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PRRSV NADC30-like viruses in the United States
Investigations into the role of nonstructural protein 2 (nsp2) in PRRSV pathogenesis

发布日期:2018-06-19访问次数: 信息来源:动物医学院字号:[ ]


报告人:Kay S. Faaberg, PH.D., Professor
USDA National Animal Disease Center (美国农业部动物疫病中心)
报告题目:
1. PRRSV NADC30-like viruses in the United States
2.·Investigations into the role of nonstructural protein 2 (nsp2) in PRRSV pathogenesis.
时间:2018年6月19日(周二),上午: 9:00-11:30
地点:动医动科大楼401
联系人:韩军 
电话:62733962
报告人简介
Kay S. Faaberg, Professor of Virology
Dr. Faaberg is a virologist at the USDA national animal disease center(NADC). Prior to that, she was a faculty member in the Department of Veterinary and Biomedical Sciences at the University of Minnesota-Twin Cities while also serving as section head of Molecular Diagnostics of the University of Minnesota Veterinary Diagnostic Laboratory (VDL). Her lab mainly focuses on the molecular biology and pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV), the most devastating virus to the worldwide swine industry. Her lab has made many pioneering studies on a variety of aspects of PRRSV, including the first description of North American prototype VR-2332, discovery of PRRSV recombination and evolution, identification of PRRSV defective RNAs, development of the first infectious cDNA clone for type II PRRSV, and the report of the emergence of PRRSV MN184 strains and the derivative NADC30 strains. Her seminal work also includes the dissection of the biological functions of PRRSV nsp2 in in virus replication and pathogenesis. 
Selective publications:
1. Nelsen, C. J., M. P. Murtaugh, and K. S. Faaberg. 1999. Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents. J Virol 73:270-280.
2. Yuan, S., M. P. Murtaugh, and K. S. Faaberg. 2000. Heteroclite subgenomic RNAs are produced in porcine reproductive and respiratory syndrome virus infection. Virology 275:158-169.
3. Nielsen, H. S., G. Liu, J. Nielsen, M. B. Oleksiewicz, A. Botner, T. Storgaard, and K. S. Faaberg. 2003. Generation of an infectious clone of VR-2332, a highly virulent North American-type isolate of porcine reproductive and respiratory syndrome virus. J Virol 77:3702-3711.
4. Ropp, S. L., C. E. Wees, Y. Fang, E. A. Nelson, K. D. Rossow, M. Bien, B. Arndt, S. Preszler, P. Steen, J. Christopher-Hennings, J. E. Collins, D. A. Benfield, and K. S. Faaberg. 2004. Characterization of emerging European-like porcine reproductive and respiratory syndrome virus isolates in the United States. J Virol 78:3684-3703.
5. Han, J., Liu, G., Liu, H., Wang, Y., Roof, M. B. Vaughn, E. M., Burkhart, K. M., and K. S. Faaberg. 2007. Identification of nonessential regions for viral replication in the nsp2 replicase protein of porcine reproductive and respiratory syndrome virus strain VR-2332 in cell culture. J. Virol, 81:9878-9890.
6. Han, J., Rutherford, M. S., and K. S. Faaberg. 2009. Porcine reproductive and respiratory syndrome virus nsp2 cysteine protease domain possesses both trans- and cis-cleavage activities. J. Virol. 83:9449-9463.
7. Han, J., M. S. Rutherford, and K. S. Faaberg. 2010. Proteolytic products of the porcine reproductive and respiratory syndrome virus nsp2 replicase protein. J. Virol. 84:10102-10112.
8. Guo, B., Lager, K.M., Henningson, J.N., Miller, L.C., Schlink, S.N., Kappes, M.A., Kehrli, Jr., M.E., Brockmeier, S.L., Nicholson, T. L., Loving, C.L., Yang, H.-C., and K.S. Faaberg. 2013. Infection of United States Swine with a Chinese Highly Pathogenic Strain of Porcine Reproductive and Respiratory Syndrome Virus. Virology 435:372-384.
9. Kappes, M. A., Miller, C. L. and K. S. Faaberg. 2013. Highly divergent strains of porcine reproductive and respiratory syndrome virus incorporate multiple isoforms of nonstructural protein 2 into virions. J. Virol. 87:13456-13465.
10. Kappes, M. A., Miller, C. L., and K. S. Faaberg. 2015. Porcine reproductive and respiratory syndrome virus nonstructural protein 2 (nsp2) topology and selective isoform integration in artificial membranes. Virology 481:51-62.
11. Kappes, M. A., and K. S. Faaberg. 2015. PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity. Virology 479-480:475-486.
12. Spear, A., Wang, F-X, Kappes, M.A, Das, P.B., and K. S. Faaberg. 2018. Progress to an Enhanced Vaccine: Eight Marked Attenuated Viruses to Porcine Reproductive and Respiratory Disease Virus. Virology 515, 30-37. 

 

 





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