夏春,中国农业大学动物医学院教授、博士生导师。1982年毕业于华中农业大学(本科);1993年获日本爱媛大学博士学位;1995年完成于中国农业大学预防兽医学博士后研究并留校任教。1996年之后,先后在日本农林水产研究所免疫室、英国阿伯丁大学生命科学院、美国佐治亚医学院基因与蛋白质组研究中心进行过客座研究。研究方向是免疫学,主要聚焦于pMHC和IgSF的结构与功能及溯源,以及多表位疫苗的研发。主持过科技部“863”项目、国家转基因重大专项、国家自然科学基金重点项目、“973”项目(子课题PI)等项目共计17项。独立指导毕业博士、硕士、博士后、留学生约95名。承担了本院兽医生物技术与应用、兽医微生物学等相关教学任务。完成过国家自然基金委生命科学部各类项目评审,国家重点实验室项目评审,科技部项目评审与验收,教育部兽医学科论文抽查、评审;教育部科技奖励评审;中国兽药委员会新兽药评审专家。 作为主持人承担的主要科研项目: 1.鸡MHC-II表位肽识别与免疫调节机理的研究, 57万, 国家自然基金面上项目, 2020.01-2023.12; 2.鸡pMHCI-CD8复合体分子互作机制与抗病毒CTL免疫应答机理的研究, 76万, 国家自然基金面上项目, 2016.01-2019.12; 3.草鱼细胞毒性T细胞免疫应答的结构与功能基础及其调控机理研究, 310万, 国家自然科学基金重点项目, 2013.1-2017.12; 4.特异性免疫识别中结构与功能的演化, 215万, 科技部973, 2013.1-2017.12; 5.中国地方猪种优异特色性状的功能基因组学研究, 93.14万, 科技部863, 2013.1-2017.12; 6.免疫系统起源的亿年超前追溯, 254.5万, 科技部973, 2008.01-2012.12; 7.猪牛三类病毒强限制性MHC I基因克隆及其抗病功能验证, 286万, 国家转基因重大专项, 2009.01-2010.12; 8.石斑鱼分子免疫系统及其免疫应答机理的系统研究, 115万, 国家自然科学基金重点项目, 2007.01-2010.12; 9.海水鱼类复合长效干扰素关键技术的研究, 94万, 科技部863, 2008.01-2010.12; 10.四聚体技术鉴定鸡重要病毒抗原表位的研究, 35万, 国家自然科学基金面上项目, 2007.01-2009.12. 近年主要发表论文 1. Li, Z., N. Zhang, L. Ma, L. Zhang, G. Meng, and C. Xia*. 2020. The Mechanism of beta2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish. iScience 23: 101119. 2. Zhang, L., X. Li, L. Ma, B. Zhang, G. Meng*, and C. Xia*. 2020. A Newly Recognized Pairing Mechanism of the alpha- and beta-Chains of the Chicken Peptide-MHC Class II Complex. Journal of Immunology 204: 1630-1640. 3. Li, X., L. Zhang, Y. Liu, L. Ma, N. Zhang, and C. Xia*. 2020. Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope. The Journal of Biological Chemistry 295: 5292-5306. 4. Ma, L., N. Zhang, Z. Qu, R. Liang, L. Zhang, B. Zhang, G. Meng, J. M. Dijkstra, S. Li, and M. C. Xia*. 2020. A Glimpse of the Peptide Profile Presentation by Xenopus laevis MHC Class I: Crystal Structure of pXela-UAA Reveals a Distinct Peptide-Binding Groove. Journal of Immunology, 204: 147-158. 5. Qu, Z., Z. Li, L. Ma, X. Wei, L. Zhang, R. Liang, G. Meng, N. Zhang*, and C. Xia*. 2019. Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding. Journal of Immunology 202: 3493-3506.(封面论文) 6. Chen, R., L. Zhang, J. Qi, N. Zhang, L. Zhang, S. Yao, Y. Wu, B. Jiang, Z. Wang, H. Yuan, Q. Zhang, and C. Xia*. 2018. Discovery and Analysis of Invertebrate IgVJ-C2 Structure from Amphioxus Provides Insight into the Evolution of the Ig Superfamily. Journal of Immunology 200: 2869-2881. (封面论文) 7. Pan, X., N. Zhang, X. Wei, Y. Jiang, R. Chen, Q. Li, R. Liang, L. Zhang, L. Ma, and C. Xia*. 2019. Illumination of PRRSV Cytotoxic T Lymphocyte Epitopes by the Three-Dimensional Structure and Peptidome of Swine Lymphocyte Antigen Class I (SLA-I). Front. Immunol .10: 2995. 8. Liang, R., Y. Sun, Y. Liu, J. Wang, Y. Wu, Z. Li, L. Ma, N. Zhang, L. Zhang, X. Wei, Z. Qu, N. Zhang*, and C. Xia*. 2018. Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides. Journal of Virology 92. 9. Wu, Y., J. Wang, S. Fan, R. Chen, Y. Liu, J. Zhang, H. Yuan, R. Liang, N. Zhang*, and C. Xia*. 2017. Structural Definition of Duck Major Histocompatibility Complex Class I Molecules That Might Explain Efficient Cytotoxic T Lymphocyte Immunity to Influenza A Virus. Journal of Virology 91. 10. Chen, Z., N. Zhang, J. Qi, R. Chen, J. M. Dijkstra, X. Li, Z. Wang, J. Wang, Y. Wu, and C. Xia*. 2017. The Structure of the MHC Class I Molecule of Bony Fishes Provides Insights into the Conserved Nature of the Antigen-Presenting System. Journal of Immunology 199: 3668-3678. 11. Yao, S., J. Liu, J. Qi, R. Chen, N. Zhang, Y. Liu, J. Wang, Y. Wu, G. F. Gao, and C. Xia*. 2016. Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles. Journal of Immunology 196: 1943-1954. 12. Fan, S., Y. Wu, S. Wang, Z. Wang, B. Jiang, Y. Liu, R. Liang, W. Zhou, N. Zhang, and C. Xia*. 2016. Structural and Biochemical Analyses of Swine Major Histocompatibility Complex Class I Complexes and Prediction of the Epitope Map of Important Influenza A Virus Strains. Journal of Virology 90: 6625-6641. 13. Chen, R., J. Qi, H. Yuan, Y. Wu, W. Hu, and C. Xia*. 2015. Crystal structures for short-chain pentraxin from zebrafish demonstrate a cyclic trimer with new recognition and effector faces. Journal of Structural Biology 189: 259-268. 14. Liu, Y., X. Li, J. Qi, N. Zhang, and C. Xia*. 2016. The structural basis of chicken, swine and bovine CD8alphaalpha dimers provides insight into the co-evolution with MHC I in endotherm species. Scientific Reports 6: 24788. |