朱要宏,女,博士,教授,博士生导师,教育部“新世纪优秀人才支持计划”入选者。1970年11月生,内蒙古集宁人。1993年毕业于中国农业大学动物医学院获学士学位(5年制),同年就职于北京大发正大有限公司技术部从事技术服务工作。1999年02月赴丹麦奥胡斯大学动物健康与生物科学系进修学习,2000年09月赴瑞典农业科学大学兽医与动物科技学院学习深造,于2002年08月获动物营养学硕士学位,2007年10月获兽医产科学博士学位。2007年底回国,到中国农业大学动物医学院工作。2009年晋升为副教授,2010年入选“教育部新世纪优秀人才支持计划”,2017年晋升为教授。长期从事兽医产科学、动物营养与免疫学等领域的教学、科研和临床工作。 主要研究方向包括:(1)动物乳房炎发病机理、诊断与防控技术研究;(2)动物子宫内膜炎诊断与防控技术研究;(3)动物源性大肠杆菌病和沙门菌病防控技术研究与示范;和(4)益生菌调控动物微生态环境与黏膜免疫的应用研究。主持国家(省部)级科研项目10余项;参与完成瑞典环境与农业科学研究委员会资助项目2项。主编或副主编出版著作4部,已发表SCI收录论文29篇,其中以第一或通讯作者在“Frontiers in cellular and infection microbiology”、“Veterinary Research”、“Journal of Animal Science”等刊物发表SCI收录论文23篇。 专业领域 兽医产科学、动物营养与免疫学 学习、培训及工作经历 2017.12 - 至今,任中国农业大学动物医学院教授,从事教学与科研工作。 2009.12 - 2017.12,任中国农业大学动物医学院副教授,从事教学与科研工作。 2007.12 - 2009.12,任中国农业大学动物医学院讲师,从事教学与科研工作。 2002.10 - 2007.10,赴瑞典农业科学大学,攻读并获得兽医产科学博士学位。 2000.09 - 2002.08,赴瑞典农业科学大学,攻读并获得动物营养学硕士学位。 1999.02 - 2000.01,赴丹麦奥胡斯大学动物健康与生物科学系进修学习。 1993.07 - 1999.01,于北京大发正大有限公司技术部从事技术服务工作。 1988.09 - 1993.07,于中国农业大学攻读并获得兽医学士学位。 讲授课程 主讲本科生课程“兽医产科学”,研究生课程“兽医产科学专题”,参讲“动物营养与免疫学专题”、“临床兽医学专业Seminar”等。 科研项目 主持国家自然科学基金项目2项,公益性行业(农业)科研专项课题1项,“十三五”国家重点研发计划项目任务1项,教育部“新世纪优秀人才支持计划”等国家(省部)级科研项目10余项;参与完成瑞典环境与农业科学研究委员会资助项目2项。 代表性论文(*通讯作者) 1.Zhang W#, Zhu YH#, Yang GY, Liu X, Xia B, Hu X, Su JH, Wang JF. 2018. Lactobacillus rhamnosus GG Affects Microbiota and Suppresses Autophagy in the Intestines of Pigs Challenged with Salmonella Infantis. Front Microbiol. 8:2705. (SCI IF = 4.08) 2.Yu J, Zhu YH, Yang GY, Zhang W, Zhou D, Su JH, Wang JF. 2017 Anti-inflammatory capacity of Lactobacillus rhamnosus GG in monophasic variant Salmonella infected piglets is correlated with impeding NLRP6-mediated host inflammatory responses. Vet. Microbiol. 210:91-100. (SCI IF = 2.63) 3.Yang GY, Yu J, Su JH, Jiao LG, Liu X, Zhu YH*. 2017. Oral administration of Lactobacillus rhamnosus GG ameliorates Salmonella Infantis-induced inflammation in a pig model via activation of the IL-22BP/IL-22/STAT3 pathway. Front. Cell. Infect. Microbiol. 7:323. (SCI IF = 4.92) 4. hang W, Zhu YH*, Zhou D, Wu Q, Song D, Dicksved J, Wang JF. 2017. Oral administration of a select mixture of Bacillus probiotics affects the gut microbiota and goblet cell function following Escherichia coli challenge in newly weaned pigs of genotype MUC4 that are supposed to be enterotoxigenic E. coli F4ab/ac receptor negative. Appl. Environ. Microbiol. 83: e02747 (SCI IF = 4.49) 5.Yang GY#, Zhu YH#, Zhang W, Zhou D, Zhai CC, Wang JF. 2016. Influence of orally fed a select mixture of Bacillus probiotics on intestinal T-cell migration in weaned MUC4 resistant pigs following Escherichia coli challenge. Vet. Res. 47:71. (SCI IF = 3.85) 6.Wu Q, Liu MC, Yang J, Wang JF, Zhu YH*. 2016. Lactobacillus rhamnosus GR-1 ameliorates Escherichia coli–induced inflammation and cell damage via attenuation of ASC-independent NLRP3 inflammasome activation. Appl. Environ. Microbiol. 82:1173-1182. (SCI IF = 4.49) 7.Cai DJ, Song QJ, Wang JF, Zhu YH*. 2016. Genomic characterization of three bovine viral diarrhea virus isolates from cattle. Arch. Virol. 