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朊病毒分子机制的研究

发布日期:2017-06-19访问次数: 信息来源:动物医学院字号:[ ]


报告人:Prof.Jiyan Ma 

工作单位:Center for Neurodegenerative Sciences

Laboratory of Prion Mechanisms in Neurodegeneration

Van Andel Research Institute, Grand Rapids, Michigan, USA

时间:2017年6月21日(周三),10:00-11:30 

地点:中国农业大学实验动物研究所308室,国家动物海绵状脑病实验室

联系人:杨利峰  010-62732987

Selected publications:

1. Wang X, McGovern G, Zhang Y, Wang F, Zha L, Jeffrey M, Ma J. (2015) Intraperitoneal infection of wild-type mice with synthetically generated mammalian prion PLoS Pathog 2015 Jul 2;11(7):e1004958. 

2.Yu G, Liu H, Zhou W, Zhu X, Yu C, Wang N, Zhang Y, Ma J, Zhao Y, Xu Y, Liao L, Ji H, Yuan C,Ma J. (2015) In vivo protein targets for increased quinoprotein adduct formation in aged substantianigra . Exp Neurol , 2015 Sep;271:13-24. 

3. Ma J. and Wang F. (2014) Prion disease and the “Protein-only hypothesis”. In Sarah Perrett (Ed)Amyloid in Health & Disease, Essays in Biochemistry, 56:181-91.

4. Zhang Z, Zhang Y, Wang F, Wang X, Xu Y, Yang H, Yu G, Yuan C, Ma J. (2013) De novogeneration of infectious prions with bacterially expressed recombinant prion protein. FASEB J.27(12):4768-75.

5. Ma J. (2012) PrP Conversion and Lipids. In W.-Q. Zou and P. Gambetti (Eds) Prions and Diseases:Volume 1, Physiology and Pathophysiology (107-119).

6. Ma J. (2012) The role of Cofactors in Prion Propagation and Infectivity PLoS Pathog 8(4): e1002589.doi:10.1371/journal.ppat.1002589.

7.Wang F, Zhang Z, Wang X, Li J, Zha L, Yuan C, Weissmann C, Ma J. (2012) Genetic informationalRNA is not required for recombinant prion infectivity J. Virol. 86(3): 1874-1876.

8.Wang N, Wang Y, Yu G, Yuan C, Ma J. (2011) Quinoprotein adducts accumulate in the substantia nigra of aged rats and correlate with dopamine-induced toxicity in SH-SY5Y cells . Neurochem Res.36(11):2169-2175.

9.Wang, F., Wang, X., Yuan, C., Ma, J. (2010) Generating a Prion with Bacterially Expressed,Recombinant Prion Protein , Science, 327:1132-1135.

 






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