中国农业大学教授，教育部“新世纪优秀人才”支持计划入选者。1991年毕业于兰州大学生物系生物化学专业，1994年获河北师范大学细胞生物学硕士学位，导师孙大业院士。1995年赴美深造，于2001年获美国麻省大学分子和细胞生物学博士学位。2001年至2008年在美国宾夕法尼亚学医学院做博士后、高级研究员。在博士后期间，分获宾西法尼亚大学基因治疗研究所和美国国家健康研究院(NIH)博士后基金。2009年4月起受聘于中国农业大学动物医学院，组建成立分子细胞生物学研究室。近5年来先后主持承担“新世纪优秀人才支持计划”项目、国家自然科学基金项目、农业生物技术国家重点实验室自主研究项目、留学回国人员科研启动项目等。以第一作者和通讯作者身份在Nature Cell Biology，Gene&Development，Oncogene，Journal of Biological Chemistry，J. Virol和DNA Repair等国际知名刊物发表论文多篇。近5年共发表SCI论文19篇，累计影响因子79.482。以第一发明人获得发明专利一项。 研究兴趣主要集中在细胞应激的信号转导及分子与病理机制，具体方向包括：1) 比较肿瘤学与细胞信号转导调控（Comparative Oncology & Signaling Transduction），主要以禽类和伴侣动物多发的肿瘤性疾病为模型，与人类肿瘤疾病进行比较医学方面的研究，侧重于研究肿瘤发生和发展的信号转导机制及调控途径。2) 模式病毒与宿主相互作用机制（Herpes virus & Host Interaction），主要以人类和动物模式病毒（如疱疹病毒HSV-1和PRV等）为模型和载体，研究病毒感染与宿主间的相互作用机制，为动物和人类肿瘤疾病的基因和药物治疗提供载体。3）亚细胞核体（PML-NBs）的功能与调控。4）化学小分子的抗肿瘤和抗病毒活性。 代表性文章： 1. Zheng J, Lang Y, Zhang Q, Cui D, Sun H, Jiang J, Jiang L, Chen Z, Zhang R, Gao Y, Tian W, Wu W, *Tang J, *Chen Z. Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation. Gene & Development Accepted (IF=12.63) 2. Geng Y, Wang X, Yang L, Sun H, Wang Y, Zhao Y, She R, Wang MX, *Wang DX, *Tang J. (2015)Antitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One-Based Synthetic Small Molecule In Vitro and In Vivo. PLoS One 10(6):e0128928. (IF=3.534) 3. Xu Z, Cheng W, Guo K, Yu J, *Shen J, *Tang J, Yang W, *Yin M. (2015) The molecular size, shape and electric charges are essential for perylene bisimides-based DNA intercalator to localize in cell nuclei and inhibit cancer cell growth. ACS Applied Materials & Interfaces 7(18):9784-91 (IF=5.9) 4. Xu A, Qin C, Lang Y, Wang M, Lin M, Li C, Zhang S, *Tang J. (2015) A simple and rapid approach to manipulate Pseudorabies virus genome by CRISPR/Cas9 system. Biotechnology Letters 37(6):1265-72 (IF=1.73) 5. Wang Z, Xu A, Hou X, Chen F, Cao W, Yu J, Liao M, *Tang J. (2014) COP9 signalosome subunit 6 binds and inhibits avian leukosis virus integrase. Biochem Biophys Res Commun 453(3):527-32 (IF=2.281) 6. Cui D., Li LJ, Lou HJ., Sun HL, Ngai S-M, Shao GZ, and *Tang J. (2014) The ribosomal protein S26 regulates p53 activity in response to DNA damage. Oncogene 33(17):2225-35 (IF=8.559) 7. Xu Z, Guo K, Yu J, Sun H, Tang J, Shen J, Müllen K, Yang W, Yin M. (2014) A unique perylene-based DNA intercalator: localization in cell nuclei and inhibition of cancer cells and tumors. Small. 10(20):4087-92 (IF=7.51) 8. Huang C, Zhang Q, Guo XK, Yu ZB, Xu AT, Tang J, Feng WH. (2014) Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-κB essential modulator. J Virol. 88(18):10934-45 (IF=4.648) 9. Bi Y, Guo XK, Zhao H, Gao L, Wang L, Tang J, Feng WH. (2014) Highly pathogenic porcine reproductive and respiratory syndrome virus induces prostaglandin E2 production through cyclooxygenase 1, which is dependent on the ERK1/2-p-C/EBP-β pathway. J Virol. 