教育背景： 09/2005-07/2010，北京大学生命科学学院，生物化学和分子生物学，理学博士学位，导师：郑晓峰，罗明 09/2000-07/2005，中国农业大学动物医学院，农学学士学位 科研经历： 04/2017 至今，中国农业大学动物医学院，副教授 01/2011-01/2016，普渡大学生物学院，结构病毒学，博士后研究员，导师：Michael G Rossmann 研究领域和方向： 结构生物学（X射线衍射晶体学和高分辨率冷冻电镜），病毒组装机制研究，基于结构的亚单位纳米颗粒疫苗设计，病毒免疫学研究，诊断抗原和抗体制备，快速诊断试剂研发。 专利： （1）孟赓（1/2），一种不同粒径超均匀球形纳米金颗粒制备方法，2020.8.6，中国，202010502481.1 （2）孟赓（1/4），一种非洲猪瘟免疫抗原及其制备方法和应用，2020.3.30, 中国, CN202010240109.8. 其他 . （3）孟赓（1/3），一种小反刍兽疫病毒抗原以及检测小反刍兽疫病毒抗体的胶体金免疫层析试纸卡，2019.12.16,中国，201911293190.X （4）孟赓（1/3），一种猪圆环病毒 II 型抗原以及检测猪圆环病毒 II 型抗体的胶体金免疫层析试纸条，2019.12.16,中国，201911294319.9 （5）孟赓（1/4），一种牛冠状病毒嵌合抗原以及检测牛冠状病毒抗体的胶体金免疫层析试纸卡，2019.12.16,中国，201911293235.3 （6）孟赓（1/4），一种牛轮状病毒嵌合抗原以及检测牛轮状病毒抗体的胶体金免疫层析试纸卡，2019.12.16,中国，201911293233.4 （7）孟赓（1/3），一种猪蓝耳病毒嵌合抗原以及检测猪蓝耳病毒抗体的胶体金免疫层析试纸条，2019.12.16,中国，201911300052.X （8）孟赓（1/4），一种非洲猪瘟病毒衣壳蛋白P72及其制备方法和应用，2021.05.13，中国，202110522777.4 代表性文章（#第一作者，*通讯作者）： 2021 1：Zhu, Zhenglin*; Liu, Gexin; Meng, Kaiwen; Yang, Liuqing; Liu, Di; Meng, Geng*. Rapid spread of mutant alleles in worldwide SARS-CoV-2 strains revealed by genome-wide single nucleotide polymorphism and variation analysis. Genome Biology and Evolution, 2021.（鉴定了系列流行的新冠病毒突变包括D614G，2020年4月16日即发表于预印版网站Research Square） 2020 1：Zhu Z*; Meng K; Meng G*. Genomic recombination events may reveal the evolution of coronavirus and the origin of SARS-CoV-2. Scientific Reports, 2020, 10(1): 0-21617. （报道了冠状病毒间存在的重组现象） 2：Zhu, Zhenglin*; Meng, Kaiwen; Liu, Gexin; Meng, Geng*. A database resource and online analysis tools for coronaviruses on a historical and global scale. Database（Oxford）, 2020. （搭建了冠状病毒基因组及蛋白组数据库） 3：Zhu ZhengLin*; Meng Geng*. ASFVdb: An integrative resource for genomic and proteomic analyses of African swine fever virus. Database（Oxford）, 2020, 1(14). （搭建了非洲猪瘟病毒基因组及蛋白组数据库） 4：Zhang, Lijie; Li, Xiaoying; Ma, Lizhen; Zhang, Bing; Meng, Geng*; Xia, Chun*. A Newly Recognized Pairing Mechanism of the alpha- and beta-Chains of the Chicken Peptide-MHC Class II Complex. The Journal of Immunology, 2020, 204(6): 1630-1640. （基于鸡MHC II的结构发现了一种新的alpha和beta链配对机制） 5：Chen, Chaochao; Yu, Xuezhi; Han, Diangang; Ai, Jun; Ke, Yuebin; Wang, Zhanhui*; Meng, Geng*. Non-CTAB synthesized gold nanorods-based immunochromatographic assay for dual color and on-site detection of aflatoxins and zearalenones in maize. Food Control, 2020, 118: 0-107418. （基于晶种法无CTAB制备金纳米棒的应用） 6：Zhu, Zhenglin*; Wang, Yawang; Zhou, Xichuan; Yang, Liuqing; Meng, Geng*; Zhang, Ze. SWAV: a web-based visualization browser for sliding window analysis. Scientific Reports, 2020, 10(1): 0-149. 7：Li, Zibin; Zhang, Nianzhi; Ma, Lizhen; Zhang, Lijie; Meng, Geng; Xia, Chun. The Mechanism of beta 2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish. ISCIENCE, 2020, 23(5): 0-UNSP 101119. 8：Zhang L.; Liu Y.; Meng G.; Liang R.; Zhang B.; Xia C*. Structural and Biophysical Insights into the TCRαβ Complex in Chickens. iScience, 2020, 23(12): 0-101828. 9：Ma, Lizhen; Zhang, Nianzhi; Qu, Zehui; Liang, Ruiying; Zhang, Lijie; Zhang, Bing; Meng, Geng; Dijkstra, Johannes M; Li, Shen; Xia, Max Chun*. A Glimpse of the Peptide Profile Presentation by Xenopus laevis MHC Class I: Crystal Structure of pXela-UAA Reveals a Distinct Peptide-Binding Groove. The Journal of Immunology, 2020, 204(1): 147-158. 