个人简介

动物医学院副院长、教授、博士生导师，校引进“拔尖人才”。2000年本科毕业于中国农业大学动物医学院兽医专业，2003年获中国农业大学预防兽医学硕士学位，2008获美国明尼苏达大学动物病毒学方向博士学位，之后进入宾夕法尼亚州立大学医学院进行博士后训练，并于2014年获美国宾夕法尼亚州立大学医学院杰出博士后奖以及NIH K99基金。2015年起, 受聘于中国农业大学动物医学院。目前承担的科研任务包括国家自然科学基金项目、国家973计划课题子任务、中国农业大学启动基金，以及国家十三五计划子任务等。主要研究成果以第一作者或通讯作者的文章发表于在PNAS, Journal of Virology等杂志，并获得国际专利1项。 担任Journal of Virology, Virology, Virus Research, Virology, Archives of Virology, Veterinary Microbiology等国际期刊的同行评审人。研究兴趣主要集中在猪重要病毒性病原(PRRSV, PEDV,HSV)的复制和致病机理。教学上，主讲研究生课程 “Science of Virology”，参讲研究生课程“预防兽医Seminar” 和 “兽医科学进展”，本科生课程 “兽医微生物实验”, 以及中国农科院研究生院“高级动物分子病毒学”。

教育背景

09/2003-12/2008   博士，美国明尼苏达大学，动物病毒学

09/2000-07/2003   硕士，中国农业大学，兽医微生物

09/1996-07/2000   本科，中国农业大学, 兽医

工作经历

03/2015-现在     教授，中国农业大学动物医学院预防兽医系

01/2009-02/2015  博士后，美国宾夕法尼亚州立大学医学院

获奖及荣誉

2014  美国宾夕法尼亚州立大学医学院杰出博士后奖

2014  NIH K99 award

教学工作

2016-现在 参讲本科生课程“兽医微生物”

2015-现在 参讲博士研究生课程“预防兽医Seminar”

2015-现在 参讲博士研究生课程“兽医科学进展”

2015-现在 主讲研究生课程“Science of Virology”

研究兴趣

以猪的重要病毒性病原PRRSV和PEDV，以及人单纯疱疹病毒 (HSV-1)等为研究对象，研究病毒的复制、感染、传播和和致病机理。

在研项目

1.国家自然科学基金面上项目,非结构蛋白nsp2调控PRRSV亚基因组转录复制的分子基础，2015.1-2018.12, 88万元，在研，主持。

2.中国农业大学人才引进启动基金，2016-2018，100万元，主持

3.PRRSV诱导宿主免疫抑制及拮抗宿主免疫信号转导蛋白的筛选及分子机制， 2014-2018，80万，在研，主持。

4.“PEDV毒力因子的鉴定”，十三五国家重点研发计划，2017-20120，180万，主持

5.国家自然科学基金面上项目,人单纯疱疹病毒囊膜糖蛋白gI曲膜特性的分子机制以及生物学意义，2018.1-2021.12,65万元，在研，主持

代表性文章

1.Peng Gao, Yue Chai, Jiangwei Song, Teng Liu, Peng Chen, Lei Zhou, Xinna Ge, Xin Guo, Jun Han*, Hanchun Yang. 2019. Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus. PLOS Pathogens. Nov 18. 15(11):e1008169. doi: 10.1371/journal. ppat. 1008169. [Epub ahead of print].  *通讯作者

2.Shao Chuanzhou, Xinna Ge, Can Kong, Lei Zhou, Xin Guo, Jun Han*, Hanchun Yang. 2019. Characterization of the PRRSV nsp2 deubiquitinase reveals dispensability of cis-activity for replication and a strong link of nsp2 to inflammation induction. Viruses. 11(10), 896.

3.Jiangwei Song, Peng Gao, Yunhao Hu, Yue Chai, Lei Zhou, Xinna Ge, Xin Guo, Jun Han*, Hanchun Yang. 2019. The nsp2 replicase protein of porcine reproductive and respiratory syndrome virus is associated with tissue tropism to primary porcine alveolar macrophages. Journal of Virology. Sep 25. pii: JVI.01436-19. doi: 10.1128/JVI.01436-19. [Epub ahead of print].

