主要从事动物源食品中抗菌药物、霉菌毒素、非法添加物等小分子化合物的半抗原设计、单抗体制备和体外进化、免疫分析检测原理与技术和抗体分子识别机制研究。主持和参与的科研项目30余项，包括国家自然科学基金、“十二五”科技支撑计划、“十三五”国家重点研发计划和科技部国际科技合作专项等。已在Anal Chem、Biosens Bioelectron、ACS Appl Mater Inter、分析化学和中国农业科学等学术刊物发表SCI收录论文120余篇，获授权国家发明专利50余项，开发出快速检测产品20余个；指导硕士、博士研究生20余名；担任Journal of Agricultural and Food Chemistry、Food Agricultural Immunology、Sensors、Biomolecules和食品安全质量检测学报等期刊编委。担任动物源食品安全检测技术北京市重点实验室副主任。中国仪器仪表学会食品质量安全检测仪器与技术应用分会副秘书长，中国畜牧兽医学会兽医药理与毒理学分会常务理事、科技部食品药品安全领域专家组成员等。

2002.09-2007.06 中国农业大学 动物医学院 博士

1998.09-2002.06 南京农业大学 动物医学院 本科

2016.01-至今   中国农业大学 研究员

2010.01-2015.12 中国农业大学 副教授

2007.07-2009.12 中国农业大学 讲师

动物源食品安全

兽药残留快速检测技术

兽医公共卫生学

兽医药理与毒理学

2019年 “高层次人才支持计划”领军人才

2016年 国家自然科学优秀青年基金获得者

2015年 国家技术发明奖二等奖

2013年 中华农业科技奖一等奖

2009年 全国优秀博士学位论文提名奖

2008年 北京市优秀博士学位论文奖

本科生 《药物化学》

研究生《兽药残留快速检测技术》

1.国家自然科学基金面上项目“半抗原疏水性对其免疫应答的影响机制研究”，2022-2025

2.北京市重点研究计划，重大活动中食物中毒快速检测技术及产品的研发， 2021-2024

3.十三五国家重点研发计划，单克隆抗体高通量精准筛选和制备新技术研究，2018-2021

4.国家自然科学基金面上项目“小分子化合物夹心免疫分析法中靶标物分子尺度极限的确定与验证研究”，2019-2022

5.十三五国家重点研发计划，中欧食品安全合作 H2020 EU-China-Safe，2018-2021

1.Chenglong Li, Huijuan Yang, Wenbo Yu, Xuezhi Yu, Kai Wen, Jianzhong Shen, Zhanhui Wang*. Engineering of organic solvent-tolerant antibody to sulfonamides by CDR grafting for analytical purposes. Analytical Chemistry, 2021, 93, 6008-6012. 封面文章 https://pubs.acs.org/toc/ancham/93/15. 

2.Yuchen Bai, Hui Jiang, Yingjie Zhang, Leina Dou, Minggang Liu, Wenbo Yu, Kai Wen, Jianzhong Shen, Yuebin Ke, Xuezhi Yu, Zhanhui Wang*. Hydrophobic moiety of capsaicins hapten enhancing antibody performance in immunoassay: evidences from computational chemistry and molecular recognition. Journal of Agricultural and Food Chemistry, 2021, 69, 34, 9957–9967. 封面文章 https://pubs.acs.org/toc/jafcau/69/34. 

3.Ghulam Mujtaba Mari, Hongfang Li, Baolei Dong, Huijuan Yang, Aisha Talpur, Jiafei Mi, Liuchuan Guo, Xuezhi Yu, Yuebin Ke, Dianggang Han, Zhanhui Wang*. Hapten synthesis, monoclonal antibody production and immunoassay development for direct detection of 4-hydroxybenzehydrazide in chicken, the metabolite of nifuroxazide. Food Chemistry, 2021, 355, 129598.

