殷格翰、拜耳等制药企业委托的兽药有效性和安全性评价项目课题20余项。已发表学术论文近70篇（SCI收录论文30余篇）；申请国家发明专利10项（授权3项）；参加制定国家标准和行业标准19项（发布10项）；参编（译）著作3部。

代表性文章：

1. Li RC, Y Wang, JZ Shen, CM Wu. Development of a novel hexa-plex PCR method for identification and serotyping of Salmonella species. Foodborne Pathog Dis. 2014, 11: 75-77

2. He T, Y Wang, S Schwarz, Q Zhao, JZ Shen, CM Wu. Genetic environment of the multi-resistance gene cfr inmethicillin-resistant coagulase-negative staphylococci from chickens, ducks, and pigs in China. Int J Med Microbiol. 2013[doi: 10.1016/j.ijmm.2013.10.005]

3. Wang SC, Y Wang, JZ Shen, YN Wu, CM Wu. Polymorphic mutation frequencies in clinical isolates of Staphylococcus aureus: the role of weak mutators in the development of fluoroquinolone resistance. FEMS Microbiol Lett. 2013, 341: 13-17

4. Wang SC, CM Wu, JZ Shen,YN Wu, Y Wang. Hypermutable Staphylococcus aureus strains present at high frequency in subclinical bovine mastitis isolates are associated with the development of antibiotic resistance. Vet Microbiol. 2013, 165: 410-415

5. Li RC, J Lai, Y Wang, SL Liu, Y Li, KY Liu, JZ Shen, CM Wu. Prevalence and characterization of Salmonella species isolated from pigs, ducks and chickens in Sichuan Province, China. Int J Food Microbiol. 2013, 163: 14-18

6. Lai J, Y Wang, JZ Shen, RC Li, Jing Han, SL Foley, CM Wu. Unique class 1 integron and multiple resistance genes co-located on IncHI2 plasmid is associated with the emerging multidrug resistance of Salmonella Indiana isolated from chicken in China. Foodborne Pathog Dis. 2013, 10: 581-588

7. Wang Y, J Yang, CM Logue, KY Liu, XY Cao, WJ Zhang, JZ. Shen, CM Wu. Methicillin-resistant Staphylococcus pseudintermedius isolated from canine pyoderma in North China. J Appl Microbiol. 2012, 112: 623-630

8. Zhang WJ, ZH Hao, Y Wang, XY Cao, CM Logue, B Wang, J Yang, JZ Shen, CM Wu. Molecular characterization of methicillin-resistant Staphylococcus aureus strains from pet animals and veterinary staff in China. Vet J. 2011, 190(2): e125-129

9. Wang Y, S Schwarz, Z Shen,W Zhang, J Qi, Y Liu, T He,J Shen, CM Wu. Co-location of the multiresistance gene cfr and the novel streptomycin resistance gene aadY on a small plasmid in a porcine Bacillus strain. J Antimicrob Chemother. 2012, 67:1547-1549

10. NaRen GW, Y Wang, ZQ Shen, X Chen, JZ Shen, CM Wu.Rapid detection of point mutations in domain V of the 23S rRNA gene in erythromycin-resistant Campylobacter isolates by pyrosequencing.Foodborne Pathog Dis. 2011, 8:375-379

11. Huang SY, XQ Zhu, Y Wang, L Dai, ZH Wang, BB Li, CM Wu, JZ Shen.Correlation of fluoroquinolone resistance with expression of qnrA gene in Kluyvera spp. Foodborne Pathog Dis.2011, 8:1039-1044

12. Zhang WJ, CM Wu, Y Wang, ZQ Shen, L Dai, J Han, SL Foley, JZ Shen, QJ Zhang.The new genetic environment of cfr on plasmid pBS-02 in a Bacillus strain.J Antimicrob  Chemother. 2011, 66: 1174-1191

13. Li L, ZG  Jiang, LN Xia, JZ Shen, L Dai, Y Wang, SY Huang, CM Wu.Characterization of antimicrobial resistance and molecular determinants of beta-lactamase in Escherichia coli isolated from chickens in China during 1970–2007. Vet Microbiol. 2010, 144:505-510

14. Li BB, CM Wu, Y Wang, JZ Shen.Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit. J Antimicrob Chemother. 2011, 66:1983-1986

15. Li BB, JZ Shen, XY Cao, Y Wang, L Dai, SY Huang,  CM Wu. Mutations in 23S rRNA gene associated with decreased susceptibility to tiamulin and valnemulin in Mycoplasma gallisepticum.FEMS Microbiol Lett. 2010, 308:144-149

