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姓名:许剑琴 性别: 职务:中兽医学分会理事长、会长
所在系: 临床兽医系 职称:教授 导师类别:博导/硕导
政治面貌: 出生年月:1956.11 学位:学士
电子邮件:jianqinxucau@126.com 办公电话:010-62734111
个人简介:

教授,博导。男,汉族,1956年11月28日出生于江苏省东台市。1978年3月入南京农业大学畜牧兽医系兽医专业学习。1982年2月到中国农业大学(原北京农业大学)动物医学院从事中兽医学教学和科研工作。现兼任中国兽医协会中兽医分会会长;中兽药产业技术创新战略联盟理事长;中华人民共和国农业部新兽药审评专家;《中华人民共和国兽药典》委员会委员。《中国兽医杂志》、《中兽医医药杂志》、《动物医学进展》和《动物保健品信息》期刊编委,《中兽医学杂志》副主编。

主要教学工作:自参加工作以来,主讲过家畜病理生理学、兽医针灸学、兽医中药学、中兽医方剂学、中兽医内科学、中兽医外科学以及中兽医学等。为研究生讲授了中药方剂专题、中兽医古籍选读、中兽医研究进展等课程;为兽医大专函授班以及台湾或国外学员讲授了中兽医学,针灸学等课程。

主要科研工作:目前主持“十二五”国家科技支撑计划重点项目“现代中兽药研究与新药创制”(项目首席专家)及其重点课题“防治畜禽呼吸、消化系统常见病证中兽药创制及应用示范(2011BAD34B01)”、农业部公益性行业(农业)科研专项子课题“猪重要脾胃病辨证施治关键技术研究与示范(201403051-07)”和“家畜生产运输应激模型的建立及药物评价芯片的研制与开发(201003060-10)”2项;主持并完成“十一五”国家科技支撑计划项目重点课题“中兽药药效评价模型及其关键技术研究(2008BADB4B01)”和“大蒜挥发油活性部位新制剂的研究与开发(2006BAD31B05-2)”2项;主持或副主持并已完成国家自然科学基金项目“胃肠激素与脾失健运相关性及四君子汤调控机理研究(30771591)”、“热应激对猪小肠黏膜结构与功能的影响及其中药调控机制(30771566)”、“健脾消食中药对鸭胰腺外分泌的影响及其机理(30270977)”、“脏腑经穴磷酸二酯酶同功酶分布与中草药归经研究(30270978)”、“兽医中西药处方生成系统的研究(39270527)”等5项;北京市科委研发攻关类重大项目“畜禽抗应激冲剂的研制开发与推广”。

主要研究成果与获奖情况:获得授权国家发明专利9件:“一种用于治疗猪高热病的药物(200710175534.8)”、“大蒜挥发油在制备防治败血性波氏杆菌药物中的应用(200710117953.6)”、“一种用于提高畜禽生产性能的药物(200710175535.2)”、“一种用于防治宠物湿热下痢的药物(200710176869.1)”、“一种防治畜禽腹泻的中药及其制备方法(201310461884.6)”、“一种用于评价运输应激模型的基因芯片及其应用(201210439191.2)”、“评价脾虚证及中药药效的基因芯片(200910090825.6)”、“评价暑热证及中药药效的基因芯片(200910140954)”、“一种治疗畜禽呼吸道疾病的中药口服液(201310362943)”。“禽用保健型中兽药关键技术研究开发与应用”2014年获北京市科学技术奖贰等奖;“畜禽抗热应激等系列中药添加剂的应用研究与推广”2006年获得北京市农业技术推广奖贰等奖;“经穴实质与微血管的相关性研究”2008年获得北京市科学技术奖叁等奖;获得中国畜牧兽医学会荣誉奖、中国畜牧兽医学会先进个人奖、和“新中国60年畜牧兽医科技贡献奖(杰出人物)”。主讲的《中兽医学》被评为2010年度国家精品课程。