161:3589-3592 (SCI IF = 2.25) 8.Zhou D#, Zhu YH#, Zhang W, Wang ML, Fan WY, Song D, Yang GY, Jensen BB, Wang JF. 2015. Oral administration of a select mixture of Bacillus probiotics generates Tr1 cells in weaned F4ab/acR− pigs challenged with an F4+ ETEC/VTEC/EPEC strain. Vet. Res. 46:95. (SCI IF = 3.85) 9.Zhang W#, Zhu YH#, Yang JC, Yang GY, Zhou D, Wang JF. 2015. A selected Lactobacillus rhamnosus strain promotes EGFR-independent Akt activation in an enterotoxigenic Escherichia coli K88-Infected IPEC-J2 cell model. PLoS One. 10:e0125717. (SCI IF = 4.02) 10.Wu Q, Yao HD, Tan SR, Zhang ZW, Zhu YH*, Xu SW. 2014. Possible correlation of selenoprotein W with inflammation factors in chicken skeletal muscles. Biol. Trace Elem. Res. 161:167-172. (SCI IF = 1.66) 11.Zhang FJ, Weng XG, Wang JF, Zhou D, Zhang W, Zhai CC, Hou YX, Zhu YH*. 2014. Effects of temperature-humidity index and chromium supplementation on antioxidant capacity, heat shock protein 72, and cytokine responses of lactating cows. J. Anim. Sci. 92:3026-3034. (SCI IF = 2.55) 12.Zhu YH, Li XQ, Zhang W, Zhou D, Liu HY, Wang JF. 2014. Dose-dependent effects of Lactobacillus rhamnosus on serum interleukin-17 production and intestinal T-cell responses in pigs challenged with Escherichia coli. Appl. Environ. Microbiol. 80:1787-1798. (SCI IF = 4.49) 13.Li XQ#, Zhu YH#, Zhang HF, Yue Y, Cai ZX, Lu QP, Zhang L, Weng XG, Zhang FJ, Zhou D, Yang JC, Wang JF. 2012. Risks associated with high-dose Lactobacillus rhamnosus in an Escherichia coli model of piglet diarrhoea: intestinal microbiota and immune imbalances. PLoS One. 7:e40666. (SCI IF = 4.02) 14.Zhu YH, Liu PQ, Weng XG, Zhuge ZY, Zhang R, Ma JL, Qiu XQ, Li RQ, Zhang XL, Wang JF. 2012. Pheromonicin-SA affects mRNA expression of toll-like receptors, cytokines, and lactoferrin by Staphylococcus aureus–infected bovine mammary epithelial cells. J. Dairy Sci. 95:759-764. (SCI IF = 3.08) 15.Zhuge ZY#, Zhu YH#, Liu PQ, Yan XD, Yue Y, Weng XG, Zhang R, Wang JF. 2012. Effects of Astragalus Polysaccharide on Immune Responses of Porcine PBMC Stimulated with PRRSV or CSFV. PLoS One. 7:e29320. (SCI IF = 4.02) 16.Ma JL#, Zhu YH#, Zhang L, Zhuge ZY, Liu PQ, Yan XD, Gao HS, Wang JF. 2011. Serum concentration and mRNA expression in milk somatic cells of toll-like receptor 2, toll-like receptor 4, and cytokines in dairy cows following intramammary inoculation with Escherichia coli. J. Dairy Sci. 94:5903-5912. (SCI IF = 3.08) 17.Li X#, Zhu YH#, Liu P, Zhuge Z, Su G, Wang J. 2010. Assessment of genetic diversity in Chinese eared pheasant using fluorescent-AFLP markers. Mol. Phylogenet. Evol. 57: 429-433. (SCI IF = 3.87) 18.Zhang L, Xu YQ, Liu HY, Lai T, Ma JL, Wang JF, Zhu YH*. 2010. Evaluation of Lactobacillus rhamnosus GG using an Escherichia coli K88 model of piglet diarrhoea: Effects on diarrhoea incidence, faecal microflora and immune responses. Vet. Microbiol. 141:142-148. (SCI IF = 3.12) 19.Zhu YH, Magnusson U, Fossum C, Berg M. 2008. Escherichia coli inoculation of porcine mammary glands affects local mRNA expression of Toll-like receptors and regulatory cytokines. Vet. Immunol. Immunopathol. 125:182-189. (SCI IF = 1.96) 20.Zhu YH, Berg M, Fossum C, Magnusson U. 2007a. Proinflammatory cytokine mRNA expression in mammary tissue of sows following intramammary inoculation with Escherichia coli. Vet. Immunol. Immunopathol. 116:98-103. (SCI IF = 1.96) 21. Zhu YH, Fossum C, Berg M, Magnusson U. 2007b. Morphometric analysis of proinflammatory cytokines in mammary glands of sows suggests an association between clinical mastitis and local production of IL-1beta, IL-6 and TNF-alpha. Vet. Res. 38:871-882. (SCI IF = 4.13) 主要著作 1.朱要宏(主编).犬猫临床用药手册(第2版).北京:中国农业出版社,2018. 2.朱要宏(主编).犬猫临床用药手册(第1版).北京:中国农业出版社,2015. 3.朱要宏(副主编之一).小动物内科学. 王九峰主编. 北京:中国农业出版社,2013. 4.朱要宏(副主编之一).动物保护学. 赵兴波主编. 北京:中国农业大学出版社,2011. |