4.Kai Wen#, Yuchen Bai#, Yujie Wei, Chenglong Li, Suxia Zhang, Jianzhong Shen, Zhanhui Wang*. Influence of Hapten Properties on Antibody Response. Journal of Agricultural and Food Chemistry, 2020, 

5.Baolei Dong#, Hongfang Li#, Jiefang Sun, Yuan Li, Ghulam Mujtaba Mari, Xuezhi Yu, Wenbo Yu, Kai Wen, Jianzhong Shen*, Zhanhui Wang*. Magnetic and cost-effective fluorescent immunoassay for sensitive chloramphenicol detection based on the carbon dots-encapsulated calcium carbonate nanocomposites. Journal of Hazardous Materials, 2021, 402, 12394

6.Hongfang Li, Baolei Dong, Huiyan Zhang, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Kai Wen, Zhanhui Wang*. Fluorescent lateral flow immunoassay for the highly sensitive detection of eight anticoagulant rodenticides based on cadmium–free quantum dot–encapsulated nanospheres, Sensors and Actuators B: Chemical, 2020,

7.Ling Yang, Xiya Zhang, Dongshuai Shen, Xuezhi Yu, Yuan Li, Kai Wen, Jianzhong Shen, Zhanhui Wang*. Hapten synthesis and antibody to fluoroacetamide, a super-small and high-toxic chemical. Biomolecules, 2020, 10, 986.

8.Hongfang Li, Kai Wen, Baolei Dong, Jing Zhang, Yuchen Bai, Minggang Liu, Peipei Li, Mari Ghulam Mujtaba, Xiya Zhang, Xuezhi Yu, Wenbo Yu, Yuebin Ke, Jianzhong Shen, Zhanhui Wang*. Novel inner filter effect-based fluorescence immunoassay with gold nanoclusters for bromadiolone detection in human serum. Sensors and Actuators B: Chemical, 2019, 297, 126787.

9.Huiyan Zhang, Karl De Ruyck, Natalia Beloglazova*, Shupeng Yang, Sergei A. Eremin, Sarah De Saeger, Suxia Zhang, Jianzhong Shen, Zhanhui Wang*. Fluorescence polarization assay for chemical contaminants in food and environmental analysis. Trend in Analytical Chemistry, 2019, 114, 293–313.

10.Chenglong Li, Xiao Liang, Kai Wen, Yonghan Li, Xiya Zhang, Mingfang Ma, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Zhanhui Wang*. Class-specific monoclonal antibodies and dihydropteroate synthase in bioassays used for the detection of sulfonamides: structural insights into recognition diversity. Analytical Chemistry, 2019, 91, 2392–2400.

11.Ling Yang, Hengjia Ni, Suxia Zhang, Ghulam Mujtaba Mari, Yuebin Ke, Kai Wen, Huijuan Yang, Weimin Shi, Jianzhong Shen, Zhanhui Wang*. Development of a highly specific chemiluminescence aptasensor for sulfamethazine detection in milk based on in vitro selected aptamers. Sensors and Actuators B: Chemical, 2019, 271, 801–811. 

12.Baolei Dong, Sijun Zhao, Hongfang Li, Kai Wen, Jianzhong Shen, Suxia Zhang, Weimin Shi, Zhanhui Wang*. Design, synthesis and characterization of tracers and development of a fluorescence polarization immunoassay for the rapid detection of ractopamine in pork. Food Chemistry, 2019, 271, 9–17. 

13.Xiao Liang, Chenglong Li, Xiaoli Song, Suxia Zhang, Jing Zhang, Qidi Zhang, Jianzhong Shen, Zhanhui Wang*. Dihydropteroate synthase based sensor for screening multi-sulfonamides residue and its comparison with broad-specific antibody based immunoassay by molecular modeling analysis, Analytica Chimica Acta, 2019, 1050, 139–145.

14.Hongfang Li, Shaoqin Ma, Xiya Zhang, Chenglong Li, Baolei Dong, Mari Ghulam Mujtaba, Yujie Wei, Xuezhi Yu, Kai Wen, Wenbo Yu, Jianzhong Shen, Zhanhui Wang*. Generic haptens synthesis, broad-specific monoclonal antibodies preparation and ultrasensitive ELISA for five antibacterial synergists in chicken and milk. Journal of Agricultural and Food Chemistry, 2018, 66:10931–11196. 封面文章：https://pubs.acs.org/doi/10.1021/acs.jafc.8b03834

15.Chaochao Chen, Jiaxun Luo, Chenglong Li, Mingfang Ma, Wenbo Yu, Jianzhong Shen. Zhanhui Wang*. Molecularly imprinted polymer as an antibody substitution in pseudo-immunoassays for chemical contaminants in food and environmental samples. Journal of Agricultural and Food Chemistry, 2018, 66, 2561–2571.

