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>> 科学研究 >> 师资队伍 >> 基础兽医系 >> 副教授
姓名:张蕊 性别: 职务:
所在系:基础兽医学系 职称:副教授 导师类别:
政治面貌:中共党员 出生年月:1983.05 学位:博士
电子邮件:zhangrui_2046@163.com 办公电话:010-62733484

教育背景:

2003~2007  西南大学动物医学专业, 获兽医学学士学位

2007~2010  中国农业大学预防兽医学专业,获兽医学硕士学位

2010~2014  加拿大University of Saskatchewan兽医微生物及肿瘤学专业,获博士学位

教学工作经历:

2015~至今   中国农业大学基础兽医系,副教授

主讲课程:本科《动物细胞生物学》《兽医生物技术》,研究生《细胞生物学实验技术》 

研究领域:

病毒与宿主天然免疫系统的相互作用研究

肿瘤发生和发展的信号转导机制及调控途径研究 

科研项目:

主持和参与国家自然科学基金项目3项,北京市自然科学基金项目1项,中央高校基本科研业务费青年教师创新项目1项等。

5年代表性文章(*通讯作者):

1.*Zhang R, Cui D, Xue T, Lang Y, Li, Sun H, Kuang Y, Li G and *Tang J. (2019). HLA-B-associated transcript 3 (Bat3) stabilizes and activates p53 in a HAUSP-dependent manner. J Mol Cell Biol. 

2.Zhang R, Wang W, Wang J, Tang J, Wang M, *Kuang Y. (2019). Antitumor Activity of Muricatacin Isomers and Its Derivatives in Human Colorectal Carcinoma Cell HCT116. Anticancer Agents Med Chem. 

3.Qin C, Zhang R, Lang Y, Shao A, Xu A, Feng W, Han J, Wang M, He W, Yu C, Tang J. (2019). Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3. PLoS Pathog. 15(1):e1007559.

4.Zhang R, Xu A, Qin C, Zhang Q, Chen S, Lang Y, Wang M, Li C, Feng W, Zhang R, Jiang Z, *Tang J. (2017). Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response. J Virol. 91: e01148-17.

5.Wang Z, Hou X, Wang Y, Xu A, Cao W, Liao M, *Zhang R, *Tang J. (2017). Ubiquitination of non-lysine residues in the retroviral integrase. Biochem Biophys Res Commun. 494:57-62.

6.Zhang R, Thamm DH, Misra V. (2015). The effect of Zhangfei/CREBZF on cell growth, differentiation, apoptosis, migration, and the UPR in several canine osteosarcoma cell lines. BMC Vet Res 10.1186/s12917-015-015-0331-y.

7.Zheng J, Lang Y, Zhang Q, Cui D, Sun H, Jiang J, Jiang L, Chen Z, Zhang R, Gao Y, Tian W, Wu W, Tang J, Chen Z. Structure of human MDM2 complexedwith RPL11 reveals the molecular basis of p53 activation. Gene & Development, 2015, 29(14):1524-34.

8.Zhang R, Misra V. (2014). Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53. Cell cycle 13: 279-292.

9.Ying Z, Zhang R, Verge VM, Misra V. (2015). Cloning and characterization of rat Luman/CREB3, a transcription factor highly expressed in nervous system tissue. J Mol Neurosci. 55:347-354.

10.Zhang R, Rapin N, Ying Z, Shklanka E, Bodnarchuk TW, Verge VMK, Misra V. (2013). Zhangfei/CREB-ZF - A Potential Regulator of the Unfolded protein Response. PLoS One 8: e77256.  

 

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