4.Jiangwei Song, Yuanyuan Liu, Peng Gao, Yunhao Hu, Yue Chai, Shaochuan Zhou, Can Kong, Lei Zhou, Xinna Ge, Xin Guo, Jun Han*, Hanchun Yang. 2018. Mapping the nonstructural protein interaction network of porcine reproductive and respiratory syndrome virus. Journal of Virology. Pii: JVI.01112-18. (JVI spotlight article)

5.Jillian Carmichael, Jason Starkey, Dan Zhang, Akua Sarfo, Pooja Chadha, John W Wills, and Jun Han*. 2018. Glycoprotein D of HSV-1 is dependent on tegument protein UL16 for packaging and contains a motif that is differentially required for syncytia formation. Virology. 527: 64-76.

6.Di Wang, Xinna Ge, Dongjie Chen, Jie Li, Yueqi Cai, Jin Deng, Lei Zhou, Xin Guo, Jun Han*, Hanchun Yang*. 2018. The S Gene Is Necessary but Not Sufficient for the Virulence of Porcine Epidemic Diarrhea Virus Novel Variant Strain BJ2011C. Journal of Virology. 92 (13): e00603-18. 

7.Yuanyuan Liu, Yuhao Hu, Yue Chai, Liping Liu, Jiangwei Song, Shaochuan Zhou, Jia Su, Lei Zhou, Xinna Ge, Xin Guo, Jun Han* and Hanchun Yang*. 2018. Identification of Nonstructural Protein 8 as the N-Terminus of the RNA-Dependent RNA Polymerase of Porcine Reproductive and Respiratory Syndrome Virus. Virol Sin. 3(5):429-439.

8.Jie Li，Zhonghui Jin，Yueyi Gao，Lei Zhou，Xinna Ge，Xin Guo，Jun Han* and Hanchun Yang*. 2017. Development of the full-length cDNA clones of two porcine epidemic diarrhea disease virus isolates with different virulence. PLos One.  Mar 16;12(3):e0173998. doi: 10.1371/journal.pone.0173998.

9.Jun Han#, Lei Zhou#, Xinna Ge, Xin Guo and Hanchun Yang. 2017. Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus. Veterinary Microbiology. pii: S0378-1135(16) 30512-0. doi: 10.1016/j.vetmic.2017.02.0202017.03.02

10.Jige Du., Xinna Ge, Ying Liu，Ping Jiang, Zhe Wang, Ruimin Zhang, Lei  Zhou, Xin Guo, Jun Han* and Hanchun Yang*. 2016. Targeting Swine Leukocyte Antigen Class I Molecules for Proteasomal Degradation by the nsp1α Replicase Protein of the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Strain JXwn06. Journal of Virology. 90(2):682-693.

11.Jun Han, Pooja Chadha, Jason L. Starkey and John Wills. 2012. Function of glycoprotein E of herpes simplex virus requires coordinated assembly of three tegument proteins on its cytoplasmic tail. Proc Natl Acad Sci USA. 109 (48): 19798-803.

12.Pei-Jun Yeh#, Jun Han#, Pooja Chadha#, David G. Meckes, Jr., Michael D. Ward, O. John Semmes, and John W. Wills. 2011. Direct and Specific Binding of the UL16 Tegument Protein of Herpes Simplex Virus to the Cytoplasmic Tail of Glycoprotein E. Journal of Virology. 85: 9425-36.

13.Jun Han, Pooja Chadha, David Meckes. Jr., Nicholas Baird, and John W. Wills. 2011. Interaction and Inter-Dependent Packaging of the Herpes Simplex Virus Tegument Protein UL11 and Glycoprotein E. Journal of Virology. 85: 9437-46.

14.Jun Han, Mark S. Rutherford, and Kay S. Faaberg. 2010. Proteolytic Products of the Porcine Reproductive and Respiratory Syndrome Virus Nsp2 Replicase Protein. Journal of Virology. 84: 10102-12.

15.Jun Han, Mark S. Rutherford, and Kay S. Faaberg. 2009. Porcine Reproductive and Respiratory Syndrome Virus Nsp2 Cysteine Protease Domain Possesses Both Trans and Cis-cleavage activities. Journal of Virology. 83: 9449-63

16.Jun Han, Gongping Liu, Yue Wang, and Kay S. Faaberg. 2007. Identification of Nonessential Regions in the Nsp2 Replicase Protein of Porcine Reproductive and Respiratory Syndrome Virus for Replication in Cell Culture. Journal of Virology. 81: 9878-90.

17.Jun Han, Yue Wang, and Kay S. Faaberg. 2006. Complete Genome Analysis of RFLP 184 Isolates of Porcine Reproductive and Respiratory Syndrome Virus. Virus Research. 122:175-82.