研究生培养:硕士生,已毕业31名,在读4名;博士生,已毕业14名,在读5名。

文章与编著:主编有《中兽医学》(面向21世纪全国高等院校统编教材)、《中兽医学》精简版(农业部“十二五”规划教材)、《中兽医方剂精华》、《猪病中药防治》和《创造新世纪中兽医学》;参加编写或翻译的著作有《中华兽医精典》、《中兽医方剂学》、《兽医中药药理学》、《中兽医学大辞典》、《现代中兽医大全》、《中兽医方剂大全》、《牛病中药防治》、《鸡病中药防治》、《中药饲料添加剂》、《伴侣动物疾病速查》、《动物医院临床技术》、《Chinese Anatomy and Physiology》、《Equine Acupuncture》、《Traditional Chinese Veterinary Acupuncture and Moxibustion》、《猪病学》等著作或教材20余本。在中外核心期刊发表论文120余篇,其中SCI论文20余篇。

代表性文章:

1 Liu M, Song S, Li H, Jiang X, Yin P, Wan C, Liu X, Liu F, Xu J: The protective effect of caffeic acid against inflammation injury of primary bovine mammary epithelial cells induced by lipopolysaccharide. J Dairy Sci 2014, 97:2856-2865. IF 2.566

2. Wan C, Yin P, Xu X, Liu M, He S, Song S, Liu F, Xu J: Effect of simulated transport stress on the rat small intestine: A morphological and gene expression study. Res Vet Sci 2014, 96:355-364. IF 1.774

3 Xu X, Yin P, Wan C, Chong X, Liu M, Cheng P, Chen J, Liu F, Xu J: Punicalagin inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4-mediated MAPKs and NF-kappaB activation. Inflammation 2014, 37:956-965. IF 2.457

4. Gao Z, Liu F, Yin P, Wan C, He S, Liu X, Zhao H, Liu T, Xu J, Guo S: Inhibition of heat-induced apoptosis in rat small intestine and IEC-6 cells through the AKT signaling pathway. BMC Vet Res 2013, 9:241. IF 1.86

5. Yu J, Liu F, Yin P, Zhao H, Luan W, Hou X, Zhong Y, Jia D, Zan J, Ma W, et al: Involvement of oxidative stress and mitogen-activated protein kinase signaling pathways in heat stress-induced injury in the rat small intestine. Stress 2013, 16:99-113. IF 3.4

6. Liu X, Li H, Lu A, Zhong Y, Hou X, Wang N, Jia D, Zan J, Zhao H, Xu J, Liu F: Reduction of intestinal mucosal immune function in heat-stressed rats and bacterial translocation. Int J Hyperthermia 2012, 28:756-765. IF 2.59

7. Hong Dong, Yougang Zhong, Fenghua Liu, Kai Yang, Jin Yu, Jianqin Xu. Regulating Effects and Mechanisms of Chinese Medicine Decoction on Growth and Gut Hormone Expression in Heat Stressed Pigs, Livestock Science, 2012, 143: 77-84. IF 1.294

8. Zhang NW, Guo SN, Li HR, Li JF, Xu XL, Wan CR, Zhao H, Liu FQ, Zan JL, Wang B, Xu JQ: Effects of Sijunzi Decoction on Small Intestinal T Lymphocyte Subsets Differentiation in Reserpine Induced Spleen Deficiency Rats, JOURNAL OF ANIMAL AND VETERINARY ADVANCES 2012,11: 1290-1298. IF 0.390

9 Nuowei Zhang, Jiefeng Li, Yanxin Hu, Guilin Cheng, Xiaoyu Zhu, Faqiang Liu, Yujie Zhang, Zhongjie Liu and Jianqin Xu. Effects of astragalus polysaccharide on the immune response to Foot-and-mouth disease vaccine in mice. Carbohydrate Polymers. 2010, 82: 680-686. IF 3.463

10. Li J, Zhong Y, Li H, Zhang N, Ma W, Cheng G, Liu F, Liu F, Xu J: Enhancement of Astragalus polysaccharide on the immune responses in pigs inoculated with foot-and-mouth disease virus vaccine. Int J Biol Macromol 2011, 49:362-368. IF 2.502