16. Lu LM, L Dai, Y Wang, CM Wu, X Chen, L Li, YH Qi, LN Xia, JZ Shen. Characterization of antimicrobial resistance and integrons among Escherichia coli isolated from animal farms in Eastern China. Acta Tropica. 2010, 113: 20–25

17. Xia LN, L Li, CM Wu, YQ Liu,XQ Tao, L Dai, YH Qi, LM Lu, JZ Shen. A Survey of Plasmid-Mediated Fluoroquinolone Resistance Genes from Escherichia Coli Isolates and Their Dissemination in China. Foodborne Pathog. Dis. 2010, 7: 207-215

18. Dai L, CM Wu, MG Wang, Y Wang, Y Wang, SY Huang, LN Xia, BB Li, JZ Shen.First Report of the Multidrug Resistance Gene cfr and the Phenicol Resistance Gene fexA in a Bacillus Strain from Swine Feces. Antimicrob Agents Chemother. 2010, 54:3953–3955

19. Chen X, GW Naren, CM Wu, Y Wang, L Dai, LN Xia, PJ Luo, QJ Zhang, JZ Shen. Prevalence and Antimicrobial Resistance of Campylobacter Isolates in Broilers from China. Vet. Microbiol. 2010, 144 : 133-139.

20. Wu CM, Y Li, JZ Shen, LL Cheng, YS Li, CY Yang, PS Feng, SX Zhang.LC–MS–MS Quantification of Four Quinoxaline-1,4-Dioxides in Swine Feed.Chromatographia. 2009, 70: 1605-1611

21. Huang SY, L Dai, LN Xia, XD Du, YH Qi, HB Liu, CM Wu, JZ Shen.Increased Prevalence of Plasmid-Mediated Quinolone Resistance Determinants in Chicken Escherichia coli Isolates from 2001 to 2007.Foodborne Pathog Dis. 2009, 6:1203-1209

22. Du XD, CM Wu, HB Liu, XS L, RC Beier, F Xiao, SS Qin, SY Huang, JZ Shen. Plasmid-mediated ArmA and RmtB 16S rRNA Methylases in Escherichia coli isolated from chickens. J. Antimicrob. Chemother. 2009, 64: 1328-1330

23. Qi YH, CM Wu, SX Zhang, ZH Wang, SY Huang, L Dai, SC Wang, LN Xia, K Wen, XY Cao, YN Wu, JZ Shen. Selection of Anti-Sulfadimidine Specific ScFvs from a Hybridoma Cell by Eukaryotic Ribosome Display. PloS ONE. 2009, 4: e6427

24. Liu MC, CM Wu, YC Liu, JC Zhao, YL Yang, JZ Shen. Identification, susceptibility, and detection of integron-gene cassettes of Arcanobacterium pyogenes in bovine endometritis. J. Dairy Sci. 2009, 92: 3659–3666

25. Wang SC, CM Wu, SC Xia, YH Qi, LN Xia, JZ Shen. Distribution of superantigenic toxin genes in Staphylococcus aureus isolates from milk samples of bovine subclinical mastitis cases in two major diary production regions of China. Vet. Microbiol. 2009, 137: 276–281

26. Wu CM, Y Wang, XY Cao, JC Lin, SS Qin, TJ Mi, SY Huang,  JZ Shen.Emergence of plasmid-mediated quinolone resistance genes in Enterobacteriaceae isolated from chickens in China.J Antimicrob Chemother. 2008, 63:408-411

27. Wang GQ, CM Wu, XD Du, ZQ Shen, LH Song, X Chen, JZ Shen. Characterization of integrons-mediated antimicrobial resistance among Escherichia coli strains isolated from bovine mastitis. Vet. Microbiol. 2008, 127: 73-78

28. Wang Y, CM Wu, LM Lu, GW Naren, XY Cao, JZ Shen. Macrolide-lincosamide-resistant phenotypes and genotypes of Staphylococcus aureus isolated from bovine clinical mastitis. Vet. Microbiol. 2008, 130 : 118-125

29. Dai L, LM Lu, CM Wu, BB Li, SY Huang, SC Wang, YH Qi, JZ Shen. Characterization of antimicrobial resistance among Escherichia coli isolates from chickens in China between 2001 and 2006. FEMS Microbiol. Lett. 2008, 286: 178-183

30. Cao XY, M Dong, JZ Shen, BB Wu, CM Wu, XD Du, Z Wang, YT Qi, BY Li. Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophage and monocytes. International J Antimicrob Agents. 2006, 27: 431-438

31. Wu CM, HM Wu, YB Ning, JG Wang, XD Du, JZ Shen. Induction of macrolide resistance in Mycoplasma gallisepticum in vitro and its resistance-related mutations within domain V of 23S rRNA. FEMS Microbiol Letters. 2005, 247: 199-205