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Genome evolution and host specificity in Cryptosporidium

发布日期:2018-04-10访问次数: 信息来源:动物医学院字号:[ ]


报告题目: Genome evolution and host specificity in Cryptosporidium

报告人:  肖立华 教授

报告地点: 动医动科大楼 401

报告时间: 411日(星期三)上午9: 00-10: 00

联系人:   教授

 

报告人简介: 肖立华,美国疾病预防控制中心前研究员(资深科学家),2012年美国寄生虫学会杰出成就奖(Henry Baldwin Ward Medal)获得者。长期从事重要人兽共患寄生虫,如隐孢子虫、贾第虫、微孢子虫的分类、分子流行病学、环境生态学等研究,开展了许多基础性、原创性和系统性的研究,取得了一些在国际上有影响的独创性成果。目前致力于:

Ÿ   Investigates the molecular and genomic epidemiology of zoonotic parasites in humans and animals in the context of One Health.

Ÿ   Genotypes and subtypes waterborne and foodborne protozoan pathogens (Cryptosporidium, Giardia, Cyclospora, Microsporidia, Naegleria fowleri) in clinical and environmental samples.

Ÿ   Tracks sources and spread of protozoan parasites using advanced molecular detection tools.

Ÿ   Develops and manages CryptoNet–CDC's first molecular surveillance system for a parasite–a DNA sequence-based system for understanding U.S. transmission of cryptosporidiosis.

 

部分研究论文:

[1]    Feng Y, Li N, Roellig DM, et al. Comparative genomic analysis of the IId subtype family of Cryptosporidium parvum [J]. Int J Parasitol, 2017, 47(5).

[2]    Liu S, Roellig DM, Guo Y, et al. Evolution of mitosome metabolism and invasion-related proteins in Cryptosporidium [J]. BMC Genomics, 2016, 17(1): 1006.

[3]    Liu S, Lin W, Zheng H, et al. Comparative genomics reveals Cyclospora cayetanensis possesses coccidia-like metabolism and invasion components but unique surface antigens [J]. BMC Genomics, 2016, 17(1): 316.

[4]    Guo Y, Roellig DM, Li N, et al. Multilocus Sequence Typing Tool for Cyclospora cayetanensis [J]. Emerging Infectious Diseases, 2016, 22(8): 1464-1467.

[5]    Guo Y, Tang K, Rowe LA, et al. Comparative genomic analysis reveals occurrence of genetic recombination in virulent Cryptosporidium hominis subtypes and telomeric gene duplications in Cryptosporidium parvum [J]. BMC Genomics, 2015, 16(1): 320.

[6]    Karim MR, Zhang S, Jian F, et al. Multilocus typing of Cryptosporidium spp. and Giardia duodenalis from non-human primates in China [J]. Int J Parasitol, 2014, 44(13): 1039-1047.

[7]    Wang Y, Yang W, Cama V, et al. Population genetics of Cryptosporidium meleagridis in humans and birds: evidence for cross-species transmission [J]. Int J Parasitol, 2014, 44(8): 515-521.

[8]    Li N, Xiao L, Alderisio K, et al. Subtyping Cryptosporidium ubiquitum,a Zoonotic Pathogen Emerging in Humans [J]. Emerging Infectious Diseases, 2014, 20(2): 217-224.

[9]    Feng Y, Torres E, Li N, et al. Population genetic characterisation of dominant Cryptosporidium parvum subtype IIaA15G2R1 [J]. Int J Parasitol, 2013, 43(14): 1141-1147.

[10]  Na L, Xiao L, Cama VA, et al. Genetic Recombination and Cryptosporidium hominis Virulent Subtype IbA10G2 [J]. Emerging Infectious Diseases, 2013, 19(10): 1573-1582.

 

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