2019 1：Qu, Zehui; Li, Zibin; Ma, Lizhen; Wei, Xiaohui; Zhang, Lijie; Liang, Ruiying; Meng, Geng; Zhang, Nianzhi*; Xia, Chun*. Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding. The Journal of Immunology, 2019, 202(12): 3493-3506. 2：Guo, Jingui; Xie, Yixiao; Yu, Zhu; Meng, Geng; Wu, Zhe*. Effect of Lactobacillus plantarum expressing multifunctional glycoside hydrolases on the characteristics of alfalfa silage. Applied Microbiology and Biotechnology, 2019, 103(19): 7983-7995. 3：孟凯闻; 朱文壮; 张迪; 金艺鹏; 林德贵; 孟赓*. 猫杯状病毒抗体间接ELISA检测方法的建立. 中国兽医杂志, 2019, (05): 36-39. 4：朱文壮; 刘轶群; 孟赓*. 纳米金颗粒的晶种法制备及表征. 中国兽医杂志, 2019, 55(10): 33-35+130. （基于晶种法制备的高均一性金纳米颗粒） 2018 1：孟凯闻; 孟赓; 林德贵; 张迪; 金艺鹏*. 猫杯状病毒研究进展. 中国兽医杂志, 2018, 54(4): 60-63+1. 2015 1：Yamamoto Takuya; Narpala Sandeep; Todd John Paul; Rao Srinivas S; McDermott Adrian B; Koup Richard A; Rossmann Michael G; Mascola John R; Graham Barney S; Cohen Jeffrey I*; Nabel Gary J*. Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site. Kanekiyo Masaru; Bu Wei; Joyce M Gordon; Meng Geng; Whittle James R R; Baxa Ulrich; Cell, 2015, 162(5): 1090-1100. 2：Liu Yue; Sheng Ju; Baggen Jim; Meng Geng; Xiao Chuan; Thibaut Hendrik J; van Kuppeveld Frank J M; Rossmann Michael G*. Sialic acid-dependent cell entry of human enterovirus D68. Nature Communications, 2015, 6: 0-8865. 3：Liu Yue; Sheng Ju; Fokine Andrei; Meng Geng; Shin Woong Hee; Long Feng; Kuhn Richard J; Kihara Daisuke; Rossmann Michael G*. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. Science, 2015, 347(6217): 71-74. 2014 1：Xiao Weichun#; Meng Geng#; Zhao Yanmei; Yuan Huihui; Li Tingting; Peng Yanyan; Zhao Yong; Luo Ming; Zhao Wenming; Li Zhanguo; Zheng Xiaofeng*. Human secreted stabilin-1-interacting chitinase-like protein aggravates the inflammation associated with rheumatoid arthritis and is a potential macrophage inflammatory regulator in rodents. Arthritis & Rheumatology, 2014, 66(5): 1141-1152. 2013 1：Wang Zhiqing; Li Long; Pennington Janice G; Sheng Ju; Yap Moh Lan; Plevka Pavel; Meng Geng; Sun Lei; Jiang Wen; Rossmann Michael G. Obstruction of dengue virus maturation by Fab fragments of the 2H2 antibody. Journal of Virology, 2013, 87(16): 8909-8915. 2：Liu Yong; Qin Kun; Meng Geng; Zhang Jinfang; Zhou Jianfang; Zhao Guangyu; Luo Ming; Zheng Xiaofeng*. Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus. Journal of Biological Chemistry, 2013, 288(16): 11013-11023. 3：Liu Yong; Meng Geng; Luo Ming; Zheng Xiaofeng. Crystallization and X-ray crystallographic analysis of the cap-binding domain of influenza A virus H1N1 polymerase subunit PB2. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013, 69(Pt 3): 280-283. 4：Geng Meng; Xiaojing An; Sheng Ye; Yong Liu; Wenzhuang Zhu; Rongguang Zhang; Xiaofeng Zheng*. The crystal structure of LidA, a translocated substrate of the Legionella pneumophila type IV secretion system. Protein & Cell, 2013, 4(12): 897-900 5：Meng Geng; Zhang Xinzheng; Plevka Pavel; Yu Qian; Tijssen Peter; Rossmann Michael G*. The structure and host entry of an invertebrate parvovirus. Journal of Virology, 2013, 87(23): 12523-12530. （基于昆虫细小病毒的结构的研究阐述了细小病毒破膜及基因组释放机制） 2012 1：Battisti Anthony J#; Meng Geng#; Winkler Dennis C; McGinnes Lori W; Plevka Pavel; Steven Alasdair C; Morrison Trudy G; Rossmann Michael G*. Structure and assembly of a paramyxovirus matrix protein. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(35): 13996-14000. （第一个副黏病毒分子组装模型的报道） 2：Bai Xiaoyun#; Meng Geng#; Luo Ming; Zheng Xiaofeng*. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules. Journal of Biological Chemistry, 2012, 287(26): 22387-22396. 3：Bai Xiaoyun; Meng Geng; Zheng Xiaofeng. Cloning, purification, crystallization and preliminary X-ray diffraction analysis of mouse PACSIN 3 protein. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012, 68(Pt 2): 159-162. 2011 1：Zhu Wenzhuang; Meng Geng; Liu Yong; Zhang Feiyun; Zheng Xiaofeng. Protein expression, crystallization and preliminary X-ray crystallographic studies of LidA from Legionella pneumophila. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011, 67(Pt 5): 637-639. 2：Ding Q.*; Meng G.; Wang S.-F.; Zheng X.-F.; Yang H.; Gong Q.-H. Ultrafast solvation dynamics of subtilisin-polyethylene glycol interaction for protein crystallization. Chinese Physics Letters, 2011, 28(6): 0-067804. 2010 1：Li Guoming; Qu Linglong; Meng Geng; Bai Xiaoyun; Dai Kesheng; Zheng Xiaofeng. Crystallization and preliminary X-ray crystallographic studies of human FAIM protein. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010, 66(Pt 8): 935-937. 2：Meng Geng; Zhao Yanmei; Bai Xiaoyun; Liu Yong; Green Todd J; Luo Ming; Zheng Xiaofeng*. Structure of human stabilin-1 interacting chitinase-like protein (SI-CLP) reveals a saccharide-binding cleft with lower sugar-binding selectivity. Journal of Biological Chemistry, 2010, 285(51): 39898-39904. 3：Bai Xiaoyun; Meng Geng; Li Guoming; Luo Ming; Zheng Xiaofeng. Crystallization and preliminary X-ray crystallographic analysis of human PACSIN 1 protein. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010, 66(Pt 1): 73-75. 2009 1：Dai Xueyu; Li Yiyu; Meng Geng; Yao Shun; Zhao Yanmei; Yu Quan; Zhang Jinfang; Luo Ming; Zheng Xiaofeng. NADPH is an allosteric regulator of HSCARG. Journal of Molecular Biology, 2009, 387(5): 1277-1285. 2：Li Guoming; Tang Zhenting; Meng Geng; Dai Kesheng; Zhao Jindong; Zheng Xiaofeng. Crystallization and preliminary X-ray crystallographic studies of O-methyltransferase from Anabaena PCC 7120. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009, 65(Pt 10): 1039-1041. 3：Meng Geng; Bai Xiaoyun; Green Todd J; Luo Ming; Zheng Xiaofeng*. Crystallization and preliminary X-ray crystallographic studies on SI-CLP, a novel human Glyco_18 domain-containing protein. Protein and Peptide Letters, 2009, 16(3): 336-338. 2008 1：Meng Geng; Zhai Ruitong; Liu Bin; Zheng Xiaofeng. Identification of a novel nuclear-localized adenylate kinase from Drosophila melanogaster. Biochemistry (Mosc), 2008, 73(1): 38-43. 2006 1：Zhai Ruitong#; Meng Geng#; Zhao Yanmei; Liu Bin; Zhang Genfa; Zheng Xiaofeng*. A novel nuclear-localized protein with special adenylate kinase properties from Caenorhabditis elegans. FEBS Letters, 2006, 580(16): 3811-3817. | 