11. Zhu XY, Cheng GL, Liu FH, Yu J, Wang YJ, Yu TQ, Xu JQ, Wang M: Taguchi approach for anti-heat stress prescription compatibility in mice spleen lymphocytes in vitro. Arch Pharm Res 2011, 34:1125-1133. IF 1.588

12. Lu A, Wang H, Hou X, Li H, Cheng G, Wang N, Zhu X, Yu J, Luan W, Liu F, Xu J: Microarray analysis of gene expression profiles of rat small intestine in response to heat stress. J Biomol Screen 2011, 16:655-667. IF 2.5

13. Yu J, Liu FH, Yin P, Zhu XY, Cheng GL, Wang N, Lu A, Luan WL, Zhang NW, Li JF, et al: Integrating miRNA and mRNA expression profiles in response to heat stress-induced injury in rat small intestine. Functional & Integrative Genomics 2011, 11:203-213. IF 3.4

14. Anru Wang, Fenghua Liu, Zhepeng Wang, Xue Jiang Wei Wang, Kedao Teng, Jianqin Xu. Pathological Study of SPF Chickens Experimentally Infected with a Chinese IBDV Strain BC6/85. Asian Journal of Animal and Veterinary Advances, 2011. IF 0.2349

15. Chen X, Xu J, Mu X, Hu Y, Hu G, Duan H, Zhang T, Lin H, Zhang W: Effects of rhynchophylline and isorhynchophylline on nitric oxide and endothelin-1 secretion from RIMECs induced by Listeriolysin O in vitro. Vet Microbiol 2010, 143:262-269. IF 3.256

16. Yu J, Yin P, Liu F, Cheng G, Guo K, Lu A, Zhu X, Luan W, Xu J: Effect of heat stress on the porcine small intestine: a morphological and gene expression study. Comp Biochem Physiol A Mol Integr Physiol 2010, 156:119-128. IF 2.196

17. Yu J, Yin P, Yin J, Liu F, Zhu X, Cheng G, Guo K, Yin Y, Xu J: Involvement of ERK1/2 signalling and growth-related molecules' expression in response to heat stress-induced damage in rat jejunum and IEC-6 cells. Int J Hyperthermia 2010, 26:538-555. IF 2.928

18. Song XZ, Xu JQ, Wang T, Liu FH: Traditional Chinese medicine decoction enhances growth performance and intestinal glucose absorption in heat stressed pigs by up-regulating the expressions of SGLT1 and GLUT2 mRNA. LIVESTOCK SCIENCE 2010,128: 75-81 IF 1.295

19. Liu F, Yin J, Du M, Yan P, Xu J, Zhu X, Yu J: Heat-stress-induced damage to porcine small intestinal epithelium associated with downregulation of epithelial growth factor signaling. J Anim Sci 2009, 87:1941-1949. IF 2.466

20. Song XZ, Xu JQ, Wang T, Liu F: Chinese Medicine Granule Affects the Absorption and Transport of Glucose in Porcine Small Intestinal Brush Border Membrane Vesicles under Heat.ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL. FEB 2009, 22: 246-253. IF 0.487

21. Gu JN, Chen W, Yu TQ, Lu P, Mu X, Xu JQ: Detection of cyclic nucleotide phosphodiesterase mRNA in mouse skeletal muscle tissue and primary cultured myocytes. JOURNAL OF ANIMAL AND FEED SCIENCES 2007, 16: 696-705. IF 0.305

22. Su D, Li XB, Wang ZJ, Wang L, Wu WX, Xu JQ: Pharmacokinetics and bioavailability of imidocarb dipropionate in swine. J Vet Pharmacol Ther 2007, 30:366-370. IF 1.674

23. Duan HQ, Zhang YD, Xu JQ, Qiao J, Suo ZW, Hu G, Mu X: Effect of anemonin on NO, ET-1 and ICAM-1 production in rat intestinal microvascular endothelial cells. JOURNAL OF ETHNOPHARMACOLOGY, 2005, 104: 362-366. IF=2.049

 

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