88(5):2810-20 (IF=4.648) 10. Wang L, Hou J, Gao L, Guo XK, Yu Z, Zhu Y, Liu Y, Tang J, Zhang H, Feng WH. (2014) Attenuation of highly pathogenic porcine reproductive and respiratory syndrome virus by inserting an additional transcription unit. Vaccine. 32(43):5740-8 (IF=3.48) 11. Tang J., Agrawal T., Cheng Q., Qu L., Brewer MD., Chen J., Yang X. (2013) Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation. PLoS One 8(2):e55813 (IF=3.534) 12. Ma ZT, Wang YL, Zhao HY, Xu AT, Wang YQ, *Tang J., *Feng WH. (2013) Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Induces Apoptosis Dependent on Its 3C-Like Serine Protease Activity. PLoS One 8(7):e69387. (IF=3.534) 13. Geng YY., Monajembashi S., Shao AW., Cui D., He WY., Chen Z., Hemmerich P., *Tang J. (2012) Contribution of the C-terminal regions of Promyelocytic leukemia protein (PML) isoform II and V to PML nuclear body formation. J Biol Chem 287(36):30729-42 (cover story) (IF=4.6) 14. Li LJ., Cui D., Zheng S.J., Lou HJ., *Tang J. (2012) Regulation of Actinomycin D induced upregulation of Mdm2 in H1299 cells. DNA Repair (Amst). 11(2):112-9 (IF=3.362) 15. Fu Y., Quan R., Zhang H., Hou J., *Tang J., *Feng WH. (2012) Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Induces Interleukin-15 through the NF-κB Signaling Pathway. J Virol. 86(14):7625-36 (IF=4.648) 16. Wang J., Wang Y., Liu J., Ding L., Zhang Q., Li X., Cao H., *Tang J., *Zheng S.J. (2012) A critical role of N-myc and STAT interactor (Nmi) in Foot-and-Mouth Disease Virus (FMDV) 2C-induced apoptosis. Virus Research 170(1-2):59-65. (IF=2.827) 17. Chen K., Luo Z., *Tang J., and *Zheng S.J. (2011) A critical role of Heat shock cognate protein 70 in Apoptin-induced phosporylation of Akt. Biochem Biophys Res Commun 409:200-4 (IF=2.281) 18. *Tang J., Qu L., Pang MS., Yang X. (2010) Daxx is reciprocally regulated by Mdm2 and Hausp. Biochem Biophys Res Commun 393：542-5 (IF=2.281) 19. Pang P.,Chen FY., Tang J., Ma JC. Wang JC., Zheng S.J. (2010) Avian leukosis virus p27 inhibits tumor necrosis factor α expression in RAW264.7 macrophages after stimulation with lipopolysaccharide. Acta virologica 54: 119-124 (IF=1.03) 20. Tang J., Qu L., Zhang J., Wang W., Michaelson JS., Degenhardt Y., El-Deiry WS., and Yang X. (2006) Critical role for Daxx in regulating Mdm2. Nature Cell Biol. 8(8): 855-62 21. Tang J., Kawadler H., Yang X. (2005) Lymphocyte Life and Death: The Caspase-8 Connection. Cancer Biol Ther. 4(7): 700-2 22. Tang J., Xie W., Yang X. (2005) Association of Caspase-2 with the Promyelocytic Leukemia Protein Nuclear Bodies. Cancer Biol Ther. 4(6): 645-649 23. Tang J., Chang HY., Yang X. (2005) The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62. FEBS Lett. 579(13):2883-90 |