16.Huiyan Zhang, Shupeng Yang, Ross C. Beier, Natalia V. Beloglazova, Hongtao Lei, Xiulan Sun, Yuebin Ke, Suxia Zhang, Zhanhui Wang*. Simple, high efficiency detection of microcystins and nodularin-R in water by fluorescence polarization immunoassay. Analytica Chimica Acta, 2017, 992, 119–127. 

17.Xiya Zhang, Kai Wen, Xuezhi Yu, Chenglong Li, Haiyang Jiang, Jianzhong Shen, Zhanhui Wang*. Multiplex lateral flow immunoassay based on amorphous carbon nanoparticles based multiplex lateral flow immunoassay for simultaneous detection of three mycotoxins Fusantium mycotoxins in maize. Journal of Agricultural and Food Chemistry, 2017, 65, 8063–8071.

18.Zhanhui Wang, Ross C. Beier, Jianzhong Shen*. Immunoassays for detection of macrocyclic lactones in food matrices — a review. Trends in Analytical Chemistry, 2017, 92, 42–61.

19.Xiya Zhang, Sergei A. Eremin, Kai Wen, Xuezhi Yu, Chenglong Li, Yuebin Ke, Haiyang Jiang, Jianzhong Shen, Zhanhui Wang*. Fluorescence polarization immunoassay based on a new monoclonal antibody for the detection of the zearalenone class of mycotoxins in maize. Journal of Agricultural and Food Chemistry, 2017, 65, 2240–2247.

20.Mingfang Ma, Chenglong Li, Xuezhi Yu, Kai Wen, Suxia Zhang, Jianzhong Shen, Zhanhui Wang*. Chemiluminescence resonance energy transfer competitive immunoassay employing hapten-functionalized quantum dots for the detection of sulfamethazine. ACS Applied Materials & Interfaces, 2016, 8, 17745−17750. 

21.Chenglong Li, Kai Wen, Tiejun Mi, Xiya Zhang, Huiyan Zhang, Suxia Zhang, Jianzhong Shen, Zhanhui Wang*. A universal multi-wavelength fluorescence polarization immunoassay for multiplexed detection of mycotoxins in maize. Biosensors & Bioelectronics, 2016, 79, 258–265. 

22.Chenglong Li, Tiejun Mi, Gea Oliveri Conti, Qing Yu, Kai Wen, Jianzhong Shen, Margherita Ferrante, Zhanhui Wang*. Development of a screening fluorescence polarization immunoassay for the simultaneous detection of fumonisins B₁ and B₂ in maize. Journal of Agricultural and Food Chemistry, 2015, 63, 4940–4946. 

23.李永翰， 温 凯，于雪芝，李成龙， 王战辉*. 磺胺类药物单链抗体的制备及其与磺胺噻唑相互作用研究. 分析化学，2015，43(3):366–370. 

24.Zhanhui Wang, Meixuan Liu, Weimin Shi, Chenglong Li, Suxia Zhang*, Jianzhong Shen. New haptens and antibodies for ractopamine. Food Chemistry, 2015, 183, 111–114.

25.Zhanhui Wang#, Xiao Liang#, Suxia Zhang, Kai Wen, Chenglong Li, Jianzhong Shen*. A highly sensitive and class-specific fluorescence polarisation assay for sulphonamides based on dihydropteroate synthase, Biosensors & Bioelectronics, 2015, 70, 1–4.

26.Qing Yu, Heng Li, Chenglong Li, Suxia Zhang, Jianzhong Shen, Zhanhui Wang*. Gold nanoparticles-based lateral flow immunoassay with silver staining for simultaneous detection of fumonisin B1 and deoxynivalenol in maize. Food Control, 2015, 54, 347–352.

