Zhanhui Wang

Education

• 09/2002-06/2007, Ph.D. Degree, College of Veterinary Medicine, China Agricultural University

• 09/1998-06/2002, B.Sc. Degree, College of Veterinary Medicine, Nanjing Agricultural University

Training and Professional Experience

• 2016-present, Professor (Full) China Agricultural University, College of Veterinary Medicine

• 2010-2015, Professor (Associate) China Agricultural University, College of Veterinary Medicine

• 2007-2019, Professor (Assistant) China Agricultural University, College of Veterinary Medicine

Research Interests

• Rational design and synthesis Chemical contaminant hapten, investigation the relationship between hapten characterization and generation of antibody in host animal.

• Production of biotical recognition macromolecule to small molecule, mainly antibody and also recombinant antibody, receptor, aptamer, peptide, etc.

• Molecular Interaction of hapten and antibody and in vitro evoluation of antibody performance by both in silicon and experimental techniques, such as directed mutation.

• Development of novel immunochemical methods and prodcuts based one new materials such as fluorescent polarization immunoassay (FPIA), immunochromatographic assay (ICA).

Awards and Honors

• 2019, Leading talents of scientific and technological innovation in the national "ten thousand talents plan"

• 2016, National Natural Science Foundation--Outstanding Youth Foundation2015, Second Class Prizes of National award for technological invention

• 2013, First Class Prize of China Agricultural Science and Technology Award

• 2012, Winner of Education Ministry's New Century Excellent Talents Supporting Plan

• 2009, National Excellent Doctoral Dissertation Award nomination

• 2008, Beijing Excellent Doctoral Dissertation

Teaching

• Pharmaceutical Chemistry for undergraduate

• Rapid detection technology of veterinary drug residues for master student

Editor broad member for

• Journal of Agricultural and Food Chemistry

• Food Agricultural Immunology

• Sensors

• Biomolecules

• Journal of food safety and quality inspection

Service

• 2016-Now, Deputy Secretary General of food quality and safety testing instruments and technology application branch of China instrumentation Society

• 2016-Now, Deputy director of Beijing International Science and technology cooperation base for risk assessment of hazardous compounds

• 2015-Now, Deputy director of Beijing Key Laboratory of animal derived food safety detection technology

• Executive director of Veterinary Pharmacology and toxicology branch of China animal husbandry and Veterinary Society

• Member of the expert group in the field of food and drug safety of the Ministry of science and technology

Selected Publications

• Chenglong Li, Huijuan Yang, Wenbo Yu, Xuezhi Yu, Kai Wen, Jianzhong Shen, Zhanhui Wang*. Engineering of organic solvent-tolerant antibody to sulfonamides by CDR grafting for analytical purposes. Analytical Chemistry, 2021, 93, 6008-6012.

• Yuchen Bai, Hui Jiang, Yingjie Zhang, Leina Dou, Minggang Liu, Wenbo Yu, Kai Wen, Jianzhong Shen, Yuebin Ke, Xuezhi Yu, Zhanhui Wang*. Hydrophobic moiety of capsaicins hapten enhancing antibody performance in immunoassay: evidences from computational chemistry and molecular recognition. Journal of Agricultural and Food Chemistry, 2021, 69, 34, 9957–9967.

• Ghulam Mujtaba Mari, Hongfang Li, Baolei Dong, Huijuan Yang, Aisha Talpur, Jiafei Mi, Liuchuan Guo, Xuezhi Yu, Yuebin Ke, Dianggang Han, Zhanhui Wang*. Hapten synthesis, monoclonal antibody production and immunoassay development for direct detection of 4-hydroxybenzehydrazide in chicken, the metabolite of nifuroxazide. Food Chemistry, 2021, 355, 129598.

• Baolei Dong#, Hongfang Li#, Jiefang Sun, Yuan Li, Ghulam Mujtaba Mari, Xuezhi Yu, Wenbo Yu, Kai Wen, Jianzhong Shen*, Zhanhui Wang*. Magnetic and cost-effective fluorescent immunoassay for sensitive chloramphenicol detection based on the carbon dots-encapsulated calcium carbonate nanocomposites. Journal of Hazardous Materials, 2021, 402, 12394.

