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Defining Host Resistance and Pathogenesis in Toxoplasma gondii

发布日期:2017-10-18访问次数: 信息来源:动物医学院字号:[ ]


报告人: Laurence David Sibley 美国华盛顿大学 教授、美国科学院院士

报告时间:20171024日下午4

报告地点:动医动科大楼401会议室

联系人:刘晶

  话:62732622

 

专家简介:

弓形虫病专家,在Nature, Science, Cell发表了10余篇研究论文。截止至20175月共发表了231SCI研究论文,被引用17990次。

http://www.sibleylab.wustl.edu/

U.S. National Academy of Science member, Alan A. and Edith L. Wolff Distinguished Professor in the department of Molecular Microbiology, Washington University School of Medicine. The main focus of Prof. Sibley's research is using Toxplasma gondii as a model to study the unique adaptations for parasitism in apicomplexan parasites, as well as the cross-talk between hosts and parasites that determines the outcome of the infections. Prof. Sibley has published more than 230 peer reviewed papers in top scientific journals, such as Science, Nature, Cell, Nat Communications etc. Over the last a few years, Prof. Sibley has won numerous awards, including Burroughs Wellcome Fund Scholar Award in Molecular Parasitology and Alice and C.C. Wang Award In Parasitology. He is on the advisory boards of quite a few top research institutes, such as Wellcome Trust and Institut Pasteur. Meanwhile, he is serving as editors for a number of journals that include Science, PLoS Pathogens, mBio and Annual Review of Microbiology.

 

Selected Publications

1. Alaganan A, Fentress SJ, Tang K, Wang Q, Sibley LD: Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1126-31. PMID: 24390541

2. Skillman KM, Ma C, Fremont DH, Cooper JA, Sept D, Sibley LD: The unusual dynamics of Toxoplasma actin result from isodesmic polymerization. Nat. Comm. 2013, 4:2285. PMID: 23921463.

3. Sibley LD: The roles of intramembrane proteases in protozoan parasites. BBA Biomembranes 2013, 1828; 2908-2915. PMID: 24099008.

4. Selleck EM, Fentress SJ, Beatty WL, Degrandi D, Pfeffer K, Virgin HW, MackMicking JD, and Sibley LD: Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii PloS. P., 2013 e1003320. PMID: 23633952.

5. Lourido S, Zhang C, Lopez M, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, and LD Sibley. Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. J. Med. Chem. 2013 56:3068-77. PMID: 23470217.

6. Lourido S, Jeschke GR, Turk BE, and LD Sibley: Exploiting the unique ATP-binding pocket of Toxoplasma calcium-dependent protein kinase 1 to identify its substrates. ACS Chem. Biol. 2013,8:1155-1162. PMID: 23530747

7. Shen B, and Sibley LD: The moving junction, a key portal to host cell invasion by apicomplexan parasites. Curr. Opin. Micro. 2012, 15, 449-

455. PMID: 22445360.

8. Hunter C, Sibley LD: Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat, Rev Microb. 2012, 10(11):766-78. PMID:

23070557.

9. Behnke MS, Fentress SJ, Mashayekhi M, Virgin HW, Sibley LD: The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii

by regulating the active kinase ROP18. Plos P., 2012, 8(11): e1002992. PMID: 23144612.

10. Lourido S, Tang K, Sibley LD: Distinct signaling pathways control Toxoplasma egress and host-cell invasion. EMBOJ, 2012 31, 4514-4534.

PMID: 23149386.

11. Su CL, Khan A, Zhou P, Majumdar D, Ajzenberg D, Dardé ML, Zhu XQ, Ajioka JW, Rosenthal B, Dubey JP Sibley LD: Globally diverse

Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages. Proc. Natl. Acad. Sci.(USA), 2012, 109:5844-9. PMID: 22431627.

12. Sibley LD: Invasion and intracellular survival by protozoan parasites. Immunol. Rev. 2011, 240, 72-91. PMID: 21349087.

13. Khan A, Miller N, Roos DS, Dubey JP, Ajzenberg D, Darde ML, Ajioka JW, Rosenthal B, Sibley LD: A monomorphic haplotype of chromosome Ia is associated with widespread success of clonal and nonclonal populations of Toxoplasma gondii. mBio, 2011, 2:e00228-11. PMID:22068979.

14. Skillman KM, Diraviyam K, Khan A, Tang K, Sept D, Sibley LD: Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites. PLoS Pathogens, 2011, 7(1): e1002280. PMID: 21998582.

15. Mashayekhi M, Sandau MM, Dunay IR, Fickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM: CD8 alpha dendritic cells are the critical source of IL-12 controlling acute infection by Toxoplasma gondii tachyzoites. Immunity, 2011, 35, 249-259. PMID:21867928.

16. Mehta S, Sibley LD: Actin Depolymerizing Factor controls actin turnover and gliding motility in Toxoplasma gondii. Molec. Biol. Cell, 2011, 22, 1290-1299. PMID: 21346192.

17. Behnke MS, Khan A, Wootton JC, Dubey JP, Tang K, Sibley LD: Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9631-6. PMID: 21586633





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