动物医学院预防兽医学系教授,博士生导师,2018年校引进“杰出人才”。2009年12月在捷克国家科学院寄生虫学研究所获得细胞与分子寄生虫学方向的博士学位,随后在英国纽卡斯尔大学以玛丽居里学者(Marie Curie Intra-European Fellow)继续从事寄生虫学研究,于2013年6月在美国圣路易斯华盛顿大学从事重要人兽共患寄生原虫-弓形虫的细胞与分子生物学研究。龙博士从2005年至2017年底一直在具有重要国际影响的寄生虫学科研团队学习和工作,受到了严格的训练,以第一作者在Nature Communications、PLoS Pathogens、PNAS、Infection and Immunity、Molecular Microbiology等学术期刊发表多篇研究论文,并参与多项基础理论和药物开发相关的课题研究。近3年来,龙博士在弓形虫入侵宿主的细胞与分子机制、和弓形虫分子遗传研究技术方面取得了系列的重要进展,对解析弓形虫的生物学和致病机制具有直接的推动作用。龙博士的研究方向将包括以下几个方面:以重要人兽共患寄生原虫-弓形虫为研究模型,深入探讨重要原虫的入侵/逸出机制、原虫与宿主的互作、原虫生活周期中虫体的发育与分化、以及重要原虫的防控措施等。 代表性文章: 1.Long S, Anthony B, Drewry L, Sibley LD. 2017. A Conserved ankyrin repeat containing protein CPH1 regulates conoid stability, motility and cell invasion in Toxoplasma. Nature Communications. 2017.12.21,8(1). 影响因子=12.124 2.Long S; Brown KM; Drewry LL; Anthony B; Phan IQ; Sibley LD. 2017. Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii. PLoS Pathogens. 2017.5.5, 13(5):e1006379. F1000 recommendations - Microbiology. 影响因子=6.608 3.Long S, Wang Qiuling, Sibley David. 2016. Analysis of noncanonical calcium-dependent protein kinases in Toxoplasma gondii by targeted gene deletion using CRISPR/Cas9. Infection and Immunity. 2016.4.22. 84(5):1262-73. 5年影响因子=3.593 Commentary: Bzik DJ. 2016. Serial Dissection of Parasite Gene Families. Infect Immun. 84(5):1252-4. Doi:10.1128/IAI.00175-16. 4.Long S, Brown KM, Sibley LD. 2018. Protein interactomes defined by BirA labeling in Toxoplasma gondii. Bio-Protocol. 8(6). pii: e2768. 5.Brown KM, Long S, Sibley LD. 2018. Conditional Knockdown of Proteins Using Auxin-inducible Degron (AID) Fusions in Toxoplasma gondii. Bio-Protocol. 2018.2.20, 8(4). 6.Long S, Jirků M, Ayala FJ, Lukeš J. 2008. Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei. Proc. Natl. Acad. Sci. USA. 2008.9.9, 105: 13468-13473. 影响因子=9.661 7.Long S, Jirků M, Mach J, Ginger ML, Sutak R, Des Richardson R, Tachezy J, Lukeš J. 2008. Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes. Mol. Microbiol. 2008.7, 69: 94-109. 影响因子=3.898 8.Long S, Piya C, Tsaousis DA, Skalicky T, Verner Z, Wen YZ, Roger AJ, Lukeš J. 2011. Stage-specific essentiality of Isa1 and Isa2, mitochondrial Fe/S cluster assembly proteins in the excavate protist Trypanosoma brucei. Mol. Microbiol. 2011.9, 81: 1403-1418. 影响因子=3.898 9.Long S, Vavrova Z, Lukeš J. 2008. The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei. Mol. Biochem. Parasitol. 2008.11, 162: 100-104. 影响因子=2.536 合作作者论文: 10.Molik S, Goldberg AV, Hacker C, Freibert SA, Dean P, Williams TA, Nakjang S, Long S, Sendra K, Heinz E, Hirt RP, Lucocq JM, Embley TM, Lill R. 2017. Evolutionary conservation and in vitro reconstitution of microsporidian iron-sulfur cluster biosynthesis. Nature Communications. 2017.1.4, 8:13932. 影响因子=12.124 11.Rutaganira F, Barks J, Dhason M, Wang Q, Lopez M, Long S, Radke J, Jones N, Maddirala A, Janetka J, El Bakkouri M, Hui R, Shokat K, Sibley LD. 2017. Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii. J Med Chem. 2017.12.28. 60(24):9976-9989. 影响因子=6.259 12.Brown K, Long S, Sibley LD. 2017. Plasma membrane-association by N-acylation governs PKG function in Toxoplasma gondii. mBio. 2017.5.2, 8(3):e00375-17. 影响因子=6.956 13.Kuhlenschmidt TB, Rutaganira FU, Long S, Tang K, Shokat KM, Kuhlenschmidt MS, Sibley LD. 2015. Inhibition of calcium-dependent protein kinase 1 (CDPK1) in vitro pyrazolopyrimidine derivatives does not correlate with sensitivity of Cryptosporidium parvum growth in cell culture. Antimicrob Agents Chemother. 2015.11.9. 60(1):570-9. 影响因子=4.302 14.Piya C, Horáková E, Long S, Černotíková-Stříbrná E, Lindsay M. Esteban JM. Bontempi, Lukeš J. 2013. Both human ferredoxins equally efficiently rescue ferredoxin deficiency in trypanosomes. Mol. Microbiol. 2013.7, 89: 135-51. 影响因子=3.898 15.Tsaousis AD., Ollagnier-de Choudens S, Gentekaki E, Long S, Gaston D, Stechmann A, Vinella D, Py B, Fontecave M, Barras F, Lukeš J and Roger AJ. 2012. The evolution of Fe-S cluster biogenesis in the anaerobic parasite Blastocystis. Proc. Natl. Acad. Sci. USA. 2012.6.26,109: 10426-10431. 影响因子=9.661 16.Bang S, Brown L, Long S, Sibley LD. 2017. Development of CRISPR/Cas9 for efficient genome editing in Toxoplasma gondii. Methods in Molecular and Cellular Biology. 1498:79-103. 17.Týč J, Long S, Jirků M, Lukeš J. 2010. YCF45 protein, usually associated with plastids, is targeted into the mitochondrion of Trypanosoma brucei. Mol. Biochem. Parasitol. 173: 43-47. 影响因子=2.157 18.Wohlgamuth-Benedum JM, Rubio MT, Paris Z, Long S, Poliak P, Lukeš J, Alfonzo JD. 2009. Thiolation controls cytoplasmic tRNA stability and acts as a negative determinant for tRNA editing in mitochondria. J. Biol. Chem. 284: 23947-23953. 影响因子=4.323 |