• Hongfang Li, Baolei Dong, Huiyan Zhang, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Kai Wen, Zhanhui Wang*. Fluorescent lateral flow immunoassay for the highly sensitive detection of eight anticoagulant rodenticides based on cadmium–free quantum dot–encapsulated nanospheres, Sensors and Actuators B: Chemical, 2020.

• Ling Yang, Xiya Zhang, Dongshuai Shen, Xuezhi Yu, Yuan Li, Kai Wen, Jianzhong Shen, Zhanhui Wang*. Hapten synthesis and antibody to fluoroacetamide, a super-small and high-toxic chemical. Biomolecules, 2020, 10, 986.

• Hongfang Li, Kai Wen, Baolei Dong, Jing Zhang, Yuchen Bai, Minggang Liu, Peipei Li, Mari Ghulam Mujtaba, Xiya Zhang, Xuezhi Yu, Wenbo Yu, Yuebin Ke, Jianzhong Shen, Zhanhui Wang*. Novel inner filter effect-based fluorescence immunoassay with gold nanoclusters for bromadiolone detection in human serum. Sensors and Actuators B: Chemical, 2019, 297, 126787.

• Huiyan Zhang, Karl De Ruyck, Natalia Beloglazova*, Shupeng Yang, Sergei A. Eremin, Sarah De Saeger, Suxia Zhang, Jianzhong Shen, Zhanhui Wang*. Fluorescence polarization assay for chemical contaminants in food and environmental analysis. Trend in Analytical Chemistry, 2019, 114, 293–313.

• Chenglong Li, Xiao Liang, Kai Wen, Yonghan Li, Xiya Zhang, Mingfang Ma, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Zhanhui Wang*. Class-specific monoclonal antibodies and dihydropteroate synthase in bioassays used for the detection of sulfonamides: structural insights into recognition diversity. Analytical Chemistry, 2019, 91, 2392–2400.

• Ling Yang, Hengjia Ni, Suxia Zhang, Ghulam Mujtaba Mari, Yuebin Ke, Kai Wen, Huijuan Yang, Weimin Shi, Jianzhong Shen, Zhanhui Wang*. Development of a highly specific chemiluminescence aptasensor for sulfamethazine detection in milk based on in vitro selected aptamers. Sensors and Actuators B: Chemical, 2019, 271, 801–811.

• Baolei Dong, Sijun Zhao, Hongfang Li, Kai Wen, Jianzhong Shen, Suxia Zhang, Weimin Shi, Zhanhui Wang*. Design, synthesis and characterization of tracers and development of a fluorescence polarization immunoassay for the rapid detection of ractopamine in pork. Food Chemistry, 2019, 271, 9–17.

• Xiao Liang, Chenglong Li, Xiaoli Song, Suxia Zhang, Jing Zhang, Qidi Zhang, Jianzhong Shen, Zhanhui Wang*. Dihydropteroate synthase based sensor for screening multi-sulfonamides residue and its comparison with broad-specific antibody based immunoassay by molecular modeling analysis, Analytica Chimica Acta, 2019, 1050, 139–145.

• Hongfang Li, Shaoqin Ma, Xiya Zhang, Chenglong Li, Baolei Dong, Mari Ghulam Mujtaba, Yujie Wei, Xuezhi Yu, Kai Wen, Wenbo Yu, Jianzhong Shen, Zhanhui Wang*. Generic haptens synthesis, broad-specific monoclonal antibodies preparation and ultrasensitive ELISA for five antibacterial synergists in chicken and milk. Journal of Agricultural and Food Chemistry, 2018, 66:10931–11196.

• Chaochao Chen, Jiaxun Luo, Chenglong Li, Mingfang Ma, Wenbo Yu, Jianzhong Shen. Zhanhui Wang*. Molecularly imprinted polymer as an antibody substitution in pseudo-immunoassays for chemical contaminants in food and environmental samples. Journal of Agricultural and Food Chemistry, 2018, 66, 2561–2571.