27.Zhanhui Wang, Tiejun Mi, Huiyan Zhang, Yajie Sheng, Weimin Shi, Suxia Zhang, Jianzhong Shen*. Hapten synthesis, monoclonal antibody production, and development of a competitive indirect enzyme-linked immunosorbnent assay for erythromycin in milk. Food Chemistry, 2015, 171, 98–107.

授权专利

1.王战辉、吴伟林、刘佳靓，杨舒宇、朱建宇。硝呋烯腙半抗原和人工抗原及其制备方法与应用。授权号：ZL 202010158357.8

2.王战辉、沈建忠、温凯、江海洋、于雪芝、余文博、李红芳、段长飞、史为民。抗凝血剂鼠药半抗原合成及其制备方法与应用。授权号：ZL 201910152728.9 

3.沈建忠、王战辉、于雪芝、杨慧娟、温凯、江海洋、张素霞、史为民，郭柳川。溴敌隆纳米抗体的制备及应用。授权号：ZL 201911268156.7 

4.沈建忠，王战辉，温凯，江海洋，朱建宇，张素霞，史为民，李红芳。一种二羟鬼笔毒肽人工抗原及其制备方法与应用。授权号：ZL 201910152481.0 

5.王战辉，沈建忠，温凯，江海洋，杨玲，史为民，张西亚，张素霞。一种氟乙酰胺半抗原及单克隆抗体的制备方法与应用。ZL 201811324738.8 

6.温凯，王战辉，江海洋，周旭平，段长飞，马立才，谢冰，刘河兵，张英杰，覃丹凤。一种阿苯达唑人工抗原合成及其制备方法和应用。授权号：ZL 201910153401.3

7.沈建忠、王战辉、江海洋、温凯、余文博、于雪芝、李红芳、段长飞、史为民、张素霞。华法林半抗原和人工抗原及其制备方法与应用。授权号：ZL 201910152522.6，申请日：2019年2月28日

8.王战辉，李红芳，马少芹，沈建忠，温凯。磺胺增效剂半抗原和全抗原及其制备方法和应用。ZL 201810450544.6 

9.沈建忠，王战辉，温凯，于雪芝，江海洋，柯跃斌，朱建宇，史为民，张素霞，张西亚。一种利巴韦林半抗原和人工抗原的合成及应用。201811367056.5

10.沈建忠，王战辉，温凯，于雪芝，江海洋，柯跃斌，朱建宇，史为民，张素霞，张西亚。利巴韦林半抗原和人工抗原的合成及应用。ZL 201811367056.5

11.王战辉、沈建忠、温凯、李成龙、柯跃斌、张素霞、史为民。磺胺类药物半抗原和人工抗原及其制备方法与应用。专利号：ZL 201910138537.7 

13.王战辉、沈建忠、温凯、江海洋、张素霞、史为、张西亚、唐倩倩、李红芳。4, 4’-二硝基苯脲半抗原和人工抗原及其制备方法与应用. 专利号：ZL 201910536490.X 

14.王战辉，沈建忠，李红芳，张素霞，史为民，温凯，杨慧娟. 一种用于检测莫西菌素的多克隆抗体及其制备方法和应用. ZL 201710229076.5 

15.王战辉，张素霞，史为民，曹明慧，杨慧娟. 一种青霉震颤素结合抗原及其抗体的制备与应用. ZL 201610928188.5

16.王战辉，沈建忠，史为民，张素霞，温凯，梁晓，曹艳欣. 磺胺类半抗原及其结合抗原的制备方法与应用. ZL 201610941345.6

17.沈建忠、王战辉、江海洋、丁双阳、张素霞、史为民、吴聪明、曹兴元、夏曦. 三聚氰胺、喹诺酮类二合一金标微孔试纸条. 2013106164867

18.沈建忠、王战辉、蒋文晓、史为民、江海洋、张素霞、丁双阳、曹兴元、李建成；用于检测磺胺二甲基嘧啶和恩诺沙星的酶联免疫试剂盒及其应用；授权号：ZL 201310078523.3