
Rui Zhang, PhD
Associate Professor of Veterinary Biomedicine
Veterinary Biomedical Teaching and Research Group
2015001@cau.edu.cn
010-62733484
Education
09/2010-10/2014, PhD in Veterinary Microbiology, University of Saskachewan
09/2007-07/2010, MS in Veterinary Microbiology, China Agricultural University
09/2003-07/2007, B.Sc in Veterinary Medicine, Southwest University
Training and Professional Experience
2017-now, Associate Professor, Department of Veterinary Biomedicine, College of Veterinary Medicine, China Agricultural University
2015-2017, Lecturer and Research Assistant, Department of Veterinary Biomedicine, College of Veterinary Medicine, China Agricultural University
Research Interests
The research mainly focuses on the signal transduction and animal diseases, including: 1) herpes virus & host interaction, which mainly takes human and animal herpesviruses (HSV-1 and PRV) as models to identify the host innate immune signal molecules and to study the molecular mechanisms by which viruses escape host innate immune response. 2) comparative oncology and cell signal transduction, which takes multiple tumors of companion animals as models to conduct comparative medical research with human tumor diseases, focusing on the signal transduction and regulation pathways in tumorigenesis and development.
Teaching
2021-now, Undergraduate course "Cancer Cell Biology-Basics and Clinics"
2018-now, Undergraduate course "Animal Cell Biology"
2015-now, Undergraduate course "Veterinary Biotechnology"
2015-now, Graduate course "Experimental Techniques in Cell Biology"
Reviewer for
Journal of Veterinary Science
Cellular & Molecular Biology Letters
Anti-cancer Agents in Medical Chemistry
Selected Publications
Zhang R, Chen S, Zhang Y, Wang M, Qin C, Yu C, Zhang Y, Li Y, Chen L, Zhang X, *Yuan X, *Tang J. (2021). Pseudorabies Virus DNA Polymerase Processivity Factor UL42 Inhibits Type I Interferon Response by Preventing ISGF3-ISRE Interaction. Journal of Immunology. 207 (2) 613-625.
Yu C, Xu A, Lang Y, Qin C, Yuan X, Feng W, Wang M, Gao C, Chen J, *Zhang R and *Tang J. (2020). Swine Promyelocytic Leukemia Isoform II Inhibits Pseudorabies Virus Infection by Suppressing Viral Gene Transcription in PML-NBs. Journal of Virology. doi.org/10.1101/2020.03.23.004697. (IF=4.51)
*Zhang R, Cui D, Xue T, Lang Y, Li, Sun H, Kuang Y, Li G and *Tang J. (2020). HLA-B-associated transcript 3 (Bat3) stabilizes and activates p53 in a HAUSP-dependent manner. Journal of Molecular Cell Biology. 12(2):99-112.
#Wang W, #Zhang R, Wang J, Tang J, Wang M, *Kuang Y. (2020). Antitumor Activity of Muricatacin Isomers and Its Derivatives in Human Colorectal Carcinoma Cell HCT116. Anticancer Agents Med Chem. 20:254-263.
Dong H,* Zhang R,* Kuang Y,* Wang X. (2020). Selective regulation in ribosome biogenesis and protein production for efficient viral translation. Archives of Microbiology. DOI 10.1007/s00203-020-02094-5.
Qin C, Zhang R, Lang Y, Shao A, Xu A, Feng W, Han J, Wang M, He W, Yu C, Tang J. (2019). Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3. PLoS Pathog. 15(1):e1007559.
Zhang R, Xu A, Qin C, Zhang Q, Chen S, Lang Y, Wang M, Li C, Feng W, Zhang R, Jiang Z, *Tang J. (2017). Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response. J Virol. 91: e01148-17.
Wang Z, Hou X, Wang Y, Xu A, Cao W, Liao M,* Zhang R,* Tang J. (2017). Ubiquitination of non-lysine residues in the retroviral integrase. Biochem Biophys Res Commun. 494:57-62. (IF=2.466)
Zhang R, Thamm DH, Misra V. (2015). The effect of Zhangfei/CREBZF on cell growth, differentiation, apoptosis, migration, and the UPR in several canine osteosarcoma cell lines. BMC Vet Res 10.1186/s12917-015.
Zhang R, Misra V. (2014). Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53. Cell cycle 13: 279-292.
Ying Z, Zhang R, Verge VM, Misra V. (2015). Cloning and characterization of rat Luman/CREB3, a transcription factor highly expressed in nervous system tissue. J Mol Neurosci. 55:347-354.
Zhang R, Rapin N, Ying Z, Shklanka E, Bodnarchuk TW, Verge VMK, Misra V. (2013). Zhangfei/CREB-ZF - A Potential Regulator of the Unfolded protein Response. PLoS One 8: e77256.